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For voters for whom innocent life is sacred, Guiliani's nomination would mean that both major political parties have been captured by the Culture of Death. If nominated, Giuliani must be defeated, if only to remind the Republican Party that the sanctity of life remains an important issue for at least part of its base. If he's nominated by the Republicans, I'll vote for the democrat.
Of course, Guiliani is also unacceptable to many Republican/conservative voters because of his positions on guns, homosexual "rights" and illegal immigration. As mayor, he forbade the NY police from cooperating with the old INS. He regularly pandered to ethnic groups, winking and nodding at the ruthless terrorists of the IRA.