The M1 Will reach out and "touch" someone. The Mini 14 isn't named the poor mans assault rifle for nothing.
Ammo is also a key to weapons choosing. the .223 is readily available and cheaper than the 30-06. Both are excellent killing machines.
Have you checked CMP?
I, too, use an M1 Garand for long distance and a 1911-A1 [45 cal. pistol] for the close stuff. I have used both "in the heat of battle" and for target. These two weapons have great hitting power, are very accurate, and are very reliable.
2 Springfields
2 H&R's
1 Winchester
1 International Harvester
All of them except for my first Springfield were purchased directly from CMP. I also have a '03A3 (Remington) that I got from them. CMP is also a pretty good source for ammo and accessories. I have the good luck of living in Pittsburgh which is only about 200 miles from the CMP store at Camp Perry.
If you are shooting someone at a distance, then it no longer is defensive. A rifle is inappropriate for defense in the situation you envisage. Get a handgun and/or a shotgun.
Who's ready to file a Sherman Act case and take on the CMP as an anti-competitive monopoly?