"It involves Mark Twain, The Players Club (no, not that Players Club), President Grant, The Sultan of the Ottoman Empire, Queen Victoria, the death of three presidents, Billy the Kid, the Civil War, Andersonville, The Pullman Company, Nicola Tesla, and much more, including the heart of the "Gilded Age."
I've always wanted to write a novel with these folks (and a few others) wandering in and out of my central character's life. It would span from about 1840 to 1940. Perhaps the most incredible and dangerous period in human history."
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Just try to keep it historically plausible. I saw "The League of Extraordinary Gentlemen" blech.
The point is that the people, and a good many other equally well known names and events, really did come into contact. The trick would be coming up with a plausible central character.
It might be easiest to use one of the real individuals. Most likely the younger Lincoln, though he's not 100% sympathetic.