Hopefully that won't happen very often. That was one of the arguments used against the 747 when it came out. One of the rebuttals is that with fewer planes flying around, it is easier for air traffic control to prevent midair collisions.
If it does as well as recent aircraft models, that may never happen. The 777 which has been in service since June of 1995 has never had a fatal incident. Neither have the A330, A340, or Next Generation 737s.
good point.