How could this be observed? More importantly, how could this be falsified?
There's a moving account in Sacks' Man who mistook his wife for a hat of a (iirc) stroke victim who became blind and had no memory of what seeing was.
My point to js1138 is the the results of such clinical tests would look the same whether one views the mind as an epiphenomenon of the physical brain or whether the physical brain is the mechanism of mind (like a transmitter/receiver). In order to make a deduction in the scientific method, there must be several ways to falsify a theory.