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Posted on 08/14/2026 9:44:19 PM PDT by Red Badger
Calls to poison centers involving liver injuries caused by medications, supplements, alcohol and other substances jumped nearly 400% between 2000 and 2024, according to a new study from UVA Health published in Clinical Gastroenterology and Hepatology.
Researchers led by UVA's Christopher P. Holstege, MD, looked at liver damage caused by "xenobiotics," foreign substances not naturally found in the human body. This category includes drugs, food additives, alcohol and environmental pollutants.
More than 80% of the liver injuries required inpatient care, with the majority of cases stemming from medications. Acetaminophen was the most frequently implicated substance.
"Xenobiotic-induced liver injuries reported to U.S. poison centers have steadily increased," said Holstege, director of UVA Health's Blue Ridge Poison Center. "The public should be aware of potential liver injury with various substances that are readily available to consumers."
Liver injury causes
Holstege and his colleagues identified a total of 220,160 cases of xenobiotic liver injury over the 24 years reviewed. Population-adjusted exposure rates skyrocketed from 10.9 per million people to 52.9 per million people.
The researchers found that exposures from acetaminophen-containing drugs decreased significantly—by 60%–85%—after the U.S. Food and Drug Administration imposed a cap on the amount of acetaminophen allowed in combination prescription products. By contrast, potentially harmful exposures to acetaminophen by itself increased steadily over the 24-year period, indicating that regulatory action successfully reduced liver damage from combination products, while acetaminophen alone remains a leading contributor to liver injuries reported to poison centers.
Females had higher rates of acetaminophen-associated liver injury than males, and suspected suicide was the most common reason for exposure in both sexes, the study found.
"Liver injuries reported to poison centers have increased substantially over the past 25 years, with acetaminophen emerging as a growing contributor," Holstege said. "Our study findings highlight the important role poison centers play in toxico-surveillance."
Alcohol was a distant second among the top causes of liver injuries. This was seen more frequently in men than women, but injuries increased in both sexes during the COVID-19 pandemic.
The researchers also identified increases in liver injuries caused by stimulants and street drugs, herbal and dietary supplements and environmental toxins, but these were far less common than injuries caused by acetaminophen and alcohol.
"Medications should always be taken as directed by clinicians and according to pharmaceutical label instructions," Holstege said. "Care must also be taken when consuming emerging substances that are unregulated. More studies are warranted to determine if specific populations are more at risk of liver injury."
Publication details
Eleanor Blair Towers et al, Xenobiotic-Induced Liver Injury in the United States: A 25-Year Retrospective Analysis of National Poison Data System, Clinical Gastroenterology and Hepatology (2026).
DOI: 10.1016/j.cgh.2026.07.032 linkinghub.elsevier.com/retrie … ii/S1542356526005732
Journal information: Clinical Gastroenterology and Hepatology
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Tylenol killed Nicolette Larson.
I tried finding their results on supplements. The article is paywalled. Claude found this:
Every article I found (UVA Health's own press release, News-Medical, NaturalNews, Gizmodo, MedicalXpress) says the same thing in different words — supplements were a rising but "relatively small" contributor compared to acetaminophen (the dominant cause, ~33-45% of cases) and alcohol (second place), and none of them list which supplements specifically.That's likely because the paper itself, going by how it's being covered, focuses its detailed breakdown on acetaminophen and alcohol trends, with supplements/herbals mentioned as a category-level rising trend rather than a named-substance analysis — the abstract alone (which is all that's freely visible pre-paywall) probably doesn't itemize them either.
If you want supplement-specific names, the article that actually names culprits comes from a different but related dataset — the Drug-Induced Liver Injury Network (DILIN), not the National Poison Data System. A 2024 JAMA Network Open study on DILIN found supplement-related liver injury cases nearly tripled from 2004-2014, and named the most common offenders as: turmeric, kratom, green tea extract, ashwagandha, garcinia cambogia (weight loss), red yeast rice (cholesterol), and black cohosh (menopause).
"Green tea extract" in this context refers to a concentrated supplement, not the beverage (ceremonial matcha or otherwise). It's typically made by processing green tea leaves (Camellia sinensis, the same plant matcha comes from) into a concentrated powder or pill form, standardized for a compound called EGCG (epigallocatechin gallate) — often at doses far higher than you'd get from drinking tea, sometimes equivalent to many cups' worth concentrated into one capsule.
That concentration is exactly why it's flagged for liver risk: the isolated, high-dose extract form has been linked to liver injury in case reports, while just drinking brewed green tea (including matcha) hasn't shown that same risk pattern. So it's less "the tea itself is dangerous" and more "concentrating and isolating the compound into pill form changes the risk profile."
But not real fast, despite the fact that she consumed massive doses of it. Way beyond the daily dose limits clearly marked on the packaging.
That’s really a bad way to die.
I remember hearing (on an NPR program, back in the 1980s) that acetaminophen has the narrowest margin of "therapeutic dose" to "toxic dose" of any consumer OTC (non-prescription) medicine.
That same story also said that J&J had paid for hundreds of liver transplants on the down-low, with NDAs demanded all around, to keep the dangers of Tylenol out of the public eye.
I’m stage four kidney disease...”Tylenol” is the only thing that my kidney Dr. tells me I can take.
If I have to take Tylenol, I also take NAC. Ck it out.
And lots and lots of Valium.
Be careful of multi-drug products that also contain Acetaminophen. If you take Tylenol and some cold medication and something else you can quickly OD on Acetaminophen without knowing it. Generally I try to take single ingredient medications so I don’t get a nasty surprise.
Why say 400% instead of saying 4 times? Because 400% is a much, much, bigger number!
Yes, im told to take Tylenol too because of ckd.
Its gonna take a Lotta love.
After the 1982 Chicago Tylenol poisonings, it was known as “Tylenide”. Take two and instruct somebody else to call 911 for you in the morning.
“Tylenol is the most common brand of medication with active ingredient acetaminophen. I use it occasionally due to Advil (ibuprofen), a nonsteroidal anti-inflammatory (NSAID) drug problems with blood thinners.”
Ditto. Acetaminophen is the only thing I can use, being on Eliquis. Thankfully, I only take one about twice a year.
I don’t get it.. Why is my doc telling me to stop using Aleve, that I should take Tylenol instead. Is he trying to kill me or what.??
“Females had higher rates of acetaminophen-associated liver injury than males“
Because of all the pregnant liberal TDS infected women chugging Tylenol to prove Trump is wrong about something. Hateful harpies.
“Females had higher rates of acetaminophen-associated liver injury than males“
Because of all the pregnant liberal TDS infected women chugging Tylenol to prove Trump is wrong about something. Hateful harpies.
I’m convinced he is talking about vaccines so that liberals will take them,
I’m on a blood thinner and I’m only supposed to take Tylenol for pain - even though low-dose opioids work better and do less damage to your organs. But it takes about 24 325 mg Tylenols to reach the lower toxicity threshold in a 24 hour period. Frankly, since I have had zero bleeding problems over a 20 month period on blood thinners, I’m more apt to take a one or two pill dose of Aleve before turning to Tylenol - but only once in any day and no more often that once a week.
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