Vance as SOS...he needs more foreign affairs work. IMHO
He’s got a lot of time. ~3 years.
I’m liking Rubio at the top. His calm demeanor is appealing.
He can, and is, getting that as VP.
If you are suggesting Rubio as the presidential candidate, Vance can still remain as the VP candidate on the ticket.
Though another option is Vance just holds over the Trump cabinet, including Rubio as SOS. Cabinet secretaries don’t have “terms” - once confirmed, they can stay until they resign or are fired by the President. They don’t have to be confirmed again - so that would help avoid confirmation fights to start a Vance administration.