NAD⁺ restores memory in Alzheimer's disease models by correcting RNA errors

Medical Xpress / University of Oslo / Science Advances ^ | Nov. 10, 2025 | Ruixue Ai et al

[ConservativeMind]

Taking some of either of the following supplements appears to give this benefit. From the write up:

“Preliminary studies have shown that supplementation with NAD⁺ precursors, such as nicotinamide riboside (NR) or nicotinamide mononucleotide (NMN), can offer therapeutic benefits in AD animal models and early clinical trials.”

I take a small amount of nicotinamide riboside, nearly daily. I get it in a powder form and just put it in water.

It does suck in moisture, in that form, however, so I now keep it in the refrigerator.

[ConservativeMind]

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[Cletus.D.Yokel]

Amount you take?

[sauropod]

Bkmk

[BipolarBob]

Is this available OTC?

[ConservativeMind]

I take between 1/16 and 1/32 of a teaspoon of the following:

Renue By Science Nicotinamide Riboside | 1000mg Nicotinamide Powder - High Strength NR NAD Powder Sublingual Citrus Burst Flavor

https://www.amazon.com/gp/aw/d/B0CVX411WW?psc=1

[Cletus.D.Yokel]

Thank you.
ALZ runs in my family.

[SubMareener]

You have to be very careful with NAD+ directly. Especially when they come in Strawberry flavored chewable pills. Messes with your pancreas, blood sugar and heart rhythm. Stick with the precursors and let your body decide how much NAD+ to make.

[crosdaddy]

Yes

[ConservativeMind]

I am with you and taking NAD+ directly is something we don’t do.

[LastDayz]

Read an article other day that DMSO is the cats meow for this type of illness.

[LastDayz]

Found it...

https://www.midwesterndoctor.com/p/the-great-alzheimers-scam-and-the

[jimwatx]

Taking 1000mg of nicotinamide presents some risks. I use to take that amount because it relaxes me but it can down regulate sirtuins and screw up your body’s methylation.

Risks and Benefits of Nicotinamide (NAM), a NAD+ Booster
https://www.youtube.com/watch?v=WMWG_W7vGI0

[Cats1]

bookmark

[Newbomb Turk]

Do you take NMN or NR and let yor body cover it to NAD ?

[Revel]

When looking up this stuff then I discovered this:

“some newer e-cigarettes and smokeless tobacco products are being marketed with nicotinamide as a substitute for nicotine, sometimes in combination with other substances like 6-methyl nicotine.”

[grobdriver]

Bookmark

[SubMareener]

It has taken me six months to recover and get my A1C back in normal range.

[Captain Peter Blood]

My partner had some memory issues and such. I gave her neurologist and article about high does of Vitamin D3 that showed it might help. He said that was a good idea and to go on and try it. We had some good results from it and she actually got better.

I had her on like 5000 to 10,000 units a day for along time. At a check up her D test was 114 and normal is 80 so I cut her back, but still kept her level at close to 80. She never got sick and when Covid came we were both on the High Vitamin D3 level and we didn’t get Covid either. I keep my level at close to 70.

[ConservativeMind]

That is why I take a tenth or so of that amount.