Posted on 12/30/2023 7:40:23 PM PST by ConservativeMind
For young children with febrile urinary tract infection (fUTI), a five-day amoxicillin-clavulanate course is noninferior to a 10-day course for recurrence of UTI within 30 days after completion of therapy, according to a study published.
Giovanni Montini, M.D. and colleagues conducted a multicenter, randomized, controlled trial involving children aged 3 months to 5 years with a noncomplicated fUTI to assess the noninferiority (5 percent threshold) of a five- versus 10-day antibiotic course. A total of 142 children were randomly assigned to receive amoxicillin-clavulanate 50 + 7.12 mg/kg/day orally in three divided doses for five or 10 days (72 and 70 children, respectively). The recurrence of a UTI within 30 days after completion of therapy was examined as the primary end point.
The researchers found that the recurrence rate within 30 days of the end of therapy was 2.8 and 14.3 percent, respectively, in the short and standard groups (difference, −11.51 percent). The recurrence rate of fUTI within 30 days from the end of therapy was 1.4 and 5.7 percent in the short and standard groups, respectively.
"In this study, a five-day treatment with oral amoxicillin-clavulanic acid of an acute episode of fUTI was not inferior to a 10-day course, in terms of clinical cure rates, recurrence of infection within 30 days from the end of therapy, adverse events, and development of antibiotic resistance," the authors write.
(Excerpt) Read more at medicalxpress.com ...
The standard regimen had a 3.5X higher infection relapse rate at 30 days and 2.5X at the 60 day mark.
“First, do no harm.”
2.9X at the 60 day mark, it appears.
Goods news from now on five days and freeze the rest
Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.