Inflammation accelerates aging of the hematopoietic system (Blood stem cell dysfunction)

Medical Xpress / German Cancer Research Center / Cell Stem Cell ^ | August 4, 2022 | Ruzhica Bogeska et al

[ConservativeMind]

In mice, inflammation in early to mid-life leads to a permanent decline in functional blood stem cells. The ability of the blood stem cells to regenerate was suppressed for at least one year after challenge with inflammation, suggesting that infection and inflammation may act as a prominent driver of age-associated functional decline in tissues.

Blood stem cells in the bone marrow provide a lifelong replenishment of the different cell types making up the blood system. In addition, they are also of capable of making new stem cells. In older people, diseases of the hematopoietic system often occur, such as anemia or certain forms of blood cancer. Such diseases are thought to be caused by an age-associated decline in stem cell self-renewal.

According to experts, the cause of this age-related loss of function of the hematopoietic system is a chronic low-grade inflammatory condition called inflammaging, that only develops in later life and impairs the function blood stem cells. "However, the question that we wanted to answer was whether inflammation and infections in early life can permanently damage blood stem cells and thus promote aging of the blood system," says Mick Milsom. "We came to the surprising conclusion that we never see any evidence of stem cell recovery, suggesting that this process is long-lasting or perhaps even irreversible."

The researchers subsequently identified the cause of the dysfunctional hematopoiesis: Blood stem cells failed to self-renew as they were forced to divide in response to the inflammatory stimuli. The long-term consequence is that the hematopoietic system becomes exhausted. "This observation in mice contradicts common doctrine: we had previously believed that, after inflammatory challenge, blood stem cells revert into a so-called dormant state that preserves their capacity for self-renewal," says Milsom.

[ConservativeMind]

We need to reduce the negative inflammatory damage to our bodies, throughout our lives.

The dormant state the stem cells revert to is likely a state called “senescent.” This means the cells are still hanging around, but not ever capable of doing anything.

It was believed these cells needed to be removed, but, more recently, it has been determined senescent cells can be brought back to action, by at least two methods, by providing intrinsic antioxidants they used to produce, through GlyNAC supplementation, or by regenerating the cells’ mitochondria, through Urolithin-A.

Both of these have been described in prior threads, and the health benefits are many.

[ConservativeMind]

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[Skywise]

Actually that seems patently obvious that inflammation accelerates stem cell activation - ergo - promotes wearing out of the stem cells faster.

But just suppressing inflammation isn’t a benefit either - check out studies of NSAID usage by athletes that resulted in the body hindering muscle production because the same inflammatic process is also used to rebuild the body to make it stronger.

[Caipirabob]

Coincidentally spike proteins are exceedingly inflammatory.