P365 is an excellent gun. I’d take it over a 38.
Second that - I carry the P365XL and hardly notice it.
I sure like it.
I don’t know about a lot about Sigs, but a double action semi-auto like this would work; no safety!!!!. Glocks, like the slimline Glocks would do. They go bang every time you pull the trigger. Less expensive than a Sig, but if you have the money a Sig is a bit better feeling than the Glock. Don’t know about automobile safes.
460 S&W. I didn’t read what you actually posted, but you can’t go wrong.