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To those who still pretend that the 'Covid Vaccine' is 'safe and effective', where's your evidence? Please refute Steve Kirch's report and provide 10 years of data.
10/18/2021 | vanity

Posted on 10/18/2021 5:27:19 PM PDT by ransomnote

ransomnote: Below, I posted my response to one of countless posts to me stating that I post Covid content without merit in order to push 'an agenda'. The name of the freeper this time is irrelevant because other have said the same thing. 

Freeper: This is a tour d’force of maybes, ifs and allegations that uses one theoretical allegation to build on the next.

You and others on FR working to keep the Plandemic alive rely on inuendo and allegations. To support the 'narrative', your content supports an entire fabric of lies.

* You imply 'Covid' is far more deadly than it is. Even the CDC admitted in May that 94% of "Covid" deaths are persons with an average of 4 co-morbidities (hint: they died of other things). It's not just the US that has ridiculously inflated 'Covid' death tolls.

Lisbon Court Rules Only 0.9% Of ‘Verified Cases’ Died Of COVID, Numbering 152, Not 17,000 As Claimed
greatgameindia.com ^ 

* You insist there are no treatments and so you push the vax. Ivermectin, HCQ work around the world, but you say they don't.

Dr Robert Malone @RWMaloneMD | Peru-> last half of 2020. Mortality dropped 14 fold over 3 months with Ivermectin, rose 13 fold when Ivermectin removed

C19Protocols – Reducing Risk of COVID-19 Infection and Severity

A Guide to Home-Based COVID Treatment
aapsonline.org ^ | December 11, 2020 | Jane M. Orient M.D., & Elizabeth Lee Vliet, M.D.

* You pretend the 'Covid' tests are valid.

FDA document admits “covid” PCR test was developed without isolated covid samples for test calibration, effectively admitting it’s testing something else
fos-sa.org ^ | August 2, 2021 | Naomi Wolf

* You pretend the Delta variant is behind the 'surge' and is reason to get the vax.

Dnice4Jesus @DeniceMarin emailed the CDC to ask them how they are verifying what variant is dominant. This was their answer. Thoughts?
Twitter ^ | 7/29/2021 | Dnice4Jesus @DeniceMarin

* Overall, your firm support for the 'narrative' indicates your belief that Fauci/NIH/CDC are telling the truth.

"Conspiracy theorist" Robert Kennedy Jr. explains relationship between world’s most powerful doctor Bill Gates and Dr. Fauci [2 minute Video]
twitter.com ^ | April 19, 2021 | Camus @husserl80

Bill Gates, George Soros and others are driving the CDC's medical Tyranny with Private Donations to CDC Foundation. We have to reject the CDC to free ourselves.
5/3/2021 | vanity

You pretend the entire basis for China Biden's Plandemic is legit while posting as a conservative on FR. 

You are never skeptical about the 'Plandemic Narrative' no matter how many reports surface around the world contradicting it; you have no doubts or questions for the CDC. When real people come forward, put their reputations and credentials on the line, and pierce the 'Plandemic Narrative', you say they're fake and it costs you and your annonymity NOTHING.

You ridicule real doctors with impressive accomplishments who are saving lives with their safe, effective treatment protocols and education. It's war and you just happen to prefer ALL of the key talking points of those working to destroy us.

Mind you there is no meaningful data in your claim or any claim.

ANY CLAIM. Just a blanket denial. Fauci supporters always start by saying that anything people write against the Plandemic has no meaning, isn't real etc.

Plandemic Indoctrination [watch movie free, free to download] Includes notes on 7 minute sample excerpt of the movie: Clip 03 Turning CoronaVirus from a pathogen to a profit
freedomplatform.tv ^ | August 18, 2020 | Dr. David E Martin

The CDC and NIH use the same tactic. Pretend there is no evidence and then say things like, "We're not aware of any reason why pregnant women shouldn't get the 'vaccine....' That will be their excuse - they weren't aware.

As the public wakes up, the Faucists and CDC supporters are preying on a smaller and smaller number of people who haven't woken up.

Karl Denninger runs the numbers on Market-ticker.com. Please write him and explain how his statistics which show 1.2 million people of working age are missing from the job market are wrong, because he doesn't want it to be true. He keeps asking someone to explain it to him; he doesn't want to be right. But be careful; Karl knows what he's talking about, has been crunching these numbers for  years, and he's not impressed with fake and/or anonymous credentials, medical degrees etc. 

There are unsubstantiated allegations.

Americans are doing a good job of pinning our domestic enemies to the floor with facts. The CDC has simply stated over and over 'those facts don't exist', just like the corrupt traitors in Congress and the MSM keep stating there is no evidence of 2020 election theft.

The CDC, Pharma etc. don't respond to public inquiry or answer questions. They flat 'overrule' the public while behaving as if they are our overlords; they shall determine who 'gets' to claim facts, and who 'gets' to be threatened, censored silenced and smeared.

The weaponized medical establishment fell into a stunned silence and was unable to refute the information presented by Steve Kirsch, even the part where he offers 1 million dollars for NIH/CDC/FAUCI to debate him on the facts. Our enemies did what you do - they ignored him.

Comment to ACIP meeting of August 30, 2021 submitted by Steve Kirsch (with 20 experts including Dr Malone, Dr. Vanden Bossche, Dr. McCullough, Dr. Pierre Kory, Dr. Fareed
skirsch.com ^ | August 30, 2021 | Steve Kirsch

I'm amazed you and others who push (shove) the 'vaccine' are not concerned with all the CDC's 'unsubstantiated allegations'. Why aren't you skeptical of their edicts and pronouncements?

You and your buddies in the CDC are thoroughly unconcered that the Covid vaccines were tested briefly and have zero interest in long term effects. A 'normal' year might have 300 deaths post vaccination, but since Covid, were' way up in the thousands and you're yelling "SITUATION NORMAL!" You never ask the CDC or NIH or Fauci for evidence to prove anything- you just PUSH and SHOVE THE VAX.  

I am my colleagues have seen no vaccine injuries hospitalized.

You and other fake anonymous doctor 'colleagues' pretend to work in magical hospitals with patient populations which magically conform to the 'Plandemic Narrative'. The rest of America, and the rest of the world is living in reality where the vaccinated are being infected, spreading the infection, being hospitalized and dying in increasing rates. You will pretend this information does not exist.

Infection Rate in Vaccinated People in Their 40s Now More Than DOUBLE the Rate in Unvaccinated, PHE Data Shows, as Vaccine Effectiveness Hits Minus-109%
Daily Sceptic ^ | 15 October 2021

More deaths from vaccinations than from Covid-19 in Taiwan
FreeWestMedia ^ | October 17, 2021 | Staff

Latest UKHSA report shows Vaccinated accounted for 80% of Covid-19 Deaths and 60% of Hospitalisations in the last 4 weeks
theexpose.uk ^ | 10/16/2021 | The Expose

Real doctors put their profession and reputation on the line to save people, and you and other anonymous, fake doctors predictably attack him/her. You've never said anything approving of those who are taking  a beating, unduring threats and suppression, and censorship. Why not at least refute their evidence, instead of ignoring it? Because you can't.

THE VACCINE DEATH REPORT Version 1.0 [Outstanding, one-of-a-kind collection of critical medical, social and survival aspects of our enemies' tactics and goals] PDF at link
stopworldcontrol.com ^ | 9/26/2021 | John Sorenson and Dr. Vladimir Zelenko

Dr. Ryan Cole: weakening our immune system, e.g., since Jan 1, the lab has seen a 20 times increase of endometrial cancer (Transcript and link to two minute video)
Twitter ^ | Aug 25, 2021 | Dr. Ryan Cole via @ToTheLifeboats

There is no massive uptick in unexplained deaths. If the roughly 355 million doses of vaccination used were producing even a fraction of that which you claim it would be overwhelmingly evident. Where are the bodies?

There is a massive uptick in unexplained deaths. And sadly, many have injuries - they are flooding the hospitals now and they are falsely classified as 'unvaccinated'. Obitituaries now simply say "sudden illness".

Fox News Whistleblower: My Boss Told Me ‘Do Not Report Deaths After Vaccination’ [includes my notes on first 12 minutes of video]
banned.video ^ | Aug 5, 2021 | The Alex Jones Show, Ivory Hecker

BOMBSHELL: British Funeral Director John O'Looney: Deaths Skyrocketed '300%' After Covid Vaccine (Video)
RAIR Foundation USA ^ | October 14, 2021 | Renee Nal

Respiratory Therapist Blows Whistle: "I'm Watching People DIE" (15 minute video) [He and others meet Oct 23, Noon at the State Capitol in St. Paul, Minnesota to walk to Gov's Mansion
rumble.com ^ | October 12, 2021 | Stew Peters, Mark Bishofsky

WARNING: NURSING HOME WHISTLEBLOWER, "PATIENTS DYING LIKE FLIES AFTER VACCINE"
brighteon.com ^ | January 28, 2021 | Brighteon User: Contrarian

Witnessing the harm done by vaccines explains why so many medical people and first responders are willing to lose their jobs rather than volunteer for biowweapon injections. 

And in you snd your followers chronic posting of every breathless and unsubstantiated claim as gospel fact, it is becoming nothing more than irrelevant noise.

The plain fact is you want people to believe penumbras and shadows as gospel truth while attempting to deny the obvious. It has and is failing as the chronic drumbeat is gathering little movement.

Oh come on - the blind belief in 'gospel truth' is what your leaders, Fauci and the CDC, live by. They never prove anything. They're out there urging children and pregnant women to get a toxic experimental vaccine for a highly treatable illness to which the young are not succeptible. Instead - they push the vax. 

Your numbers are grossly inflated on logic that is faulty. You have no data. Just rantings of those with an agenda and yet you post it as if it were gospel fact. You have selected what conclusion you want and are working back from that conclusion trying to force things to for your narrative. It’s why there is zero clear evidence supporting your beliefs.

Refute Steve Kirsch's valid, defensible information and win 1 million dollars. You can prove him wrong, prove me wrong, AND win 1 million dollars! DO IT! 

Comment to ACIP meeting of August 30, 2021 submitted by Steve Kirsch (with 20 experts including Dr Malone, Dr. Vanden Bossche, Dr. McCullough, Dr. Pierre Kory, Dr. Fareed
skirsch.com ^ | August 30, 2021 | Steve Kirsch

I'm not making up data, I'm quoting experts with evidence the CDC, NIH, and FDA pretend don't exist. Zelenko, McCullough, Dr. Merrit and others are saving lives, and the CDC won't acknowldege them, other than to attack them, and won't even advise the public to make sure they get enough Vitamin D to cut RISK.

FReepers are sharing stories of 'vaccine' harm you also ignore.

LilFarmer: "I have noticed many posts of personal experiences with adverse reactions to the vaccine and thought it would be helpful to put them all in one place."
8/24/2021 | LilFarmer

It is also why I’m order for you to to be correct. That all but the dirty dozen of physicians who you regularly quote would have to be in on some conspiracy. Every physician including my colleagues on free republic would have to be coordinating our stories and lying.

Those the Biden machinery attacks are now deemed the 'dirty dozen'? Want to include all the others the Biden regime is attacking? How about the Jan 6 political prisoners he's taken. Are they 'dirty' too? Who says they are dirty? The CDC/MSM/NIH/Fauci...and YOU.

You and your fellow fake doctors are pretending there is no suppression or censorship. You know who else believes there's no censorship or suppression of medical evidence? The CDC and Fauci. Funny how that always happens, eh?

Dr. Hoffe was threatened for asking why his 900 patients, which he vaccinated, had higher rates of vaccine harm that didn't match Pfizer's trial claims. He was issued a gag order, his hospital privileges were stripped, he lost half his income and his clinic burned down. Anyone who stands up to The Plandemic Narrative is viciously attacked - and you pretend there's just a 'dirty dozen' out there making up wild lies and attaching their names, reputations to them for no reason.

But all you and your group have is that we are lying and other people have said….
Well if you believe some whistleblower with no direct clinical presence you must lend equal weight to those of us who are dismissed as anonymous physicians who are probably lying

WORLD-WIDE EVIDENCE refutes you. Clinical evidence, first person accounts, successful physicians who stand in front of a camera and take the abuse to get the word out. Entire nations report their populations are responding well to Ivermectin, the safety and efficacy of ivermectin/HCQ are extensive and well known, and then read you and your anonymous, fake doctor 'colleagues' insisting Ivermectin is useless. I'm supposed to believe fake anonymous doctors pushing the Fauci party line?

Your story has more wholes than Swiss cheese. You just are blinded by your agenda to see it.

The CDC/Fauci/NIH are weaponized. You and your kind either quote Fauci or his sources, attack the messenger or change the subject. Where's your report to refute Steve Kirsch's report?

You and the CDC et. al. pursue an agenda that is damaging the US and that's not something you regret. 

The CCP may treat its ardent supporters who are shoving the vax like they are important loyalists, or special now, but they don't mean it.

Video: Communist Professor Declares That U.S. Was Defeated In ‘Biological War’ With China CCP affiliated researcher says China “put the U.S. back in its place”
summit.news ^ | May 19, 2021 | Steve Watson

 



TOPICS: Miscellaneous
KEYWORDS: 1trumpvaccine; 2trumpvaccinated; 3qplusvaccinated; 4qplusapproved; covidvaccines; notsorare; q; qplusknowsbest; qsaysitsok; randomnut; rare; safeandeffective; toolongdidntread; unexpected
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To: phoneman08
Irrelevant, as a matter of law.

What is the rate at which samples of blood from those known to be infected, are submitted, and processed for testing of various strains?

What is the geographical distribution patients subject to those tests, and how has it changed over time?

Are the conclusions affected by the unknown percentage of asymptomatic carriers or patients with "long haul" COVID?

How much does the relative population of different alleles of the virus, in an individual patient, change over time? Is this affected by mutations of their original infection, or by poorly-defended superinfections from others?

281 posted on 10/19/2021 5:59:00 PM PDT by grey_whiskers (The opinions are solely those of the author and are subject to change with out notice.)
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To: grey_whiskers

I’m sorry. What is it you’re responding to?


282 posted on 10/19/2021 6:04:41 PM PDT by phoneman08 (qwiyrqweopigradfdz oncmccRthym,.dadfjl,dz )
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To: HypatiaTaught

What is that supposed to mean?


283 posted on 10/19/2021 6:12:27 PM PDT by MrChips ("To wisdom belongs the apprehension of eternal things." - St. Augustine )
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To: phoneman08

If you can’t figure that out, it doesn’t matter, does it?


284 posted on 10/19/2021 6:14:07 PM PDT by grey_whiskers (The opinions are solely those of the author and are subject to change with out notice.)
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To: grey_whiskers

Guess not.


285 posted on 10/19/2021 6:20:44 PM PDT by phoneman08 (qwiyrqweopigradfdz oncmccRthym,.dadfjl,dz )
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To: grey_whiskers

MORE:

Peshawar, Pakistan, from April to August 2020. ICU mortality 75-94%
The overall mortality was 77%. Non-invasive ventilation (NIV) was administered to 61.8% of patients. Mortality was higher for invasive mechanical ventilation (IMV) (93.6% vs 66.7%, p<0.001) and for over 60 years (87.3% vs 72.3%, p=0.019). Mortality without co-morbidities was 75.2%.

AND, further down, same link:

“Studies have reported nearly 100% mortality amongst patients on invasive mechanical ventilation (IMV) during the peak of the pandemic [10]. Mortality among patients on IMV was 88.6%, 97%, 43%, 31%, 88.8%, 22%, and 40%-60% in New York [7], China [11], UK [12], Spain [13], Australia [14], and India [15], respectively. With time, the mortality in ICUs declined to around 40% [4]. In the early days of the outbreak, there were no international guidelines for managing patients admitted to the ICU, and the rationing of resources based on local policies in overwhelmed ICUs might have added to divergent data”

https://www.cureus.com/articles/42534-mortality-of-patients-with-severe-covid-19-in-the-intensive-care-unit-an-observational-study-from-a-major-covid-19-receiving-hospital

memory lane “there’s nothing we can do” July 2020
https://www.youtube.com/watch?v=1dGjAkDfdO8&t=296s

Less scary numbers:

BY CFR, May 2020: overall CFR was 6.25% USA on May 15, 2020, according to OurWorldData. By April, 2021, it had dropped to 1.8% and 1.61% in Oct, ‘21. The drop is in spite of the introduction of Delta in approx May/Jun 2021. A reduction not caused by Delta getting weaker.
OurWorldData Chart:
https://ourworldindata.org/mortality-risk-covid

In one report from CDC looking at 3/1-8/1, 2020, 20% excess mortality:
Between March 1 and August 1, 2020, 1,336, 561 deaths occurred in the US, a 20% increase over expected deaths based on death data from the National Center for Health Statistics (Figure).
https://www.cdc.gov/library/covid19/pdf/2020_10_23_Science-Update_Final_Public.pdf

Refined to ‘covid only’ deaths 2020 - 11% (after 2 months of vaccinations and 6 months of refining treatment):
According to a CDC report from April 2021:
In 2020, approximately 3,358,814 deaths† occurred in the United States. From 2019 to 2020, the estimated age-adjusted death rate increased by 15.9%, from 715.2 to 828.7 deaths per 100,000 population. COVID-19 was reported as the underlying cause of death or a contributing cause of death for an estimated 377,883 (11.3%) of those deaths
https://www.cdc.gov/mmwr/volumes/70/wr/mm7014e1.htm

Anyone who promotes going back to those days of having no defenses, of no vaccines, no monoclonals, no tocilizumab, no testing, no ongoing research, and to the days of shortages of PPE, beds, O2 and personnel that existed last year, and persist this year, or who insists on transferring personal responsibility onto vaccinating kids, is off their bleeping rocker.


286 posted on 10/19/2021 6:40:58 PM PDT by blueplum ("...this moment is your moment: it belongs to you... " President Donald J. Trump, Jan 20, 2017) )
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To: blueplum

You forgot the proven efficacy of Ivermectin (over 60 studies), particularly if given early before the virus has multiplied.


287 posted on 10/19/2021 6:47:23 PM PDT by grey_whiskers (The opinions are solely those of the author and are subject to change with out notice.)
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To: blueplum
Interesting thought.

Some cynics elsewhere on the web started calling the coof virus "The Boomer Remover".

How much of the drop in fatality rates, is due to

a) the "burning up the combustible fuel" of disproportionately killing the most susceptible first

b) the spread to a much larger pool of a much less vulnerable population

Note that April 2020 was before widespread introduction of the jabs.

Did you cycle through the .gif of the Johns Hopkins time series data across many countries before and after the jabs, from ~Jan 2020 up to ~Oct 2021 (in other words, not cherry picking any small time slice coincidentally favorable to any predetermined/desired conclusion) ?

288 posted on 10/19/2021 6:51:20 PM PDT by grey_whiskers (The opinions are solely those of the author and are subject to change with out notice.)
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To: bagster

🤣🙋‍♀️


289 posted on 10/19/2021 7:13:12 PM PDT by greeneyes ( Moderation In Pursuit of Justice is NO Virtue--LET FREEDOM RING)
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To: David Chase; ransomnote
If we waited 10 years for the Covid vaccines to be available……..many many more people would have died.

Prove it, scrub.

And you just said you ain't 'pushing the vaccine'. Do you even listen to yourself?

#ReadYourOwnDiary


290 posted on 10/19/2021 7:50:33 PM PDT by bagster ("Even bad men love their mamas".)
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To: adorno
Without the vaccine, who knows how many more millions would have died.

Many fewer than you seem to think.

See the post by blueplum near the end of the thread which documents the fall in fatality rate through April 2021 which is still before the massive rollout of the jabs.

Now tell me how many would have lived if 5 Dem Governors hadn't put COVID patients into nursing homes, and if the Dems and Press hadn't done a full-court press against Ivermectin (stopped COVID in its tracks in Uttar Pradesh in India, being used in Japan and a couple of other countries).

I have links to studies showing its effectiveness.

291 posted on 10/19/2021 8:11:22 PM PDT by grey_whiskers (The opinions are solely those of the author and are subject to change with out notice.)
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To: grey_whiskers

dropping like flies to get past the first paragraph.
***********************************************************************************
I am sick to death of this type of hyperbolic exaggeration used to try and diminish the actual downside of the current situation.

These people can go suck eggs with Brandon.


292 posted on 10/19/2021 8:28:30 PM PDT by greeneyes ( Moderation In Pursuit of Justice is NO Virtue--LET FREEDOM RING)
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To: gas_dr; ransomnote
And you are not the referee.

As the smartest guy in the room, I have no choice but to be the referee.

My arguments are not nuked.

Your arguments resemble Nagasaki in the spring.

They are hardly addressed.

Not only addressed, but devastated with prejudice.


293 posted on 10/19/2021 9:12:55 PM PDT by bagster ("Even bad men love their mamas".)
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To: grey_whiskers

I made a statement of fact.

Dropping a whole bunch of names doesn’t make the fact wrong.

I don’t control who gets arrested or who doesn’t.
I don’t control the courts.


294 posted on 10/20/2021 12:08:33 AM PDT by David Chase
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To: bagster

Just because your definition of “pushing the vaccine” means any slight innuendo that may imply the vaccines might have made a difference.

Well that’s not pushing the vaccines in my world.

I don’t try to sell people on them. I don’t encourage people to take them or leave them as your peeps do.

I encourage people to make a sound choice and decide for themselves as it’s a medical decision.

I promote freedom of choice.

Some here go beyond promoting fear and daily horror of all manner of things.
For example:

Strange Life Forms living and growing in the vaccines.

ADE (Not one single case so far).

Micro Chips.

The vaccines ARE the virus.

Miscarriages and birth defects. (The numbers are still normal for any year)

And of course the favorite, the vaccinated are going to all die within 3 months, 6 months, this Fall, one year, 5 years, about 10 years from now.

Who is pushing what?

Seriously.


295 posted on 10/20/2021 12:28:20 AM PDT by David Chase
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To: David Chase
Who

David Chase.

is pushing what?

The fake poison vax.

Its like you're working on commission.

#SalesmanOfTheMonth


296 posted on 10/20/2021 4:27:33 AM PDT by bagster ("Even bad men love their mamas".)
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To: bagster

Well Good Morning Sunshine!!

Pretty early over there on the West Coast.


297 posted on 10/20/2021 4:33:44 AM PDT by David Chase
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To: David Chase

If the courts are corrupt or unreliable, you are arguing in bad faith (and knowingly so) in telling people to go to the courts.


298 posted on 10/20/2021 5:40:37 AM PDT by grey_whiskers (The opinions are solely those of the author and are subject to change with out notice.)
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To: blueplum

“According to a CDC report from April 2021:
In 2020, approximately 3,358,814 deaths† occurred in the United States. From 2019 to 2020, the estimated age-adjusted death rate increased by 15.9%, from 715.2 to 828.7 deaths per 100,000 population. COVID-19 was reported as the underlying cause of death or a contributing cause of death for an estimated 377,883 (11.3%) of those deaths
https://www.cdc.gov/mmwr/volumes/70/wr/mm7014e1.htm

A couple of notes.

Increase in age-adjusted death rate is 113.5 per 100,000 population.
There are (roughly, this is a ballpark figure for “rough and ready” conclusions) 350,000,000 people in the US.
So 350,000,000/100,000 = 350,000/100 = 3500 hundred thousands in the US.
So the increase in deaths in the US for that time frame is
113.5 x 3500 = 397, 250 (increase).
The % of that due to COVID (underlying or contributing)
is 11.3% of 397,250.
or just shy of 50,000 deaths — 44889.25.

One might make the case even more strongly by looking at the actual deaths by age cohort due to COVID.
I don’t have the link on me, but the CDC earlier showed that 78% of the dead from the coof, were over age 65, IIRC.
Or 22% of the deaths are working age (at max, discounting people under 18).
which works out to (combining with the 44889 above) 9875 people in the working population who died of the coof over and above the expected death rate.

This is not sufficient grounds to lock down the entire country and force hundreds of millions to get an experimental gene therapy.


299 posted on 10/20/2021 6:36:19 AM PDT by grey_whiskers (The opinions are solely those of the author and are subject to change with out notice.)
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To: ransomnote; Jane Long; bitt; bagster; numberonepal; Cletus.D.Yokel; Cathi; greeneyes; tatown

https://investors.modernatx.com/news-releases/news-release-details/moderna-highlights-new-clinical-data-its-covid-19-vaccine

Moderna Highlights New Clinical Data on its COVID-19 Vaccine

September 15, 2021 at 4:00 PM EDT

(snip)

Analysis of Open-Label Part of Phase 3 COVE Study (July-August 2021)

Today, Moderna is sharing a new analysis of the incidence of breakthrough COVID-19 cases among vaccinated participants in the open-label portion of the Phase 3 COVE study between July 1, 2021 and August 27, 2021. The goal of the analysis is to quantify the impact of waning immunity in the face of the Delta surge in the United States. The analysis compared participants initially randomized to mRNA-1273 (vaccinated from July-October 2020; n=14,746; median follow-up of 13 months since first dose) against participants initially randomized to placebo who were crossed over and vaccinated following Emergency Use Authorization (vaccinated from December 2020-March 2021; n=11,431; median follow-up of 8 months since first dose).

In the analysis, 88 breakthrough cases of COVID-19 occurred in the more recently vaccinated group (49.0 cases per 1000 person-years) compared to 162 cases in the group vaccinated last year (77.1 cases per 1000 person-years). The reduction in incidence rates for participants vaccinated more recently compared to participants vaccinated last year was 36% (95% CI: 17-52%). A Cox proportional hazards model showed similar results after adjusting for age and risk factors for severe COVID-19. Fortunately, only 19 severe cases were observed. While not significant, there was a numerical trend towards a lower rate of severe cases in the group vaccinated more recently (3.3 per 1000 person-years) compared to the group vaccinated last year (6.2 per 1000 person-years).

The increased risk of breakthrough in this analysis quantifies the impact of waning immunity in the COVE study between the median follow-up time of 8 months and 13 months since first dose. The Company believes this adds to evidence of potential benefit of a booster dose of mRNA-1273. A manuscript has been submitted as a preprint to medRxiv and will be submitted for peer-reviewed publication.

= = = = = = = = =

Translated, the efficacy of the shots against COVID wanes over time.
Whether due to genetic drift, ADE, or loss of antibody titer (cf the NEJM article elsewhere in this thread), I don’t yet know.
They need to repeat this study at intervals to see if the decay rate of efficacy is constant over consecutive time intervals. It’s gonna be a pain to try and disentangle the effects without (say) doing detailed blood work on those who have breakthrough cases.


300 posted on 10/20/2021 7:00:41 AM PDT by grey_whiskers (The opinions are solely those of the author and are subject to change with out notice.)
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