In the course of my seven decades, I cannot think of one area of the Natural Sciences that has not had a major upset / revelation. Properly done, a researcher probes and looks for gaps or conclusions supported more by opinion than by facts. I think one of the most perceptive comments on this subject came from Arthur C Clarke as one of his "Three Laws";
1) When a distinguished but elderly scientist states that something is possible, he is almost certainly right. When he states that something is impossible, he is very probably wrong.
2) The only way of discovering the limits of the possible is to venture a little way past them into the impossible.
3) Any sufficiently advanced technology is indistinguishable from magic.
”Scientific knowledge is a body of statements of varying degrees of certainty -- some most unsure, some nearly sure, none absolutely certain." Nobel Prize physicist Richard P. Feynman ,
The father of quantum electrodynamics.