Antibody-Dependent Enhancement Risk for SARS-CoV-2 Vaccine Developers
“Because if the gun is jumped, and a vaccine is widely distributed that is disease enhancing, that would be worse than actually not doing any vaccination at all.”
https://www.journalofinfection.com/article/S0163-4453(21)00392-3/fulltext#%20
JOURNAL OF INFECTION
TITLE:
Infection-enhancing anti-SARS-CoV-2 antibodies recognize both the original Wuhan/D614G strain and Delta variants. A potential risk for mass vaccination ?
FROM THE PAPER:
Highlights
• Infection-enhancing antibodies have been detected in symptomatic Covid-19
• Antibody dependent enhancement (ADE) is a potential concern for vaccines
• Enhancing antibodies recognize both the Wuhan strain and Delta variants
• ADE of Delta variants is a potential risk for current vaccines
• Vaccine formulations lacking ADE epitope are suggested.
**NOTE ABOUT ADE ( ANTIBODY DEPENDENT ENHANCEMENT )**
Sometimes, after developing antibodies to a disease, our immune system can overreact the next time it gets exposed to the disease. This is a very rare phenomenon called antibody-dependent enhancement (ADE).
The antibodies involved in ADE don’t help the body’s immune response, but instead might even make things worse. ADE increases the chance that a person will develop severe symptoms of a disease when they are infected.
Antibodies that lead to ADE work like a “Trojan horse” by letting the virus into the cells and making the immune response overactive. They allow the virus to attach to our cells, causing inflammation and an enhanced immune system response.
So far, Vaccine supporters say, there have been no verified reports of ADE occurring as a result of COVID-19 vaccines.