I use 2 remotes.
One for the LG tv and regular programming and the 2nd one is the ROKU remote. I use the LG remote to switch inputs to the Roku deivice then the Roku remote to select the tv apps like Sling, Netflix, prime video (Amazon) and pluto. The one I use the most is Youtube.
I go to Youtube on the computer and click on the Subscribe button for the shows I watch.
That’s what I have also. Works just fine.
I only use two as well. The one issued by Spectrum cable which controls my TV, DVR and DVD player, and my Roku remote control.