If the virus does not have major mutations by Thanksgiving (enough to make current vaccines totally useless) it will be a true shocker.
To make current vaccines useless, COVID-19 would have to mutate more than flu strains do. There is no indication that is likely. The odds of such a mutation depend on the stability of the virus and it’s numbers. It appears it has a disadvantage in the former, but an advantage in the latter. That would seem to be a wash.
Granted, we could just have really bad luck.
Life goes on.