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New NIH Hydroxychloroquine Trial Could Be Destined to Fail: The Essential Component, ZINC, is not included
PJ Media ^ | 05/15/2020 | Stacey Lennox

Posted on 05/15/2020 7:36:20 AM PDT by SeekAndFind

The politicization of hydroxychloroquine has been one of the most frustrating aspects of Trump Derangement Syndrome during this pandemic. Early studies in France and clinical outcomes from multiple treating physicians using a combination therapy that included the drug provided hope to combat the virus. However, it made President Trump hopeful, so it had to be obliterated.

Crappy studies of the drug given to the most severe patients were touted as proof the president was wrong. Then there was Fish Tank Cleaner Gate. This is the problem with political reporters covering press briefings about a pandemic. They either aren’t provided an internet connection by their employers or are too lazy to do 15 minutes of research.

Now, the NIH has finally announced it will begin a clinical trial using hydroxychloroquine and azithromycin in COVID-19 patients with mild to moderate symptoms. Every clinician who has advocated hydroxychloroquine-azithromycin has said this is the appropriate stage of the disease to use the drug combination. Dr. Vladimir Zelenko began giving it to diagnosed and presumed COVID-19 patients during a severe outbreak in New Rochelle, New York. He started the drug when patients were suffering from mild shortness of breath.

Dr. Anthony Cardillo also explained how he effectively used the drug. His method was to give the medicine with azithromycin and zinc for a specific biological reason. This mineral needs to be added to the NIH trial based on volumes of scientific research on how it works in combination with hydroxychloroquine. Cardillo explained it succinctly:

“It was actually the hydroxychloroquine opening up a channel in the cellular membranes allowing zinc to come into the cells,” he said,


(Excerpt) Read more at pjmedia.com ...


TOPICS: Health/Medicine; Science; Society
KEYWORDS: anthonycardillo; cardillo; covid19; hcq; hcqstudy; hcqtrial; hydroxychloroquine; nih; zelenko; zinc; zinczinczinc
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1 posted on 05/15/2020 7:36:20 AM PDT by SeekAndFind
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To: SeekAndFind

Why would u do this trial without the Zinc unless you intentionally wanted it to fail?


2 posted on 05/15/2020 7:38:29 AM PDT by tennmountainman (The Liberals Are Baby Killers)
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To: SeekAndFind

Looks like the only worthwhile clinical trial to look at is the one organized by Dr. Vladmiri Zelenko himself with the prestigious St. Francis Hospital in Roslyn, Long Island, New York, which will try to replicate his own successful patient cases and use his suggested protocol (yes, this INCLUDES Zinc, and will be applied to Covid-19 positive patients who are NOT hospitalized ).

Read all about it and watch the video report here:

https://newyork.cbslocal.com/2020/04/30/coronavirus-exclusive-meet-the-doctor-behind-the-hydroxychloroquine-treatment-for-covid-19/

The results will be announced by early June 2020.


3 posted on 05/15/2020 7:38:59 AM PDT by SeekAndFind (look at Michigan, it will)
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To: SeekAndFind

Okay, Keyboard Warriors, you know what to do. Expose this little scheme.


4 posted on 05/15/2020 7:39:22 AM PDT by Texas Eagle (If it wasn't for double-standards, Liberals would have no standards at all -- Texas Eagle)
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To: tennmountainman

RE: Why would u do this trial without the Zinc unless you intentionally wanted it to fail?

Because the first large scale study made by the French Doctor, Didier Raoult, which actually succeeded in over 91% of patients only used Hydroxychloroquine and Azithromycin.


5 posted on 05/15/2020 7:40:09 AM PDT by SeekAndFind (look at Michigan, it will)
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To: SeekAndFind

Every study done with HCQ / Z-Pack WITHOUT Zinc tablets has had mixed results because people have varying amounts of blood zinc depending upon their health, age, and diet.
A study that does not include Zinc is doomed (designed?) to have mixed results.


6 posted on 05/15/2020 7:43:05 AM PDT by ocrp1982
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To: tennmountainman
The reaction to hydroxychloroquine was very perplexing. The NIH studied drug’s older cousin chloroquine following the SARS epidemic. In 2005 the NIH noted chloroquine had both prophylactic effects for prevention and anti-viral effects in cell cultures:

Conclusion

Chloroquine is effective in preventing the spread of SARS CoV in cell culture. Favorable inhibition of virus spread was observed when the cells were either treated with chloroquine prior to or after SARS CoV infection. In addition, the indirect immunofluorescence assay described herein represents a simple and rapid method for screening SARS-CoV antiviral compounds.

Because of how the drug works, especially in combination with zinc, Dr. Anthony Fauci’s inability to articulate the clinical case for exploring it was quite odd. His own agency had investigated chloroquine in a dozen ways following the SARS outbreak. It makes logical sense if chloroquine could inhibit viruses in vitro that its lower-risk cousin would have a similar effect. The science was always on President Trump’s side for use of the three-drug combination in the early course of illness. Fauci’s inability to articulate it was maddening and, in my own opinion, quite suspicious.

7 posted on 05/15/2020 7:43:24 AM PDT by SeekAndFind (look at Michigan, it will)
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To: tennmountainman
They want it to fail because the drug and Zinc are low cost.

Greedy 🐷🐷🐷🐷🐷

8 posted on 05/15/2020 7:43:45 AM PDT by Pajamajan ( Pray for our nation. Thank the Lord for everything you have. Don't wait. Do it today.)
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To: ocrp1982

Yes, every successful clinician who has shared his or her success in treating patients early emphasized the role of ZINC.

Hydroxychloroquine holds the door to the cell open so zinc can run inside and stop the virus from making photocopies of itself (i.e. replicating).

They work TOGETHER to stop the viral load from increasing so the patient’s own immune system has a better shot. The NIH trial does not include the mineral. It will probably have mixed to disappointing results depending on how much ZINC level a patient has.


9 posted on 05/15/2020 7:45:42 AM PDT by SeekAndFind (look at Michigan, it will)
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To: SeekAndFind

Because zinc may not be essential. Do your homework about how HCQ alone inhibits viral penetration of cells and mitigates immune response. That’s why these tests are being done, to find out what combination works best.


10 posted on 05/15/2020 7:46:21 AM PDT by bigbob (Trust Trump. Trust the Plan)
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To: SeekAndFind

Take this to the NIH and to the PIs of the study. You are paying their salaries, and are entitled to know if they are doing the best study possible or if it is biased. It does no good to complain here.


11 posted on 05/15/2020 7:46:53 AM PDT by Kirkwood (Follow your Inner Trump)
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To: Pajamajan; All; tennmountainman

RE: They want it to fail because the drug and Zinc are low cost.

By the way good folks, if you can find ZINC, please tell me where I can buy it. My last bottle has been used up and everywhere, including Vitamin shop and Amazon — IT IS SOLD OUT !!


12 posted on 05/15/2020 7:50:56 AM PDT by SeekAndFind (look at Michigan, it will)
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To: tennmountainman

The only way you do it without zinc is if you are doing a simultaneous test with zinc. Otherwise, they are just attempting to generate propaganda to raise the death count.


13 posted on 05/15/2020 7:51:21 AM PDT by Cincinnatus.45-70 (What do DemocRats enjoy more than a truckload of dead babies? Unloading them with a pitchfork!)
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To: tennmountainman
There was a recent study using Zinc, but the media ignored it.

Drug Combo with Hydroxychloroquine Promising: NYU Study

https://www.ny1.com/nyc/all-boroughs/news/2020/05/12/nyu-study-looks-at-hydroxychloroquine-zinc-azithromycin-combo-on-decreasing-covid-19-deaths

NEW YORK - Researchers at NYU’s Grossman School of Medicine found patients given the antimalarial drug hydroxychloroquine along with zinc sulphate and the antibiotic azithromycin were 44 percent less likely to die from the coronavirus.

“Certainly we have very limited options as far as what we have seen work for this infection so anything that may work is very exciting,” said Dr. Joseph Rahimian, Infectious Disease Specialist at NYU Langone Health.

14 posted on 05/15/2020 7:54:15 AM PDT by W650
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To: bigbob

RE: Because zinc may not be essential. Do your homework about how HCQ alone inhibits viral penetration of cells and mitigates immune response.

The first large scale study made by the French Doctor, Didier Raoult, which actually succeeded in over 91% of patients only used Hydroxychloroquine and Azithromycin.

It was Dr. Zelenko who recommended its use.

But there is also one essential condition that will make or break the clinical trial -— WHEN these cocktail is administered.

If the NIH only chooses patients who are WAY ADVANCeD in their disease, i.e., in ICU or in the hospital ( what the VA study and other studies did ), the results will again be MIXED.

All successful cases applied the cocktail EARLY in the patient’s disease ( within 5 days of positive tests and/or manifestation of Covid-19 symptoms ).

Dr. Zelenko’s intent is to PREVENT hospitalization.


15 posted on 05/15/2020 7:54:46 AM PDT by SeekAndFind (look at Michigan, it will)
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To: SeekAndFind

Next: A run on zinc. Listerine has been added to the hoarding list.


16 posted on 05/15/2020 7:55:48 AM PDT by SkyDancer (~ Just Consider Me A Random Fact Generator ~ Eat Sleep Fly Repeat ~)
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To: SeekAndFind
Its pretty obvious "they" don't want a solution.

It threatens their power grab.

Nobody gets rich from a cheap, generic cocktail.

17 posted on 05/15/2020 7:57:24 AM PDT by G Larry (The People must shutdown the tyrants.)
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To: SeekAndFind

But since then, Raoult in Marseille has added Zn to the regimen. NIH is ignoring the progress that has been made toward a more reliable treatment. That’s how bureaucracy works in medicine.


18 posted on 05/15/2020 8:05:03 AM PDT by Chaguito
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To: Chaguito

RE: But since then, Raoult in Marseille has added Zn to the regimen.

Oh, I didn’t know that. Thanks for the update. Do you have a link that tells us that ( i.e., Dr. Raoult adding Zinc to his protocol ).


19 posted on 05/15/2020 8:07:41 AM PDT by SeekAndFind (look at Michigan, it will)
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To: SeekAndFind

Try to purchase zinc supplements. Or a pulse-oximeter for that matter. There seems to be no appreciable supply of either.


20 posted on 05/15/2020 8:11:19 AM PDT by one guy in new jersey
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