[RummyChick]

"Those with two copies of the Δ32 allele in the CCR5 gene are 21 percent more likely to die by age 76, although it’s not clear why. “It is very interesting to see that the [increased mortality] effect was limited to the homozygous state,” says Hans-Peter Kiem, who studies gene therapy and transplantation at Fred Hutch, in an email. It’s possible that having one copy of the mutation offers the individual wider protection against disease than two copies of either allele and therefore may be the reason for its growing prevalence in the population."

https://www.the-scientist.com/news-opinion/genetic-mutation-that-prevents-hiv-infection-tied-to-earlier-death-65960

[RummyChick]

https://www.drugdiscoverytrends.com/genetic-relic-of-the-black-death-may-offer-clues-in-treating-liver-disease/

Previous studies have suggested that the CCR5-delta mutation was enriched in people of European descent and then passed down by the survivors of the Black Death which swept Europe in the 14th century killing up to a third of its population. It confers a survival advantage to those infected with HIV because HIV uses the CCR5 receptor to enter immune cells, explains Sherman.

[RummyChick]

i guess this got retracted

https://www.the-scientist.com/news-opinion/error-in-study-linking-hiv-resistance-gene-to-increased-mortality-66504