from Dr. Seheult’s lecture:
Benefits on one side, drawbacks on the other side - are they balanced? more research is needed (but see also Canadian paper below).
The cons: hinders the manufacture of antibody triggering Cox-2, so it suppresses antibody production
The pros: may inhibit viral replication; toxic and inhibitory to influenza A and B; inhibitory to the original SARS, reduces fever/aches and pains
Canadian paper:
Key Points:
• There is insufficient evidence that NSAIDs negatively impact morbidity or mortality of COVID-19.
• Health Canada continues to recommend both ibuprofen and acetaminophen for treatment of fever due to COVID-19.1
• Evidence to date suggests that older people (>60 years of age) and those with underlying medical conditions are at higher risk of severe COVID-19 disease. As NSAIDs should also be used with caution in these populations, it is reasonable to avoid NSAIDs in the elderly and in those with comorbid conditions (e.g., cardiovascular disease, renal disease, chronic respiratory disease). If the use of an NSAID is unavoidable in these patients, it should be at the lowest effective dose and for the shortest duration.
• The CPhA monograph Nonsteroidal Anti-inflammatory Drugs (NSAIDs) contains detailed information on the contraindications, warning and precautions to consider when recommending or prescribing NSAIDs.
Thank you. Exactly what I was looking for
‘Complete chaos’ as Orange County courts reopen amidst coronavirus panic
Orange County’s first attempt to hold court hearings after a brief closure due to concerns over the spread of the coronavirus descended into “complete chaos” Thursday, with packed courtrooms seeming to fly in the face of recent guidance offered by health officials, some of the county’s top legal officials said...
...”We were not following the state guidelines for public health. We were not following the federal guidelines for public health,” Orange County Public Defender Sharon Petrosino said. “It was wall-to-wall people, everywhere you looked.”