SIDE EFFECTS/ LIABILITY :
The drug also increased the risk of stroke and potentially dangerous fluid shifts in the brain,
however, forcing a balancing act between its effectiveness and patients’ ability to tolerate a high-enough dose.
Researchers were able to catch early signs of the side effect, known as amyloid-related imaging abnormalities (ARIA),
through MRI brain scans, Salloway says, and no one in the trial suffered irreversible harm."
The “fluid shifts” are the temporary inflammatory effects as the amyloid placs are destroyed and the brain has to absorb the bi products. High dose drug doesn’t necessarily mean high fluid boluses in giving the drug.
Infammation increases in the brain causing an influx of prostaglandins, various humors, white cells as well as a local increase of cytokine waste products...thus an increase of fluid which follows causing an increase of intracranial pressure and a danger of ischemic stroke. Several days after the inflammatory process, the fluid shift would reverse reducing danger to the brain. The fluid shift into the brain can be mitigated with mannitol should ICP become too high!
“The drug also increased the risk of stroke and potentially dangerous fluid shifts in the brain”
As for the fluid, perhaps, it will just take a low dose and longer to clear the aggregated amyloid.
As for the strokes, may giving it earlier in the disease will not cause as many strokes.
“The drug also increased the risk of stroke and potentially dangerous fluid shifts in the brain”
As for the fluid, perhaps, it will just take a low dose and longer to clear the aggregated amyloid.
As for the strokes, may giving it earlier in the disease will not cause as many strokes.