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How do you explain the fact that this kitty, if a Ragdoll as the owner said, does not have a blue eye?

Ragdolls are offshoots of Siamese. They all have blue eyes. This kitty would not have the genetic information to produce brown.

As I said, do a little research on HPE. In the human babies born with such a severe defect in the spectrum, the "eye" has the same appearance. Sometimes it's actually red. The gene that is defective in HPE is responsible for the development of many, many fundamental elements of body structure. And it's a gene that operates at the most fundamental level of embryological development...the HSS gene enables the expression of other genes. If the foundation of your house is defective, it doesn't matter what color you wanted the shingles to be.

I am not a Ph.D. in embryology, but I know that I know more than you about this particular subject. So while I can't write a dissertation on every minute aspect in the generation of every physical defect this kitten was born with, I can very confidently tell you that it's real. If you want to believe that or not, I really don't care. My previous post explaining HPE was mostly directed to other readers of the thread, who may genuinely want information on what occurred, as opposed to trying to look witty when they have no idea of that of which they speak.

Here's a link to a nice presentation on HPE. Go to slide #9, and tell me (and Stanford University Medical Center) that the photo of the child in the top left is photo-shopped because the nose is above the eyes (which are, in that child, separate but in a single eye socket). I mean, the nose is supposed to be below the eyes, so we know it's fake, right?

Powerpoint on HPE

Note to all Interested Parties: DO NOT follow the link if you get easily disturbed.