My F-150 has 2 things going for it - a 36 gallon tank, and a reasonably economical twin-turbo V6. Although if you get into those turbos, the mileage drops pretty fast.
I recently drove from Manassas to Oak Ridge, Tennessee, and back. Driving a 2020 Ford F150, V-6, with a 20 gallon tank. Drove mainly on the interstates - I-64, I-81, I-40. Averaged 24 to 25 MPG.