Post-SARS-CoV-2-vaccination cerebral venous sinus thrombosis: an analysis of cases notified to the European Medicines Agency

Cerebral venous sinus thrombosis (CVST) has been described after vaccination against SARS-CoV-2. The clinical characteristics of 213 post-vaccination CVST cases notified to the European Medicines Agency are reported.

Data on adverse drug reactions after SARS-CoV-2 vaccination notified until 8 April 2021 under the Medical Dictionary for Regulatory Activities Term 'Central nervous system vascular disorders' were obtained from the EudraVigilance database. Post-vaccination CVST was compared with 100 European patients with CVST from before the COVID-19 pandemic derived from the International CVST Consortium.

In all, 213 CVST cases were identified: 187 after AstraZeneca/Oxford (ChAdOx1 nCov-19) vaccination and 26 after a messenger RNA (mRNA) vaccination (25 with Pfizer/BioNTech, BNT162b2, and one with Moderna, mRNA-1273). Thrombocytopenia was reported in 107/187 CVST cases (57%, 95% confidence interval [CI] 50%-64%) in the ChAdOx1 nCov-19 group, in none in the mRNA vaccine group (0%, 95% CI 0%-13%) and in 7/100 (7%, 95% CI 3%-14%) in the pre-COVID-19 group. In the ChAdOx1 nCov-19 group, 39 (21%) reported COVID-19 polymerase chain reaction tests were performed within 30 days of CVST symptom onset, and all were negative. Of the 117 patients with a reported outcome in the ChAdOx1 nCov-19 group, 44 (38%, 95% CI 29%-47%) had died, compared to 2/10 (20%, 95% CI 6%-51%) in the mRNA vaccine group and 3/100 (3%, 95% CI 1%-8%) in the pre-COVID-19 group. Mortality amongst patients with thrombocytopenia in the ChAdOx1 nCov-19 group was 49% (95% CI 39%-60%).

Cerebral venous sinus thrombosis occurring after ChAdOx1 nCov-19 vaccination has a clinical profile distinct from CVST unrelated to vaccination. Only CVST after ChAdOx1 nCov-19 vaccination was associated with thrombocytopenia.

Conflict of interest statement

This work received no specific grant from any fundingagency in the public, commercial, or not‐for‐profit sectors. All authors have completed the ICMJE uniform disclosure form. KK, MSK, TH, SMS, MML, KJ and JAKH have nothing to disclose. MRH reports grants from the Swiss Heart Foundation and Bangerter Foundation, travel support from Bayer, and Advisory Board honoraria from Amgen, and being a member of the ESO Board of Directors and of the ESO Education Committee. EL reports academic grants from the Swedish Neurological Society, Elsa and Gustav Lindh's Foundation, P‐O Ahl's Foundation and Rune and Ulla Amlöv's Foundation. TT reports academic grants from Sahlgrenska University Hospital, University of Gothenburg, Sigrid Juselius Foundation, Wennerström Foundation and European Union; advisory board membership/steering committee membership Bayer, Bristol Myers Squibb, Boehringer Ingelheim and Portola Pharma, lecture honorarium from University of Krems, Austria; all outside the submitted work. JP reports grants paid to his institution from the Academy of Finland, Hospital District of Helsinki and Uusimaa, and Finnish Foundation for Cardiovascular Research, consulting fees from Boehringer‐Ingelheim, Bayer and Herantis Pharma, payment for honoraria, lectures, presentations, speakers bureaus, manuscript writing or educational events from Boehringer Ingelheim, Bayer and Abbot, and stock ownership in Vital Signum. DAS reports travel support from Boehringer Ingelheim, DSMB participation for the SECRET trial, and being a member of the ESO Executive Committee. SM reports grants from Bayer paid to her institution, personal fees from Bayer paid to her institution, grants from Pfizer paid to her institution, personal fees from BMS/Pfizer paid to her institution, grants from Boehringer Ingelheim paid to her institution, personal fees from Boehringer Ingelheim paid to her institution, personal fees from Abbvie paid to her institution, personal fees from Portola/Alexion paid to her institution, grants from Daiichi Sankyo paid to her institution, and personal fees from Daiichi Sankyo paid to her institution, outside of the submitted work. MA reports honoraria for lectures from Bayer, AstraZeneca, Covidien and Medtronic, and honoraria for scientific advisory board participation from Amgen, Bayer, BMS, Daiichi Sankyo, Medtronic and Novartis. JMC reports grants paid to his institution from Boehringer Ingelheim and Bayer, and payments paid to his institution for DSMB participation by Bayer. JMF reports fees and DSMB or advisory board participation for Boehringer Ingelheim and consulting fees from Bayer. No other relationships or activities that could appear to have influenced the submitted work.

Very few acknowledged cases considering the number of people vaccinated, but a serious risk nonetheless.

TPTB won’t find what they are not looking for and they won’t look for it because they don’t want it to exist or admit that it does.

That way, they can feign ignorance and claim, no indication of _______ has yet been found. Well, no kidding, if you are not looking for it.

Anyone who trusts big pharma or the government at this point is a total fool. They have more than proved themselves completely untrustworthy by lying continually and moving the goalposts continually.

Since these cases are ADMITTEDLY not being accurately reported.....how do YOU know this is ‘very few cases, considering the number’ jabbed?

Also....what DO you consider to be an acceptable and/or significant enough “number” of deaths, to stop these clot shots?

Other shots, candy and other food products have been pulled from sales/shelved for FAR fewer deaths/adverse effects. But, these shots get a pass? For something 99.9% survivable???

“How would you know since the CDC, as a reporting agency, is untrustworthy at best, and at worst, part of a conspiracy to keep the numbers low to aid their partners in BIG PHARMA.”

You have no legitimate way to know what the actual numbers are and the CDC has no financial interest in doing so.”

You just posted a European study. I suppose the whole damn world is in on it.

Are there more cases? Almost certainly. To borrow a phrase from McDonald’s, considering the billions served, it is still a rare event.

And in case you didn’t notice in the vert study YOU posted, it is being surveilled for.

Are there more cases? Almost certainly. To borrow a phrase from McDonald’s, considering the billions served, it is still a rare event.

Still a big hairy-assed assumption on your part.

Since we know that historically, only 1% to 5% of actual injuries and deaths are reported by the CDC for a given vaccine
We also know they are filtering out incidents
We also know they are extremely dishonest where COVID-19 is concerned
We also know they have prescribed a FAKE test to confirm COVID-19, PCR, that they themselves have admitted cannot tell the difference between COVID-19 and the common every flu

Add all of that up, and anything that minimizes the number of Vaccine injuries and deaths is suspect.

“you do know they stopped giving the swine flu jab after “ only” 25 people died? We deserve to know the real numbers here....Why did they change their standards so drastically??”

Yes, I’m aware. (51 actually.) BTW, this was a “traditional vaccine so many clamor for.

In 1976, concerns in the United States about a possible influenza pandemic involving a virus similar to the deadly 1918 pandemic strain resulted in a large-scale vaccination program for the entire country. Approximately 45 million people were vaccinated in 10 weeks with what became known as the “swine flu vaccine” [16]. The US government abruptly stopped the vaccination program when no swine flu cases were detected outside the military base where the disease originated and when an unexpectedly high number of cases of Guillain-Barré syndrome were reported in vaccinated individuals. The vaccine was estimated to have caused approximately one Guillain-Barré syndrome case per 100,000 persons vaccinated [17], resulting in 53 deaths [18]. As a result of the association between the 1976 swine flu vaccine and Guillain-Barré syndrome, this condition is closely monitored every influenza season as part of the influenza vaccine safety monitoring in the United States.

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