Could you break this sentence down to vernacular terms for us non-scientists? Appreciate any additonal clarity you can provide.
With J&J, they splice the nRNA portion into the adenovirus cell. Once that is injected into the body, it begins churning out spike protein X 1, X 10, X 100, X 1000??? That is the problem.
The other two just inject the naked mRNA into the body to make spike protein. Again -— X 1, X 10, X 100, X 1000??? Still the problem.
With Novavax, they inject, for example, 100 blobs of spike protein. It is dead and can’t possibly ever make any more. It doesn’t enter the normal cells or mess with the DNA. It gives the body just enough to start antibody production, but not an overwhelming amount that might cause the body to react badly to it.
NOTHING in medicine is 100% -— but this looks like the best deal yet.