The 14th Amendment ruled out discrimination; nothing in the Constitution empowers the feds to regulate intrastate drug transactions.
Who said anything about regulating intrastate commerce? I surely didn't.
What I DID do was tell you (a couple of times) that the Necessary and Proper Clause in Article I, Section 8 of the U.S. Constitution gives Congress the power to LEGISLATE intrastate ACTIVITY in order to effectively regulate interstate commerce.
Slipped your mind, huh?