The Embargo Act - and the harm to their economic interests that resulted from it - is what caused New England to threaten to secede from the US.
This only became a terrible, rotten, evil, wicked thing to do when Southerners seceded when their economic interests were threatened with great harm (for the 2nd time) by massive tariffs lobbied for by New England based corporate interests.
Deep into my memory...this is what I remember. The War of 1812 would emerge and finally be settled by the Treaty of Trent....iirc