Effects of Astaxanthin on the Proliferation and Migration of Breast Cancer Cells In Vitro (Curbs cancer and inflammation)

Antioxidants ^ | Oct. 4, 2018 | Buckley McCall et al

[ConservativeMind]

Astaxanthin (ASX) is a marine-based pigment in plants that has many different potential functions. ASX is an antioxidant more potent than many other antioxidants. Antioxidants have anti-inflammatory and oxidative stress-reducing properties to potentially reduce the incidence of cancer or inhibit the expansion of tumor cells. We found that application of ASX significantly reduced proliferation rates and inhibited breast cancer cell migration compared to control normal breast epithelial cells.

The accessory marine-based plant pigment astaxanthin (ASX) has many different potential functions. ASX is a ketocarotenoid: carotenoids modulate cancer, reproduction, atherosclerosis, immunity, and age-related macular degeneration. Since ASX has anti-inflammatory and oxidative stress-reducing properties, in theory, the supplementation of ASX could positively affect cancer. Research shows that ASX maintains cell membrane structure while other carotenoids cause disorder in membranes. ASX has proven to decrease to both oxidative stress and inflammation in a dose-dependent manner. ASX has been able to inhibit inflammatory responses and oxidative stress via the activation of signaling pathways such as Nrf2-ARE in the brain. ASX increases brain derived neurotropic factor (BDNF) protein levels, while concurrently decreasing oxidative stress levels. ASX decreases the amount of inflammatory markers such as TNF-α, IL-6, and IFN-γ via NFκβ inhibition.

Most cancer deaths are caused by metastases where tumor cells migrate. When the cells are exposed to ASX at increasing concentrations, the distance that the cells migrated declined until the cells started to recede. MCF-7 ER+ breast cancer cells show an immediate decline in cell migration when ASX is administered. As the concentration increases, the results become significant to p < 0.01. Similar results were seen with the MDA-MB-231 TNBC cell line. The two breast cancer cell lines both showed an immediate decrease in distance migrated as soon as ASX is administered. This decrease in distance traveled continued until the highest concentration.

[ConservativeMind]

Astaxanthin is available as a supplement and in foods such as seaweed and salmon (it is the red pigment in salmon).

Thanks goes out to “gleeaikin” for finding this study.

[ConservativeMind]

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[packagingguy]

If you take it you will turn pink like a flamingo?

https://www.nature.com/articles/175942a0

Astaxanthin in the American Flamingo

[spankalib]

I just ate lunch at a seafood place. One person didn't finish their ahi tuna.

I wolfed it down for them - deelish!

Is it also in the pink in tuna's flesh? (I like salmon too, a lot!)

[LoveMyFreedom]

In case if anyone is interested.

https://bit.ly/3dj7KMK

[Jewbacca]

It also turns your skin slightly red when you take it consistently.

People buy it in Israel to protect against the Sun. No clue if it works to do that. But you can spot people because they get much darker when tanned, due to the base red color.

All the young ladies do it.

[Jewbacca]

Red.

[windcliff]

ping

[gleeaikin]

Yesterday I was making up an order for vitamins, and I noticed several with zeanthine. I checked to see if zeanthine might be better than the Astaxanthin (ASX) I have been taking with Lutein to successfully reduce my so-called “incurable” cataracts. They are now 75% better than 2 years ago. At any rate I determined ASX is much stronger than zeanthine. Then I noticed a comment that while ASX reduces apoptosis (normal cell death) in normal tissues, it may increase apoptosis in cancerous cells.

Further searching found that this seems to be true for a number of cancers and ASX also reduces metastases. So I will probably get this for my partner with prostate cancer, and my brother with colon cancer, as well as me with my imroving cataracts, A bit more research on these cancers before I place the order.

[TTFX]

I think colors have similar effects.

Greens, orange, watermelon red. These colors are similar because they can be dissolved in fat.

[Qiviut]

I had no idea what Astaxanthin (ASX) was, so I looked it up - here’s the info for anyone else who was mystified ...

Astaxanthin is a blood-red pigment and is produced naturally in the freshwater microalgae Haematococcus pluvialis and the yeast fungus Xanthophyllomyces dendrorhous (also known as Phaffia). When the algae is stressed by lack of nutrients, increased salinity, or excessive sunshine, it creates astaxanthin. Animals who feed on the algae, such as salmon, red trout, red sea bream, flamingos, and crustaceans (i.e. shrimp, krill, crab, lobster, and crayfish), subsequently reflect the red-orange astaxanthin pigmentation to various degrees.

[Oystir]

my buddy in the algae business told me about it 6 months ago. I’ve been taking Pilgrim’s Pride 10mg

[Qiviut]

👍

Thanks - on the list to consider.

At the present time, I’m taking Dr. Z’s prophylactic protocol (his brand is Z-stack ... I buy my own components) plus I’m taking supplements for healing a broken (into two pieces) kneecap. The doc has been impressed: “wow, you are a speedy healer!” so I’ll probably keep on with this ‘healing’ regimen for a few more months. I don’t want to add any more to the ‘plethora’ of pills at the present so that’s why it’s on ‘the list’. :-)

[TTFX]

If they call it asthaxdkdjd instead of algae red, people won’t know.

[gleeaikin]

I was doing some research on lycopine for my partner’s prostate cancer, and discovered that astaxanthine is
considered generally very good for health, but can have various effects on testosterone and estrogen. Since my guy is on anti-testosterone treatment I need further information from medical sources.

I was pleased to find that lycopine is found in watermelon in useful quantities, as I am currently using watermelon as part of a weight loss diet, and partner likes it too. However although red it has none of the astaxantine which along with Lutien and bilberry is reducing the effect of my “incurable” cataracts by 75%. Below is more information on astaxanthin. It appears astaxantin can actually protect the skin from excess sun exposure. Also, with 16 mg a day I still have no change in my light beige skin color although I do seem less sunburn sensitive, and I do try to not overdo exposure.

https://www.naturalgrocers.com/article/skin-health-role-lutein-zeaxanthin-lycopene-and-astaxanthin