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The Novavax Covid Vaccine Is Real Competition for Pfizer and Moderna: No serious safety problems emerged in the Novavax study, works on newer strains
Barron's ^ | 06/14/2021 | Bill Alpert

Posted on 06/14/2021 2:48:03 PM PDT by SeekAndFind

Novavax announced Monday morning that its vaccine against Covid-19 proved 90% effective in preventing the disease in a large study group.

While Novavax’s (ticker: NVAX) effectiveness level is slightly below those shown for the authorized vaccines from Moderna (MRNA) or the team of Pfizer (PFE) and BioNTech (BNTX), it far exceeds America’s third authorized shot from Johnson & Johnson (JNJ).

The Novavax vaccine was also tested at a time when more-infectious variants of the SARS-CoV-2 virus were on the rise in the U.S.—making its near-equivalent showing to the Moderna and Pfizer shots all the more impressive. Monday’s news sets Novavax up to be a strong alternative to those companies’ vaccines—and therefore an agent for price competition in developed countries and the underserved regions of the world, such as India.

[SNIP]

Novavax said that it tested its two-shot vaccination among nearly 30,000 people aged 18 and older in the U.S. and Mexico. One-third of those got placebo shots, while the rest got the company’s combination of artificial proteins mimicking the virus’s characteristic spikes, with an additive to enhance antibody formation. It’s a different technology from the messenger-RNA approach used for the Pfizer-BioNTech and Moderna shots. That could make the Novavax product easier to distribute than the mRNA vaccines, which require special cold-storage.

In the Novavax trial, 63 members of the placebo group developed Covid symptoms, compared with 14 in the vaccine group—for a prevention rate of 90.4%. By comparison, Pfizer’s vaccine was 95% effective in its big trial; Moderna’s vaccine was 94.1% effective; and J&J’s one-shot regime was 72%. While rare side effects briefly paused the use of J&J’s shot, no serious safety problems emerged in the Novavax study.

(Excerpt) Read more at barrons.com ...


TOPICS: Health/Medicine; Science; Society
KEYWORDS: covid19; novavax; vaccine
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[SNIP]

Novavax leaders were particularly proud of their product’s performance against the newer strains of the SARS-CoV-2 virus. The Pfizer and Moderna shots were tested over the summer of 2020. Novavax conducted large trials last year in South Africa and the U.K., but it didn’t start a big North American trial until late December.

“We conducted our efficacy evaluation period during a time when variants emerged in the U.S.,” chief medical officer Filip Dubovsky told listeners. Sure enough, among the Covid cases whose virus was genetically sequenced, two-thirds were of the concerning new variants. So the fact that none of the Covid cases developed more than mild symptoms was another achievement for the Novavax technology.

1 posted on 06/14/2021 2:48:03 PM PDT by SeekAndFind
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To: SeekAndFind

How the Novavax Vaccine Works

The Novavax COVID-19 vaccine, codenamed NVX-CoV2373, and also called SARS-CoV-2 rS (recombinant spike) protein nanoparticle with Matrix-M1 adjuvant, is a COVID-19 vaccine candidate developed by Novavax and the Coalition for Epidemic Preparedness Innovations (CEPI) and is undergoing trials in India under the brand name Covovax.

It requires two doses and is stable at 2 to 8 °C (36 to 46 °F) (refrigerated).

NVX-CoV2373 has been described as both a protein subunit vaccine and a virus-like particle vaccine,though the producers call it a "recombinant nanoparticle vaccine".

The vaccine is produced by creating an engineered baculovirus containing a gene for a modified SARS-CoV-2 spike protein. The spike protein was modified by incorporating two proline amino acids in order to stabilize the pre-fusion form of the protein; this same 2P modification is being used in several other COVID-19 vaccines. The baculovirus then infects a culture of Sf9 moth cells, which create the spike protein and display it on their cell membranes. The spike proteins are then harvested and assembled onto a synthetic lipid nanoparticle about 50 nanometers across, each displaying up to 14 spike proteins.

The formulation includes a saponin-based adjuvant.
2 posted on 06/14/2021 2:52:11 PM PDT by SeekAndFind
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To: SeekAndFind

Behind a paywall....


3 posted on 06/14/2021 2:53:01 PM PDT by datura
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To: SeekAndFind

...” no serious safety problems emerged in the Novavax study”...

I will continue to watch this vaccine....


4 posted on 06/14/2021 2:53:22 PM PDT by caww ( )
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To: caww

This one has had my interest for a long time - no way in Hell I’m getting any mRNA shot.


5 posted on 06/14/2021 2:55:05 PM PDT by datura
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More offers to drink from the poisoned well? After lying to us, and continuing to lie to us, about every other aspect of the Plandemic, do people think they really want to help us?

After falsifying the need for any ‘vaccine’, and exaggerating what is actually flu like risks, should we beleive anything they say about anything they ‘offer” (to make mandatory)?

After forcing 10’s of thousands to die needlessly by withholding safe, effective FDA approved medications in use for decades, are they now to be trusted? They are now luring children and pregnant women into these ‘vaccines’ even though the reports of harm mount.

They are weaponized. Norovax is not going to be their first “good deed”. Bill Gates, China, George Soros etc. still fund and direct these biowarfare efforts.

What we need, is development on treatment protocols for the cases of Antibody Dependent Enhancement (ADE) which are likely to threaten many who were ‘vaccinated’.

We also need a clear focus on treating damage from spike proteins - the ‘vaccine’ triggers the immediate production of billions which spread out in the body within 48 hours and accumulate in the organs, which are then vulnerable to attack by the body’s immune system.

They need to stop working on more bioweapons and start focusing on treatments that are going to be needed world-wide.

What we need, is development on treatment protocols for the cases of Antibody Dependent Enhancement (ADE) which are likely to threaten many who were ‘vaccinated’.

We also need a clear focus on treating damage from spike proteins - the ‘vaccine’ triggers the immediate production of billions which spread out in the body within 48 hours and accumulate in the organs, which are then vulnerable to attack by the body’s immune system.

They need to stop working on more bioweapons and start focusing on treatments that are going to be needed world-wide.


6 posted on 06/14/2021 2:56:30 PM PDT by ransomnote (IN GOD WE TRUST)
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To: SeekAndFind

So if I’m reading this right… the spike protein used to train the immune system is created in the lab?

That’s good - though there’s still the issue that it’s the spike proteins themselves (made inside the body or not) that are the issue causing the heart attacks.


7 posted on 06/14/2021 2:58:15 PM PDT by Skywise
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To: datura

myself as well....but we shall see as it moves along. They’re also working on a Covid-Flu combo vaccine.


8 posted on 06/14/2021 3:03:29 PM PDT by caww ( )
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To: SeekAndFind

Let me check... uhh, nope, still won’t take it.


9 posted on 06/14/2021 3:06:20 PM PDT by backwoods-engineer (But what do I know? I'm just a backwoods engineer.)
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To: Skywise

RE: So if I’m reading this right… the spike protein used to train the immune system is created in the lab?

Essentially, COVID-19 vaccines train the body to recognize the coronavirus, especially the spike protein that coats it, and get ready to fight the virus off.

The Novavax vaccine is made with lab-grown copies of that protein. That’s different from some of the other vaccines now widely used, which include genetic instructions for the body to make its own spike protein.

Really, what are the alternatives?

When you are infected, the virus replicates in your body billions of times.

What Novavax designed is to have a minuscule amount of the Spike protein that doesn’t self-replicate.


10 posted on 06/14/2021 3:08:10 PM PDT by SeekAndFind
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To: SeekAndFind

I looked up saponin-based adjuvant and saw that it is relatively new in human vaccines, but has been used in animal vaccines. Here is an article discussing its use in the Shingrix shingles vaccine.

https://www.medpagetoday.com/meetingcoverage/oar/74765


11 posted on 06/14/2021 3:08:43 PM PDT by LilFarmer ( )
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To: SeekAndFind

12 posted on 06/14/2021 3:09:11 PM PDT by Travis McGee (EnemiesForeignAndDomestic.com)
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To: datura

RE: Behind a paywall....

Yeah, my company paid for this subscription. But what I posted essentially is the gist of it.


13 posted on 06/14/2021 3:09:33 PM PDT by SeekAndFind
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To: backwoods-engineer; caww; ransomnote; SeekAndFind

Merriam Webster
https://www.merriam-webster.com/dictionary/vaccine
HERE IS THE ORIGINAL PRE-2020 DEFINITION:

Definition of vaccine
1: a preparation that is administered (as by injection) to stimulate the body’s immune response against a specific infectious agent or disease: such as
a: an antigenic preparation of a typically inactivated or attenuated (see ATTENUATED sense 2) pathogenic agent (such as a bacterium or virus) or one of its components or products (such as a protein or toxin)
a trivalent influenza vaccine
oral polio vaccine
Many vaccines are made from the virus itself, either weakened or killed, which will induce antibodies to bind and kill a live virus. Measles vaccines are just that, weakened (or attenuated) measles viruses.
— Ann Finkbeiner et al.
… a tetanus toxoid-containing vaccine might be recommended for wound management in a pregnant woman if [greater than or equal to] 5 years have elapsed … .
— Mark Sawyer et al.
In addition the subunit used in a vaccine must be carefully chosen, because not all components of a pathogen represent beneficial immunological targets.
— Thomas J. Matthews and Dani P. Bolognesi

HERE IS THE 2020 ADDITION:

: a preparation of genetic material (such as a strand of synthesized messenger RNA) that is used by the cells of the body to produce an antigenic substance (such as a fragment of virus spike protein)
… Moderna’s coronavirus vaccine … works by injecting a small piece of mRNA from the coronavirus that codes for the virus’ spike protein. … mRNA vaccine spurs the body to produce the spike protein internally. That, in turn, triggers an immune response.
— Susie Neilson et al.
The revolutionary messenger RNA vaccines that are now available have been over a decade in development. … Messenger RNA enters the cell cytoplasm and produces protein from the spike of the Covid-19 virus.
— Thomas F. Cozza
Viral vector vaccines, another recent type of vaccine, are similar to DNA and RNA vaccines, but the virus’s genetic information is housed in an attenuated virus (unrelated to the disease-causing virus) that helps to promote host cell fusion and entry.
— Priya Kaur
NOTE: Vaccines may contain adjuvants (such as aluminum hydroxide) designed to enhance the strength and duration of the body’s immune response.


14 posted on 06/14/2021 3:11:05 PM PDT by Travis McGee (EnemiesForeignAndDomestic.com)
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To: Travis McGee

Sort of the same evolution as when penicillin was recognized as an antibiotic when sulfur was the standard of the day. Progress happens.


15 posted on 06/14/2021 3:19:16 PM PDT by phoneman08 (qwiyrqweopigradfdz oncm,.dadfjl,dz )
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To: SeekAndFind
These quick little pharma trials do not provide sufficient information and the history of the CDC/NIH efforts to strip us of our rights and lock us down mean we have no reason to trust that they have suddenly reversed course and mean well.

The efficacy rates are useless, worse than useless as in truth the numbers are 'relative risk' and not 'absolute risk'.

So 90% effective doesn't mean you only have a 10% chance of becoming ill.

Check Your Understanding Of The "Efficacy" Claims For 'Vaccines': The Claim "95% Effective" Means A Fraction Of 1% Of The Vaccinated Are "Protected" For 2 Months

For both vaccinated and unvaccinated, the risk of becoming ill is less than 1% in these trials, which tend to test persons 18 - 55 or young for 2 weeks to 2 months. So the 'efficacy' numbers are only valid for that duration. After the trial ends, people continue to get sick and the 'efficacy' rate decreases.

As long as the FDA, CDC, NIH, and Fauci lie about these vaccines, there's no reason to trust anyone promoting them.

16 posted on 06/14/2021 3:25:45 PM PDT by ransomnote (IN GOD WE TRUST)
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To: SeekAndFind

Possible deadly inflammation?


17 posted on 06/14/2021 3:31:20 PM PDT by Bloodandgravy (Every one being allowed to learn to read, ruins in the long run not only writing but also thinking)
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To: caww

Same here. If the time comes that its “get the shot or stay out” I want one thats gone through all the testing stages and doesn’t contain unborn babies.


18 posted on 06/14/2021 3:36:46 PM PDT by airborne (Thank you Rush for helping me find FreeRepublic! )
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To: SeekAndFind
“.......combination of artificial proteins mimicking the virus’s characteristic spikes, with an additive to enhance antibody formation.”

Thanks, but I think I’ll pass.

19 posted on 06/14/2021 3:46:54 PM PDT by HandyDandy
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To: SeekAndFind

Stock down $2. today


20 posted on 06/14/2021 3:50:55 PM PDT by Oystir
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