Posted on 07/11/2020 11:18:20 AM PDT by SeekAndFind
Remdesivir is emerging as a promising treatment for the new coronavirus, and Gilead Sciences has found it works better alone than it does when combined with hydroxychloroquine.
Gilead, the pharmaceutical company behind remdesivir, said data showed the drug reduced the risk of mortality by 62 percent, compared with standard of care. In analyzing clinical outcomes of patients, Gilead found those who were treated with only remdesivir had higher rates of recovery than those who were treated with remdesivir and hydroxychloroquine.
After a median follow-up of 14 days, 57 percent of patients treated with both remdesivir and hydroxychloroquine recovered, compared with 69 percent who were given only remdesivir. The analysis was conducted following data that demonstrated chloroquine inhibits remdesivir's antiviral activity.
Administering both drugs to a patient didn't increase mortality rates during the 14-day analysis window, according to Gilead, but those patients experienced higher "rarest of adverse events." The difference was "significant" for Grade 3-4 adverse events, defined by the Food and Drug Administration (FDA) as ranging from "severe or medically significant but not immediately life-threatening" to needing "urgent intervention."
In March, President Donald Trump started touting hydroxychloroquine, an anti-malaria drug, as a "game changer," and the FDA issued an emergency use authorization to allow it to be use a treatment for COVID-19. But studies yielded mixed results about the drug's effectiveness.
Dr. Marcus Zervos, division head of infectious disease for the Henry Ford Health System, told a July 2 news conference that patients in its study were treated early. He added that hydroxychloroquine is beneficial only if treatment begins before developing serious symptoms.
(Excerpt) Read more at newsweek.com ...
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I think we can be done with all of the articles on remedies for this virus
in general and especially hydroxychloroquine the jury is not out
I don’t think there’s anybody on this website that thinks that it doesn’t work
The only way to really study the effectiveness of drugs to combat illnesses are very long-term and very detailed and expensive studies
Ok then the treatment regiment is
HCQ+Azithro+Zn in early disease
If case is progressed to ICU remdesivir
We have an adequate treatment plan. Can we get on with life
Higher rates of recovery (e.g., return on investment) for Gilead is what they mean.
Of course the company that stands to make the most money off of this drug claims it works best. Not withstanding that this drug was developed as an Ebola cure, at which it failed miserably.
This is an expensive drug that causes liver and kidney damage in search of a market.
Given the choice between an expensive, but effective drug and an inexpensive and useless drug, the wise man chooses the latter. Why bother getting well if you have to spend all your money to do so?
“After a median follow-up of 14 days, 57 percent of patients treated with both remdesivir and hydroxychloroquine recovered, compared with 69 percent who were given only remdesivir. “
What’s missing here? What was the number for the people given only hydrocloriquine?
The TRUTH about Hydoxy Chloroquin, Azithromycin and Zinc Sulfate therapy:
Dr. Vladimir Zelenko:
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Doctor Has 99.3% Survival Rate for COVID-19 Patients Urges America To Continue Reopening
https://www.youtube.com/watch?v=TFwjY0qe7ro
*******************************************
Remdesivir treatment costs $3000.00 per patient and is only about 30% successful.
HCQ, Azithromycin, Zinc Sulfate costs about $20.00
Whay are we talking Remdesiver?
It is so glaring it’s hysterical. But it will be pushed and if congressmen can get a few bucks out of it and maybe some other groups it will be the go to drug
On June 12, 2020, FDA granted an amendment to the Emergency Use Authorization for the CDC diagnostic test for COVID 19 to address global shortages of materials needed to perform the test. This amendment provides alternatives for processing the test:
Four additional extraction reagents that can be used in the existing extraction methods
An additional extraction instrument and associated reagents
A new process that can be used in place of the extraction method when materials for the current method are limited
The CDC memo on the subject can be found here: https://www.cdc.gov/coronavirus/2019-ncov/lab/virus-requests.html
My question is: Could this change in testing procedure have influenced the change in the number of positive cases reported after the date of the change? Reported cases began increasing in the middle of June, but fatalities did not show much change until very recently.
Secondly, how does the data on sensitivity and specificity compare between the recently approved changes and the prior procedure?
This is a dumb article written by a dumb and very young and naive "reporter", Jenni Fink.
What about hydroxychloroquine, zinc, and azithromycin treatment without Remdesivir?
They have Remdesivir alone, but not hydroxychloroquine without the Remdesivir.
What are the doses? This new study is coming from Gilead, the Remdesivir maker. Where is the data?
They have someone full time researching failures associated with hydroxychloroquine?
They have data for Remdesivir alone, where is the data for hydroxychloroquine alone.
If the case progressed where the lungs began to be compromised, I would use the inhaled steroid Budesonide described here:
COVID patients defend Dr. Bartlett's ‘silver bullet’ medicine regimen
http://a.msn.com/05/en-us/BB16v52a?ocid=st
Remdesivir was tried with other diseases and it didn't work. I wouldn't trust this information until I saw the actual data in an article.
Doc sez...”I’ve got good news and I’ve got bad news. The good news is you’ve helped us gain valuable information regarding the new drug mixed with the old drug. The bad news is, it made you sicker.”
“over the standard of care”. I thought there was no known standard of care for this aside from waiting it out.
There’s some evidence that anti-inflamatories such as dexamethasone, and budesonide and such, corticosteriods, can be helpful both when in early stages and in later stages when in ICU
I wonder what combining HCQ and Zinc, and some corticosteriod would do in early stages? Some early reports claimed corticosteriods taken internally would increase risk and complications, but other reports say it helps- according to the Doc you posted about a few days ago- He stated giving it early, in nebulizer, and not to wait till person was in serious trouble-
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