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To: RummyChick

in this very very long scientific article using Medcrams buzzwords...i scroll to get to the chase..in other words..give me a solution.
https://www.sciencedirect.com/science/article/pii/S2213231715000907

So your blood could go through this if you get Wuhan Flu.
The cut to the chase is:

Sounds like take some vitamins and perhaps plasma therapy

“In addition, several antioxidant enzymes (e.g. SOD, catalase) and molecules (e.g. GSH, vitamin E and C) function within RBCs to neutralise the different reactive oxygen species. These mechanisms play a role in reducing oxidative stress during normal erythropoiesis but are deregulated or overwhelmed in disease.

Protective mechanisms are also functioning in the circulation. Haptoglobin and haemopexin can scavenge free Hb and haeme respectively and are subsequently endocytosed by macrophages. However, in the case of increased haemolysis, haptoglobin and haemopexin become rapidly overwhelmed. Upon entering the cell, haeme drives the expression of HO-1, which is the rate limiting enzyme for the degradation of haeme, and ferritin, which takes up the released iron to prevent its oxidative reactions.”


455 posted on 05/06/2020 11:59:12 AM PDT by RummyChick ( Yeah, it's Daily Mail. So what.)
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To: RummyChick
and for you Drs...here is something to consider if the blood is doing what happens with thalassemia:

https://www.ncbi.nlm.nih.gov/pubmed/23383265

"The present study aimed to investigate the role of glutathione efflux transporters, namely cystic fibrosis transmembrane conductance regulator (CFTR) and multidrug resistance-associated protein 1 (MRP1), in the control of glutathione levels and protection against oxidative challenges in beta thalassemia/Hb E erythrocytes. We found that CFTR protein was expressed in the erythrocytes of beta thalassemia/Hb E patients. Treatments with GlyH-101 (50 µM), a small molecule CFTR inhibitor, and MK571 (50 µM), an MRP1 inhibitor, reduced H(2)O(2)-induced free radical generation in the erythrocytes by ∼80% and 50%, respectively. Furthermore, combined treatment with GlyH-101 and MK571 completely abolished the induction of reactive oxygen radicals. "

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COVID-19 early warning score: a multi-parameter screening tool to identify highly suspected patients

https://www.medrxiv.org/content/10.1101/2020.03.05.20031906v1.full.pdf
457 posted on 05/06/2020 12:11:53 PM PDT by RummyChick ( Yeah, it's Daily Mail. So what.)
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