Not until 1945 was an effective use of bioweapons contemplated. Occupation searchers uncover large stockpiles of viruses, spirochetes, and fungus spores throughout rural Japan. These biological pathogens had already been tested on several hundred thousand people in Chinese villages and on prisoners of war. Civilian militias were to stay behind advancing Americans to infuse pathogens into food and waters sources, to release infected animals and insects into American compounds, and to infect themselves with choleras and plaque germs.
Slavery would have been progressive social reformation to the New World. Tribes like the Aztecs slaughtered thousands in sacrifices to their gods. The Caribs killed and ate members of other tribes but brought the women to their villages. Here they were impregnated, and their babies roasted as a delicacy.
Looks like a great article. I put a copy in my copy of The Log of Christopher Columbus.
Japan thought about doing biowarfare here.
https://en.wikipedia.org/wiki/Operation_Cherry_Blossoms_at_Night