I would ask what Rome means.
Romes arms reached out around the world, back then.
Today, the new Rome is America.
That is my best guess and it reconciles.
So America cannot be ruled out as End-Time Babylon.
At least we have it narrowed down to two option, The EU as the final Holy Roman Empire or America, Francis is now getting involved with your political system, being the first occupant of The Vatican to address Congress.
I refuse to call him The Pope, as a Roman Catholic, Pope Benedict XVI is my Pope.