Keyword: type1diabetes

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  • Type 1 Diabetes Breakthrough with Artemisinin Treatment

    12/05/2016 7:18:10 AM PST · by posterchild · 7 replies
    The Diabetic News ^ | Dec 3, 2016
    Researchers have announced that FDA-approved artemisinins, used for decades to treat malaria, offer a completely new therapy for type 1 diabetes. It promises to be a simple and elegant strategy to heal diabetes type 1: Replacing the destroyed beta-cells in the bodies of patients with newly-produced insulin-secreting cells. For years, researchers around the world tried various approaches with stem- or adult cells in order to induce this transformation. Their effort lead to a fundamental understanding of the molecular mechanisms involved in the development of beta cells – however, a compound capable of doing the trick was missing
  • First Patient in Diabetes Trial is now Diabetes-Free

    03/25/2016 2:35:02 PM PDT · by Lizavetta · 33 replies
    True Activist ^ | 3/16/16 | Brianna Acuesta
    In a new clinical trial to observe a new method of injecting islet cells into a patient with Type 1 diabetes, doctors from the University of Miami’s Diabetes Research Institute have confirmed that their first trial patient no longer needs insulin therapy. Wendy Peacock, their first patient, has been giving herself insulin injections and following a strict daily schedule to take care of her diabetes since she was diagnosed with Type 1 diabetes at 17. Now 43, Peacock has undergone the surgery in this new trial and no longer needs injections because her body is producing insulin naturally. Since the...
  • NBC News comes to Cochise County

    05/18/2015 6:18:34 AM PDT · by SandRat · 3 replies
    Sierra Vista Herald ^ | Robert Charette
    The Chiricahua Community Health Center’s mobile clinic has been a boon for the region in recent years since it’s designed to treat rural and low income areas like those found in Cochise County. The clincs are empowered by grants from the national Children’s Health Fund, which made possible the story that NBC News will tell the world this week about Buena rising sophomore Efrain Gonzalez II. The mobile clinic treats Gonzalez for Type 1 Diabetes, which allows him to backpaddle into pass coverage just like any other defender in one of the Colts’ last football practices of the school year.
  • Possible Cure for Type 1 Diabetes Announced

    08/31/2014 1:18:08 PM PDT · by nickcarraway · 34 replies
    Daily Call ^ | August 30. 2014 | Jennifer Runyon
    I know this is a loaded and extremely controversial topic but there’s been a big break in the diabetes world. I thought it needed to be shared because no matter how you feel, it’s a big deal! ViaCyte Inc. has been given FDA approval to begin clinical trials on beta cell encapsulation. You may be wondering why this is a big deal. You see, in Type 1 diabetes the body’s own immune system attacks beta cells found in the pancreas. These beta cells produce insulin and the attack makes them unable to do that. Because the body can no longer...
  • Skin drug shows 'promising' results on type 1 diabetes

    09/22/2013 5:14:00 PM PDT · by Innovative · 4 replies
    BBC ^ | Sept 22, 2013 | BBC
    A drug that was used to treat a skin disorder has shown signs of being able to treat aspects of type 1 diabetes. A small trial on US patients suggests that alefacept helps the body produce its own insulin, which is key for people with type 1 diabetes.
  • Key Protein Accelerates Diabetes in Two Ways

    08/28/2013 1:27:20 PM PDT · by neverdem · 20 replies
    ScienceDaily ^ | Aug. 25, 2013 | NA
    The same protein tells beta cells in the pancreas to stop making insulin and then to self-destruct as diabetes worsens, according to a University of Alabama at Birmingham (UAB) study published online today in the journal Nature Medicine. Specifically, the research revealed that a protein called TXNIP controls the ability of beta cells to make insulin, the hormone that regulates blood-sugar levels. "We spent years confirming that TXNIP drives beta-cell death in both Type 1 and Type 2 diabetes," said Anath Shalev, M.D., director of the UAB Comprehensive Diabetes Center and senior author of the paper. "We were astounded to...
  • One Step Forward for DIY Health Care (Walter Russell Mead)

    08/22/2013 7:08:06 AM PDT · by neverdem · 3 replies
    The American Interest ^ | August 14, 2013 | Walter Russell Mead
    The California Supreme Court has ruled that public schools can give insulin injections to students without bringing in nurses. Prior to the ruling, some schools in the state required that shots only be given by licensed professionals, but the skewed nurse-to-student ratio was hampering children’s ability to get routine care. Parents with diabetic children sued for relaxed standards, and in the higher court, they won. LA Times: Laura Mecoy, mother of two teenagers with diabetes and a Los Angeles board member of a diabetes foundation, said the ruling “delivered a wonderful back-to-school present to our children.”“As a working parent, I...
  • Insulin Pumps Better Than Injections for Kids With Type 1 Diabetes: Study

    08/21/2013 8:35:55 PM PDT · by neverdem · 2 replies
    Over a median of 3.5 years, the devices worked better at controlling blood sugar, researchers say Devices called insulin pumps may work better at controlling blood sugar in children with type 1 diabetes than insulin injections, a new study finds. They might also cause fewer complications, the Australian researchers said. "This is the largest study of insulin-pump use in children," wrote a team led by Dr. Elizabeth Davis of the Princess Margaret Hospital for Children in Perth. "It also has the longest follow-up period of any study of insulin-pump therapy in children. Our data confirm that insulin-pump therapy provides an...
  • Interspecies Transplant Paves the Way for Diabetes Therapy

    07/20/2013 1:38:27 PM PDT · by neverdem · 24 replies
    Voice of America ^ | July 20, 2013 | Jessica Berman
    Researchers have come closer to the “Holy Grail” of treatment for people with type 1 diabetes. They have successfully transplanted insulin-producing islet cells from one species into another without the use of immunity-suppressing drugs. In the future this could provide an unlimited supply of tissue to treat people whose bodies cannot produce insulin. Insulin is a hormone produced by the pancreas that delivers glucose - a form of sugar that the body uses for fuel - to cells for energy. Since the immune systems of people with type 1 diabetes attack and destroy the islet cells that produce insulin, many...
  • What and when babies first eat may affect diabetes risk

    07/13/2013 7:05:27 PM PDT · by neverdem · 6 replies
    Science News ^ | July 11, 2013 | Nathan Seppa
    Children predisposed to type 1 diabetes are better off waiting until 4 months of age to consume solid foods Infants at risk of type 1 diabetes who receive their first solid foods between ages 4 months and 6 months appear less likely to develop the condition than others given solid food before or after that time window, a new study finds. Type 1 diabetes, which can strike children at any age, occurs when an aberrant immune reaction kills cells in the pancreas, requiring a person to take insulin shots. Two studies in 2003 found an association between early first foods...
  • New Type 1 diabetes vaccine shows promising results

    06/27/2013 3:53:11 PM PDT · by neverdem · 4 replies
    CBS News ^ | June 27, 2013 | MICHELLE CASTILLO
    A clinical trial for a Type 1 diabetes vaccine has resulted in promising findings, suggesting there may be a future where we can prevent people from getting the disease. Researchers completed a 12-week trial on a DNA-based vaccine on 80 subjects with Type 1 diabetes. The patients were able to maintain levels of a blood-borne intermediary that can stimulate insulin production, and some subjects were able to increase levels. That suggests the cellular changes that occur in patients with Type 1 diabetes may be shut down.  "We're very excited by these results, which suggest that the immunologist's dream of shutting...
  • Doctors make progress toward ‘artificial pancreas’

    06/23/2013 5:28:26 AM PDT · by Olog-hai · 3 replies
    Associated Press ^ | Jun 22, 2013 4:45 PM EDT | Marilynn Marchione
    Doctors are reporting a major step toward an “artificial pancreas,” a device that would constantly monitor blood sugar in people with diabetes and automatically supply insulin as needed. A key component of such a system—an insulin pump programmed to shut down if blood sugar dips too low while people are sleeping—worked as intended in a three-month study of 247 patients. This “smart pump,” made by Minneapolis-based Medtronic Inc., is already sold in Europe, and the U.S. Food and Drug Administration is reviewing it now. Whether it also can be programmed to mimic a real pancreas and constantly adjust insulin based...
  • Immune Protein Could Stop Diabetes in Its Tracks, Discovery Suggests

    05/30/2013 5:06:32 PM PDT · by neverdem · 7 replies
    ScienceDaily ^ | May 20, 2013 | NA
    Melbourne researchers have identified an immune protein that has the potential to stop or reverse the development of type 1 diabetes in its early stages, before insulin-producing cells have been destroyed. The discovery has wider repercussions, as the protein is responsible for protecting the body against excessive immune responses, and could be used to treat, or even prevent, other immune disorders such as multiple sclerosis and rheumatoid arthritis. Professor Len Harrison, Dr Esther Bandala-Sanchez and Dr Yuxia Zhang led the research team from the Walter and Eliza Hall Institute's Molecular Medicine division that identified the immune protein CD52 as responsible...
  • Biomaterial Shows Promise for Type 1 Diabetes Treatment

    05/13/2013 11:43:36 PM PDT · by neverdem · 5 replies
    ScienceDaily ^ | May 9, 2013 | NA
    Researchers have made a significant first step with newly engineered biomaterials for cell transplantation that could help lead to a possible cure for Type 1 diabetes, which affects about 3 million Americans. Georgia Tech engineers and Emory University clinicians have successfully engrafted insulin-producing cells into a diabetic mouse model, reversing diabetic symptoms in the animal in as little as 10 days. The research team engineered a biomaterial to protect the cluster of insulin-producing cells -- donor pancreatic islets -- during injection. The material also contains proteins to foster blood vessel formation that allow the cells to successfully graft, survive and...
  • Global Surge in Type 1 Diabetes Still an Enigma

    03/27/2013 11:47:37 PM PDT · by neverdem · 16 replies
    Everyday Health ^ | March 22, 2013 | Johannah Sakimura
    Though theories abound, scientists still don't understand what is causing the rise in type 1 diabetes in children worldwide. The incidence of type 1 diabetes in children is on the rise worldwide, with the number of new cases growing by an average of 3% per year in youth under age 15. The reasons for the sharp increase remain a medical mystery, since researchers have not been able to identify the changing conditions that are causing more kids to be diagnosed in recent decades. A new study presented this week at the annual Society for Endocrinology conference may help shed more light...
  • Diabetes Reversal In Mice Via Stem Cells

    03/07/2013 3:15:32 PM PST · by neverdem · 18 replies
    redOrbit ^ | June 28, 2012 | Connie K. Ho
    Diabetes is a detrimental disease. In order to combat the illness, University of British Columbia (UBC) researchers conducted a study with an industry partner and discovered that stem cells can reverse Type 1 diabetes in mice. The discovery leads the way for the development of innovative treatments of diabetes, which is caused by deficient production of insulin by the pancreas. Insulin allows glucose to be held by the bodyÂ’s muscle, fat, and liver; in turn, itÂ’s used as fuel for the body. Blindness, heart attack, kidney failure, nerve damage, and stroke are possible consequences of low insulin production. The research...
  • Vitamin D deficiency linked to Type 1 diabetes

    11/27/2012 11:24:52 AM PST · by neverdem · 28 replies
    Science Codex ^ | November 15, 2012 | NA
    A study led by researchers from the University of California, San Diego School of Medicine has found a correlation between vitamin D3 serum levels and subsequent incidence of Type 1 diabetes. The six-year study of blood levels of nearly 2,000 individuals suggests a preventive role for vitamin D3 in this disease. The research appears the December issue of Diabetologia, a publication of the European Association for the Study of Diabetes (EASD). "Previous studies proposed the existence of an association between vitamin D deficiency and risk of and Type 1 diabetes, but this is the first time that the theory has...
  • Study: 1 in 4 kids diabetic or pre-diabetic

    05/21/2012 10:06:13 PM PDT · by neverdem · 20 replies
    KFVS (CAPE GIRARDEAU, MO) ^ | May 21, 2012 | Christy Millweard
    CAPE GIRARDEAU, MO (KFVS) - Recent data shows a shocking jump in youth diabetes. A new study in the Journal of the American Academy of Pediatrics said 1 out of 4 youth in the U.S. is diabetic or pre-diabetic. The study looked at kids under 20 years old. It showed between 2000 and 2008, the percentage of teens with pre-diabetes and diabetes jumped from nine to 23 percent. Local Diabetes Educator Janet Stewart at Southeast Health said in the past decade she's seen the number of kids with Type 1 or Type 2 diabetes jump almost 30 percent. She said...
  • Scientists Shed New Light On Link Between 'Killer Cells' and Diabetes

    01/16/2012 9:04:30 PM PST · by neverdem · 18 replies
    ScienceDaily ^ | Jan. 15, 2012 | NA
    Killer T-cells in the human body which help protect us from disease can inadvertently destroy cells that produce insulin, new research has uncovered. The study provides the first evidence of this mechanism in action and could offer new understanding of the cause of Type 1 diabetes. Professor Andy Sewell, an expert in human T-cells from Cardiff University's School of Medicine worked alongside diabetes experts from King's College London to better understand the role of T-cells in the development of Type 1 diabetes. The team isolated a T-cell from a patient with Type 1 diabetes to view a unique molecular interaction...
  • Chemical produced in pancreas prevented and reversed diabetes in mice (Type 1)

    06/28/2011 10:13:18 AM PDT · by decimon · 10 replies
    St. Michael's Hospital ^ | June 28, 2011 | Leslie Shepherd
    A chemical produced by the same cells that make insulin in the pancreas prevented and even reversed Type 1 diabetes in mice, researchers at St. Michael’s Hospital have found. Type 1 diabetes, formerly known as juvenile diabetes, is characterized by the immune system’s destruction of the beta cells in the pancreas that make and secrete insulin. As a result, the body makes little or no insulin. The only conventional treatment for Type 1 diabetes is insulin injection, but insulin is not a cure as it does not prevent or reverse the loss of beta cells. A team led by Dr....
  • Study challenges "carb counting" in diabetes

    03/12/2011 5:58:08 PM PST · by decimon · 41 replies
    Reuters ^ | March 11, 2011 | Frederik Joelving
    NEW YORK (Reuters Health) – How many carbs you eat might be less important for your blood sugar than your food's glycemic load, a measure that also takes into account how quickly you absorb those carbs. That's the conclusion of a new study of healthy adults, which questions the way people with type 1 diabetes determine how much insulin they should take before meals. In type 1 diabetes, which affects about 3 million Americans, the pancreas doesn't produce sufficient amounts of the hormone insulin, which helps ferry sugar from the blood into cells. So people with the disease are quickly...
  • Gene linked to autoimmune diseases - Rare variants of a single gene seem to make patients...

    06/17/2010 9:11:03 PM PDT · by neverdem · 37 replies · 607+ views
    Nature News ^ | 16 June 2010 | Alla Katsnelson
    Differences in the sequence of a single gene may be partly responsible for causing around 2% of relatively common autoimmune disorders including diabetes and arthritis. The gene codes for an enzyme called sialic acid acetylesterase (SIAE) that regulates the immune system's B cells — the cells responsible for producing antibodies against foreign invaders. In 24 of 923 people with conditions such as Crohn's disease, type 1 diabetes, rheumatoid arthritis, systemic lupus erythematosus and multiple sclerosis, the gene was present in a variant form. For the past five years, genome-wide screens of large groups of patients have searched for commonly occurring...
  • Vit. B link to diabetic kidney malfunction: study

    04/28/2010 6:35:01 PM PDT · by decimon · 23 replies · 606+ views
    AFP ^ | Apr 27, 2010 | Unknown
    Patients with diabetic nephropathy, kidney disease caused by diabetes and treated with high doses of vitamin B, suffered rapid deterioration of the kidneys, a recent study has found. Diabetics in addition to kidney function loss also were affected by higher rates of heart attack and stroke than those who took a placebo, according to the clinical research in the April 28 edition of the Journal of the American Medical Association (JAMA). Diabetic nephropathy affects the network of tiny blood vessels in the glomerulus, a structure in the kidney made of capillary blood vessels, which is needed to filter blood. Despite...
  • Insulin-producing cells can regenerate in diabetic mice - Discovery suggests potential treatment...

    04/09/2010 6:21:17 PM PDT · by neverdem · 7 replies · 393+ views
    Science News ^ | April 4th, 2010 | Tina Hesman Saey
    Insulin-producing cells can regenerate in diabetic mice Discovery suggests potential treatment strategy for type 1 diabetes Replacements for some diabetics’ missing insulin-producing cells might be found in the patients’ own pancreases, a new study in mice suggests. Alpha cells in the pancreas can spontaneously transform into insulin-producing beta cells, researchers from the University of Geneva in Switzerland report online in Nature April 4. The study, done in mice, is the first to reveal the pancreas’s ability to regenerate missing cells. Scientists were surprised to find that new beta cells arose from alpha cells in the pancreas, rather than stem cells....
  • Vaccine works against type 1 diabetes in mouse experiments - Researchers find self-regulating...

    04/09/2010 5:19:19 PM PDT · by neverdem · 23 replies · 470+ views
    Science News ^ | April 8th, 2010 | Tina Hesman Saey
    Researchers find self-regulating feature of immune system Weakness can be a strength when it comes to keeping the immune system from attacking the body’s own cells, mouse experiments that use a new vaccine against type 1 diabetes reveal. The new research, published online April 8 in Immunity, describes previously unknown cells that keep the immune system in check. The study demonstrates that the immune system is already outfitted with tools that can defuse destructive autoimmune reactions without damaging the body’s ability to fight infections. And it suggests that harnessing those tools may be a successful strategy for developing a vaccine...
  • Appetite Suppressor Could Be an Alternative to Insulin (PDF link in article)

    03/04/2010 6:11:14 PM PST · by neverdem · 23 replies · 902+ views
    ScienceNOW ^ | March 1, 2010 | Jennifer Couzin-Frankel
    In 1922, a Toronto teenager with diabetes became the first person to be saved by insulin treatment, and since then injections have sustained millions of diabetics, who don’t make their own hormone. But are there alternatives to a lifetime of insulin therapy? A new study suggests that an appetite-suppressing hormone called leptin is just as effective as insulin at controlling diabetes in mice. The discovery of insulin transformed type 1 diabetes from a fatal to a chronic disease. In this type of diabetes, the body destroys insulin-producing cells in the pancreas, resulting in high blood glucose levels. (The more common...
  • 'Artificial pancreas' could remove multiple daily finger prick tests for children

    02/20/2010 9:12:52 PM PST · by neverdem · 11 replies · 398+ views ^ | February 9, 2010 | Karen Sprey
    'Artificial pancreas' could remove multiple daily finger prick tests for children with type 1 diabetes An artificial pancreas system being developed by scientists at Cambridge in the UK could help safely manage type 1 diabetes in children. The new system combines a commercially available continuous glucose monitor and an insulin pump, and uses a sophisticated algorithm which calculates the correct amount of insulin to deliver based on real-time glucose readings. The research team found that using an artificial pancreas system overnight can significantly reduce the risk of hypoglycemia, or "hypos", when blood glucose levels drop dangerously low, while sleeping. "Hypos"...
  • Mussel proteins inspire new diabetes treatment

    12/10/2009 3:19:21 PM PST · by neverdem · 3 replies · 451+ views
    Chemistry World ^ | 10 December 2009 | Nina Notman
    A natural glue that sticks mussels to rocks and boat hulls has inspired US scientists to develop a new type of medical adhesive for use in pancreatic islet transplantation, an experimental medical procedure for treating patients with type 1 diabetes. The glue, developed by Phillip Messersmith's team at Northwestern University in Evanston, consists of a branched poly(ethylene glycol) core with catechol-derived end groups. Speaking at the Materials Research Society's meeting in Boston last week, Messersmith explained that the catechol functional group plays a key role in the solidification and adhesive capabilities of the marine blue mussel Mytilus edulis' adhesive proteins. 'Catechol in the presence of an...
  • A Stem-Cell Discovery Could Help Diabetics

    09/07/2009 5:57:01 PM PDT · by neverdem · 23 replies · 1,314+ views
    Time ^ | Sep. 02, 2009 | Alice Park
    Researchers are inching ever closer to bringing the latest stem-cell technologies from bench to bedside — and are, in the process, learning more about some diseases that long have remained medical black boxes. This week, scientists at the Harvard Stem Cell Institute (HSCI) reported the first success in generating new populations of insulin-producing cells using skin cells of Type 1 diabetes patients. The achievement involved the newer embryo-free technique for generating stem cells, and marked the first step toward building a treatment that could one day replace a patient's faulty insulin-making cells with healthy, functioning ones. (See the top 10...
  • A 3,000-Mile Triumph, Spurred on by Diabetes

    06/30/2009 1:01:41 PM PDT · by neverdem · 9 replies · 494+ views
    NY Times ^ | June 30, 2009 | TARA PARKER-POPE
    Last week, a team of eight cyclists completed the coast-to-coast bike marathon called the Race Across America in record time. It was quite an achievement under any circumstances, but what made it extraordinary was something all eight of them had in common: Type 1 diabetes. Type 1, sometimes called juvenile diabetes, poses special challenges for athletes. A person with Type 1 can’t produce insulin and must take regular injections to control blood sugar. But exercise can also lead to precipitous, even deadly, drops in blood sugar. (Type 2 diabetes, by far the more common form of the disease, typically develops...
  • Vitamin C helps stop diabetes damage

    06/10/2009 8:34:47 PM PDT · by neverdem · 23 replies · 1,270+ views
    Times of India ^ | 10 Jun 2009 | NA
    WASHINGTON: Harold Hamm Oklahoma Diabetes Center researchers have found a link between taking vitamin C with insulin and stopping blood vessel damage caused by type 1 diabetes. While neither therapy produced desired results when used alone, the combination of insulin to control blood sugar together with the use of Vitamin C, stopped blood vessel damage caused by the disease in patients with poor glucose control, said researchers. The findings appear this week in the Journal of Clinical Endocrinology and Metabolism. "We had tested this theory on research models, but this is the first time anyone has shown the therapy's effectiveness...
  • Narcolepsy: A Case of the Body Attacking Itself?

    05/05/2009 9:51:29 AM PDT · by neverdem · 5 replies · 522+ views
    ScienceNOW Daily News ^ | 4 May 2009 | Gisela Telis
    Enlarge ImageMystery disease. Scientists monitor a narcoleptic patient. Credit: Donna E. Natale Planas/Miami Herald/MCT/Newscom The millions of people who suffer from narcolepsy might have their immune system to blame. Researchers have tied the disabling sleep disorder to two immune system genes, suggesting that it's an autoimmune disease. The discovery may eventually lead to improved narcolepsy treatments. Narcolepsy affects 1 in every 2000 people, making it about as common as multiple sclerosis. The disorder encompasses an odd constellation of symptoms, including overwhelming daytime drowsiness, uncontrollable sleep attacks, and cataplexy, a sudden loss of muscle tone after an intense emotional outburst,...
  • Study: Stem Cells May Reverse Type 1 Diabetes

    04/15/2009 4:25:48 PM PDT · by neverdem · 15 replies · 715+ views
    Time ^ | Apr. 14, 2009 | Alice Park
    Researchers have used injections of patients' own stem cells to reverse the course of type 1 diabetes, reports a research team from the University of Săo Paulo in Brazil and Northwestern University in Chicago. The findings, published in the current issue of the Journal of the American Medical Association, exemplify the remarkable gains made by diabetes researchers, who are battling a continuously spreading disease that now affects nearly 8% of adults and children. (See the top 10 medical breakthroughs of 2008.) The research team, led by Dr. Julio Voltarelli of the University of Sao Paulo, is the first to successfully...
  • Common infant virus may trigger type 1 diabetes

    12/26/2008 11:06:39 PM PST · by neverdem · 4 replies · 568+ views ^ | December 18, 2008 | NA
    Human parechovirus is a harmless virus which is encountered by most infants and displays few symptoms. Suspected of triggering type 1 diabetes in susceptible people, research methods need to take this "silent" virus into consideration. This comes from findings in a study from the Norwegian Institute of Public Health. This study was part of a long-term project at the Norwegian Institute of Public Health to investigate if environmental risk factors affect type 1 diabetes. Faecal samples and questionnaires about the health of 102 children were sent in monthly by their parents for closer study. Researchers wanted to see how common...
  • New scientific knowledge on juvenile diabetes

    12/17/2008 1:10:01 PM PST · by neverdem · 5 replies · 369+ views ^ | Dec 17, 2008 | NA
    Finnish scientists have reported a breakthrough in the attempts to understand the development of type 1 diabetes. They discovered disturbances in lipid and amino acid metabolism in children who later progressed to type 1 diabetes, also known as juvenile diabetes. The alterations preceded the autoimmune response by months to years. The study may prompt new approaches for prediction and prevention of type 1 diabetes in pre-autoimmune phase of the disease. The results of the Finnish research team, which consists of scientists from VTT Technical Research Centre of Finland and the Universities of Turku, Oulu and Tampere, have been published on...
  • AAT Protein Restores Blood Glucose in Type 1 Diabetes Model

    10/15/2008 12:18:38 PM PDT · by neverdem · 8 replies · 585+ views
    Discovery offers further evidence of inflammation’s role in the disease; suggests new option for clinical testing Date: 10/13/2008 BIDMC Contact: Bonnie Prescott Phone: (617) 667-7306 Email: BOSTON – A protein made by the liver in response to inflammation and used to treat patients suffering from a genetic form of emphysema has been shown to restore blood glucose levels in a mouse model of Type 1 diabetes mellitus, according to a new study led by researchers at Beth Israel Deaconess Medical Center (BIDMC). The findings, which appear in the Online Early Edition of the Proceedings of the National Academy of...
  • Suspected cause of type 1 diabetes caught "red-handed" for the first time

    05/10/2008 4:36:30 PM PDT · by neverdem · 23 replies · 187+ views
    Michael Purdy Senior Medical Sciences Writer (314) 286-0122 Scientists at Washington University School of Medicine in St. Louis working with diabetic mice have examined in unprecedented detail the immune cells long thought to be responsible for type 1 diabetes. Researchers were able to examine the immune cells from isolated insulin-making structures in the pancreas known as the islets of Langerhans. They caught the immune cells, known as dendritic cells, "red-handed" carrying insulin and fragments of insulin-producing cells known as beta cells. This can be the first step toward starting a misdirected immune system attack that destroys the beta cells,...
  • Broncos quarterback Cutler diagnosed with Type 1 diabetes

    05/02/2008 4:25:47 AM PDT · by Perdogg · 19 replies · 128+ views ^ | 05.02.08 | By PAT GRAHAM
    Denver Broncos quarterback Jay Cutler has been diagnosed with Type 1 diabetes, his business manager Marty Garafalo confirmed Thursday night. The 25-year-old Cutler found out about two weeks ago that he was diabetic and needed daily insulin injections, Garafalo told The Associated Press. He said Cutler was managing his disease and "in no way is his football career jeopardized." Some 21 million Americans have diabetes, meaning their bodies cannot properly turn blood sugar into energy. Either they don't produce enough insulin or don't use it correctly. With the Type 1 form, the body's immune system attacks insulin-producing pancreatic cells, so...
  • Cell regeneration brings hope for diabetics - Mice can regenerate insulin-producing cells.

    01/25/2008 8:36:30 PM PST · by neverdem · 3 replies · 68+ views
    Nature News ^ | 24 January 2008 | Heidi Ledford
    One treatment for diabetes would be to promote the production of new insulin-making cells.MoodboardSome cells in the adult pancreas can, in times of extreme stress, produce new insulin-secreting cells, researchers have found. The findings, based on work performed in mice, open up a new approach to replacing insulin-secreting cells in patients with diabetes. They also address a raging controversy within the diabetes research community over whether such cells even exist. “It’s a big discovery,” says Emmanuel Baetge, chief scientific officer of Novocell, a stem cell company based in San Diego, California who was not involved with the work. “I think...
  • Studies at Johns Hopkins University with Expanded Adult Stem Cells for Type 1 Diabetes Treatment

    11/26/2007 9:59:29 PM PST · by Coleus · 6 replies · 70+ views
    BusinessWire ^ | November 14, 2007 | Timmie Wang
    HOUSTON--(BUSINESS WIRE)--Regenetech®, Inc. today announces that it has signed a Sponsored Research Agreement (SRA) with Johns Hopkins University in order to work toward a treatment for type 1 diabetes. This is in addition to the research agreements which the Company currently has in place with Texas A&M University and the University of Texas Medical Branch at Galveston. Regenetech is pioneering the development and commercialization of technology which the company believes will enable regenerative therapy with adult stem cells for widespread use. Regenetech’s agreement with Johns Hopkins University will span over two years, and involves significant funding from the Company. The...
  • John Hopkins University research leads to diabetes-treating implant

    05/12/2007 4:46:37 AM PDT · by CarrotAndStick · 6 replies · 595+ views
    Engadget ^ | 12th May, 2007 1:56AM | Engadget
    Although a number of unique diabetes treatments are already in the works, researchers at Johns Hopkins University are giving it a shot of their own with a newfangled intravascular implant. A team of undergrads have collaborated with doctors and biomedical engineers to develop a "specialized implant for a potential treatment of type I diabetes," which has been created for implantation inside the portal vein in order to dole out insulin when needed. The pouch would ideally be "impregnated with insulin-producing pancreatic beta cells," but researchers have insinuated that this same system could possibly be used to treat other ailments such...
  • Diabetes Breakthrough(scientists cure disease in mice)

    12/15/2006 8:44:37 AM PST · by kellynla · 202 replies · 8,947+ views
    National Post ^ | Tom Blackwell,
    In a discovery that has stunned even those behind it, scientists at a Toronto hospital say they have proof the body's nervous system helps trigger diabetes, opening the door to a potential near-cure of the disease that affects millions of Canadians. Diabetic mice became healthy virtually overnight after researchers injected a substance to counteract the effect of malfunctioning pain neurons in the pancreas. "I couldn't believe it," said Dr. Michael Salter, a pain expert at the Hospital for Sick Children and one of the scientists. "Mice with diabetes suddenly didn't have diabetes any more." The researchers caution they have yet...
  • Good news for diabetics

    12/10/2006 4:43:28 AM PST · by sig226 · 4 replies · 389+ views
    Scientific American ^ | 11/12/06 | Philip E. Ross
    Putting Up with Self Critics warned of bad experiments and false hope. But Denise Faustman seems to be right about a strategy to regrow insulin-making cells killed off in diabetes By Philip E. Ross Five years ago Denise Faustman stunned the biomedical world--and not in a good way, it seemed. She declared that she had cured diabetic mice by getting them to regrow their insulin-producing beta cells, a finding that, if it could be translated to humans, would spare the million-odd Americans with type 1 diabetes their daily needle pricking and insulin dosing. Since her announcement, the academic establishment has...
  • Islet Cell Transplants Not Cure for Type 1 Diabetes Yet

    09/27/2006 6:06:01 PM PDT · by neverdem · 23 replies · 457+ views ^ | 09.27.06 | NA
    WEDNESDAY, Sept. 27 (HealthDay News) -- The latest study on islet cell transplantation has both good and bad news for people with type 1 diabetes. The good news is that nearly half of those who receive an islet cell transplant are insulin-free at one year after transplant; the bad news is that by the end of the second year that number drops to about one in seven. Still, researchers expect that with improvements in the technical aspects of the procedure, and better anti-rejection drugs, those numbers will improve. "A phenomenal amount of glycemic control can be provided with islet transplantation,"...
  • Update on Lead Diabetes Regenerative Therapy E1-I.N.T. Clinical Trials (DIABETIC FREEPERS)

    12/06/2005 12:15:46 PM PST · by Marie · 11 replies · 388+ views
    Transition Therapeutics Website ^ | Dec 5, 2005 | Transition Therapeutics
    TORONTO, Dec. 5 /CNW/ - Transition Therapeutics Inc. ("Transition")(TSX: TTH), announces an update on the ongoing exploratory Phase IIa clinical studies of its lead diabetes regenerative therapy, E1-I.N.T.™ for type I and type II diabetes patients as well as blinded safety and efficacy data for the type I diabetes clinical study. The main objective of these studies is to identify well-tolerated and safe doses of E1-I.N.T.™ in diabetes patients, and signs of efficacy by measuring parameters including insulin usage and HbA1c levels. Preliminary data from the first four type I diabetes patients completing the 4 week treatment period (E1-I.N.T.™ or...
  • Test will try to fend off type 1 diabetes

    11/25/2005 4:46:28 PM PST · by neverdem · 14 replies · 607+ views
    The Seattle Times ^ | November 24, 2005 | Warren King
    Seattle Times medical reporter Seattle researchers will soon begin testing a way to stave off diabetes by tripping up the immune system with the help of mouse cells. Scientists at the Pacific Northwest Research Institute (PNRI) will be part of a national effort to see if they can stop type 1 diabetes — or at least delay its progression — by derailing the immune cells that attack the body's insulin producers. The experimental therapy "has a reasonable shot at being the first building block toward a cure," said Dr. Bill Hagopian, director of PNRI's work on the therapy. In early...
  • Progress Seen in Transplants for Diabetes

    02/16/2005 8:36:27 PM PST · by neverdem · 16 replies · 482+ views
    NY Times ^ | February 16, 2005 | MARY DUENWALD
    Doctors may have found a way around a major obstacle in the effort to perfect transplants of islet cells, an experimental treatment for Type 1 diabetes, a severe form that often begins in childhood. Such transplants usually succeed only if islet cells from the pancreases of two or even three donors are used - a significant drawback, given the scarcity of donor organs. But now, in a trial of eight patients at the University of Minnesota, in Minneapolis, doctors have managed successful transplants of islet cells, which are needed to produce insulin, with the pancreases of single donors. The use...
  • Infant Cereal Linked To Diabetes?

    10/05/2003 11:31:27 AM PDT · by foolscap · 27 replies · 1,041+ views ^ | Oct. 2, 2003 | Emily Senay
    (CBS) There is new evidence that age matters when it comes to introducing cereal to the diet of a baby at risk from type 1 diabetes. Medical correspondent Dr. Emily Senay explains on The Early Show that those with type 1 diabetes have the misfortune of their immune system attacking and destroying the cells in the body that produce insulin. The medical community does not fully understand what causes it. But, Senay explains, a baby is at risk if there's a family history or genetic susceptibility. Two new studies in the latest Journal of the American Medical Association show a...
  • Cell therapy offers hope (Diabetes)

    03/11/2003 3:01:59 PM PST · by NormsRevenge · 1 replies · 246+ views
    SJ Mercury News ^ | 3/11/03 | Jamnie Talany - Newsday
    Since age 13, Ellen Berty has had to worry about having food in her pocket -- just in case she was stuck somewhere and her blood sugar levels were precariously off-balance. Diagnosed with Type 1 diabetes, Berty, 54, defied the odds of serious complications from diabetes until about three years ago. Without warning, she would fall into unconsciousness, her body suffering a severe hypoglycemic reaction. But the preschool educator from Arlington, Va., no longer worries about blackouts or emergency food supplies or, for that matter, the multiple daily injections of insulin that kept her alive for the past 40 years....