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Low Levels Of Good Cholesterol Linked To Memory Loss, Dementia Risk ScienceDaily (July 1, 2008) — Low levels of high-density lipoproteins (HDL) -- the "good" cholesterol -- in middle age may increase the risk of memory loss and lead to dementia later in life, researchers reported in Arteriosclerosis, Thrombosis and Vascular Biology: Journal of the American Heart Association. Observing 3,673 participants (26.8 percent women) from the Whitehall II study, researchers found that falling levels of HDL cholesterol were predictors of declining memory by age 60. Whitehall II, which began in 1985, is long-term health examination of more than 10,000 British...

Reversing a strategy that had drawn criticism from doctors, Pfizer says that it will apply for approval to sell a promising new heart treatment as a standalone pill — rather than only in combination with Lipitor, Pfizer’s best-selling cholesterol treatment. The new drug, torcetrapib, is still being tested in clinical trials and is at least 18 months from federal approval. But cardiologists say it has the potential to become a significant new treatment for heart disease. Clinical trials show that torcetrapib substantially raises the levels of so-called good cholesterol, a novel approach to preventing heart attacks and strokes. Wall Street...

In 1980, a man from a small town called Limone Sul Garda in northern Italy went to a doctor for some problem, not heart related. Testing of his blood showed very high levels of triglycerides, and very low levels of HDL, the good form of cholesterol. By all rights, the man should have either been dead from, or in imminent danger of a heart attack. But his arteries were clear. Analysis of his blood showed he had a very special form of Lipoprotein, a type of HDL. And further work with this particular type of Lipoprotein revealed astounding results. In...

NEW YORK (Reuters Health) - A relatively high amount of fat in the diet may be a boon to a healthy person's cholesterol levels, a small study suggests. On the other hand, limiting fat intake too much could have the opposite effect. Researchers at the State University of New York at Buffalo found that when 11 healthy but sedentary adults followed a very low-fat diet (19 percent of calories from fat) for three weeks, they saw a drop in their HDL cholesterol -- the "good" cholesterol believed to protect against heart disease. In contrast, three weeks on a diet that...

<p>The future of heart disease treatment is coming into focus with a growing emphasis on potent drug cocktails that fight obesity, help smokers quit, ease inflammation and restore a healthy blood-cholesterol balance.</p> <p>The shift may arrive in time for many aging baby boomers, doctors say, with several promising drugs undergoing pivotal tests in humans.</p>

An experimental drug can sharply increase levels of H.D.L., the good cholesterol, potentially offering an entirely new way to help prevent heart attacks, researchers have found. In a preliminary study, researchers at the University of Pennsylvania and Tufts University found that the drug doubled H.D.L., or high density lipoprotein, in people with worrisomely low levels of the cholesterol. The drug, called torcetrapib, also reduced low density lipoprotein, or L.D.L., the bad cholesterol. Until now, doctors have concentrated largely on lowering bad cholesterol by giving patients statin drugs, which are used by millions of Americans and reduce heart attacks by about...

For years, doctors have been saying that to prevent heart disease, patients should pay attention to both the so-called bad cholesterol, or L.D.L., and the good cholesterol, or H.D.L. The good, they said, can counteract the bad. But now, some scientists say, new and continuing studies have called into question whether high levels of the good cholesterol are always good and, when they are beneficial, how much. While some heart experts are not ready to change their treatment advice, others have concluded that H.D.L. should play at most a minor role in deciding whether to prescribe cholesterol-lowering drugs. In the...