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Keyword: alzheimersdisease

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  • Pat Bowlen resigns control of Denver Broncos, acknowledges he is dealing with Alzheimer's disease

    07/23/2014 6:24:19 AM PDT · by george76 · 11 replies
    ch 7 ^ | Jul 23, 2014 | Deb Stanley
    Denver Broncos team owner Pat Bowlen is steeping down from day-to-day operations because he is battling Alzheimer's Disease ... The Broncos said Bowlen had already been reducing his role in recent years while he was, "courageously and privately battling Alzheimer’s disease." "The Broncos are very saddened that Mr. Bowlen is no longer able to be part of the team’s daily operations due to his condition," the team said on its website. "We continue to offer our full support, compassion and respect to ‘Mr. B,’ who has faced Alzheimer’s disease with such dignity and strength." Team president Joe Ellis will assume...
  • Blood test that can predict Alzheimer's: Elderly could be given early warning

    03/09/2014 9:18:45 PM PDT · by neverdem · 32 replies
    Daily Mail (UK) ^ | 9 March 2014 | FIONA MACRAE
    The simple blood test could give early warning within three years The test could speed the search for new drugs that delay or prevent disease Experts are pleased, but it could bring health concerns if no cure is found A simple blood test has been developed that gives healthy elderly people precious early warning they may get Alzheimer’s within the next three years. It is hoped the test, the first to predict accurately who will become ill, could speed the search for new drugs that can delay or even prevent the devastating brain disease. It could eventually lead to widespread...
  • Former Reagan Spokesman Larry Speakes Dies at 74

    01/10/2014 4:13:03 PM PST · by EveningStar · 7 replies
    AP via ABC News ^ | January 10, 2014 | Emily Wagster Pettus
    Larry Speakes, who spent six years as acting press secretary for President Ronald Reagan, died Friday in his native Mississippi. He was 74. Speakes died at home in Cleveland, Miss., where he had lived the past several years. Bolivar County Coroner Nate Brown said Speakes had Alzheimer's disease.
  • Scientists pave way for simple pill to cure Alzheimer's

    10/09/2013 9:28:25 PM PDT · by neverdem · 29 replies
    Queensland Times ^ | 10th Oct 2013 | Charlie Cooper
    SCIENTISTS have hailed a historic "turning point" in the search for a medicine that could beat Alzheimer's disease, after a drug-like compound was used to halt brain cell death in mice for the first time. Although the prospect of a pill for Alzheimer's remains a long way off, the landmark British study provides a major new pathway for future drug treatments. The compound works by blocking a faulty signal in brains affected by neurodegenerative diseases. The signal shuts down the production of essential proteins, leading to brain cells being unprotected and dying off. The compound was tested in mice with...
  • The brain's GPS: Researchers discover human neurons linked to navigation in open environments

    08/06/2013 3:02:13 PM PDT · by neverdem · 9 replies
    Biology News Net ^ | August 5, 2013 | NA
    Using direct human brain recordings, a research team from Drexel University, the University of Pennsylvania, UCLA and Thomas Jefferson University has identified a new type of cell in the brain that helps people to keep track of their relative location while navigating an unfamiliar environment. The "grid cell," which derives its name from the triangular grid pattern in which the cell activates during navigation, is distinct among brain cells because its activation represents multiple spatial locations. This behavior is how grid cells allow the brain to keep track of navigational cues such as how far you are from a starting...
  • B-vitamins may delay Alzheimer’s onset

    05/24/2013 11:03:22 PM PDT · by neverdem · 17 replies
    Chemistry World ^ | 21 May 2013 | Emma Stoye
    UK researchers have found that high doses B-vitamins – including folic acid, vitamin B12 and vitamin B6 – can slow down brain tissue atrophy, a wasting process associated with Alzheimer’s disease.David Smith of the University of Oxford, and colleagues, used randomised controlled trials to test the long-term effects of B-vitamins on the brain health of elderly people with mild cognitive impairment, who were classed as having an increased risk of dementia. They found the brains of those treated with B-vitamins shrank less over a two year period than those given a placebo, and experienced less atrophy in regions of grey...
  • Pfizer and J&J end testing of intravenous bapineuzumab Alzheimer’s treatment

    08/08/2012 10:33:52 PM PDT · by neverdem · 15 replies
    Washington ^ | August 6, 2012 | Associated Press
    NEW YORK — Pfizer Inc. and Johnson & Johnson said Monday they are ending development of an intravenous formulation of a drug to treat Alzheimer’s disease after the treatment failed in two late-stage clinical trials. The companies said bapineuzumab intravenous did not work better than placebo in two late-stage trials in patients who had mild to moderate Alzheimer’s disease. The drug is designed to prevent the buildup of plaque in the brain. J&J said it is not discontinuing development of the compound and noted it has ongoing studies including a mid-stage neuroimaging study with bapineuzumab delivered subcutaneously...
  • Pelosi 'Swears' Spirit of Susan B. Anthony Spoke to Her in White House

    08/08/2012 8:48:29 PM PDT · by Justaham · 74 replies
    cnsnews.com ^ | 8/8/12 | Eric Scheiner
    House Minority Leader Nancy Pelosi (D.-Calif.) told a recent gathering of the Women’s Political Committee that the spirits of suffragists Susan B. Anthony, Elizabeth Cady Stanton and Alice Paul spoke to her at the White House. Pelosi said she heard them say: “At last we have a seat at the table”. A video recently posted on Youtube shows Pelosi speaking in May describing her first meeting with President Bush in the White House after becoming part of the Democratic House leadership.
  • Gene Mutation Protects Against Alzheimer's

    07/12/2012 11:00:14 AM PDT · by neverdem · 10 replies
    ScienceNOW ^ | 11 July 2012 | Greg Miller
    Enlarge Image Brain preserver. A newly discovered gene mutation appears to protect against Alzheimer's disease. Credit: Alzheimer's Disease Education and Referral Center/NIA/NIH A rare mutation that alters a single letter of the genetic code protects people from the memory-robbing dementia of Alzheimer's disease, according to a new study. The DNA change may inhibit the buildup of β amyloid, the protein fragment that accumulates in the hallmark plaques that form in the brains of Alzheimer's patients. Other researchers say the findings are intriguing but not hugely surprising. They fit well, in fact, with current thinking about Alzheimer's disease. The newly...
  • Robert Reno, brother of former U.S. Attorney General, dies (in lieu of flowers give to Obama)

    07/07/2012 11:14:40 PM PDT · by Cincinatus' Wife · 34 replies
    Miami Herald ^ | July 7, 2012 | ELINOR J. BRECHER
    Robert Maurius Reno, one of former U.S. Attorney General Janet Reno’s two younger brothers, died Saturday morning, according to their sister, Maggy Hurchalla, of Stuart. The Miami native was born Dec. 11, 1939, at Jackson Memorial Hospital and succumbed to Alzheimer’s disease at the Miami Veterans Administration Medical Center, where he’d been living for about four years. He was 74 and, said Hurchalla “a proud liberal Democrat.’’ Reno became a journalist, like his parents, the late Henry and Jane Reno, and spent most of his career at Newsday, the New York daily, starting as a reporter in 1968. As a...
  • F@H - Tale of the Tape!

    06/10/2012 9:00:28 PM PDT · by texas booster · 70 replies
    It has been a while since our last Free Republic Folding@Home update. The team has seen growth in the past couple of years as contributors have added high performance GPUs from NVidia and AMD/ATI, and same consoles such as the PS3. The team started in 2001 with a few volunteers, and grew dramatically in 2005 as we started actually posting regular threads. As we grew from a Top 2000 team to a Top 100 team, we attracted the attention of DU. After a couple of years of name calling, they realized that merely boasting that you can beat the opposition...
  • Alzheimer’s Vaccine Trial a Success

    06/09/2012 12:43:55 AM PDT · by neverdem · 26 replies
    ScienceDaily ^ | June 7, 2012 | NA
    A study led by Karolinska Institutet in Sweden reports for the first time the positive effects of an active vaccine against Alzheimer's disease. The new vaccine, CAD106, can prove a breakthrough in the search for a cure for this seriously debilitating dementia disease. The study is published in the scientific journal Lancet Neurology. Alzheimer's disease is a complex neurological dementia disease that is the cause of much human suffering and a great cost to society. According to the World Health Organisation, dementia is the fastest growing global health epidemic of our age. The prevailing hypothesis about its cause involves APP...
  • Alzheimer's disease - a neurospirochetosis.

    08/26/2011 1:12:38 PM PDT · by Swordmaker · 240 replies · 2+ views
    The Journal of NeuroInflamation ^ | August 4, 2011 | By Judith Miklossy, MD
    Alzheimer's disease - a neurospirochetosis. Analysis of the evidence following Koch's and Hill's criteria. Judith Miklossy Correspondence: Judith Miklossy judithmiklossy@bluewin.ch Journal of Neuroinflammation 2011, 8:90 doi:10.1186/1742-2094-8-90 Published: 4 August 2011 Abstract (provisional) It is established that chronic spirochetal infection can cause slowly progressive dementia, brain atrophy and amyloid deposition in late neurosyphilis. Recently it has been suggested that various types of spirochetes, in an analogous way to Treponema pallidum, could cause dementia and may be involved in the pathogenesis of Alzheimer's disease (AD). Here, we review all data available in the literature on the detection of spirochetes in AD and...
  • Alzheimer's blood test 'most accurate' so far

    08/09/2011 1:59:17 PM PDT · by neverdem · 5 replies
    Nature News ^ | 6 January 2011 | Ewen Callaway
    The blood of patients with the brain disease contains antibodies not found in healthy people. A new blood test diagnoses Alzheimer's disease by sensing molecules produced by the immune systems of people with the neurodegenerative condition. So far, the test has been applied to just a small number of blood samples, but if proven on a larger scale, the assay could help diagnose Alzheimer's disease in combination with other tests, says Thomas Kodadek, a professor of chemistry at the Scripps Research Institute in Jupiter, Florida. It could also be used to identify patients for trials of experimental Alzheimer's drugs, he...
  • Lessons about Alzheimer's disease

    08/09/2011 1:06:58 PM PDT · by neverdem · 47 replies
    Nature News ^ | 5 August 2011 | Gwyneth Dickey Zakaib
    Psychologist Margaret Gatz explains what 25 years of research have taught her about reducing the risk of dementia. Margaret Gatz, a psychologist at the University of Southern California, Los Angeles, is investigating the causes of Alzheimer's disease. To that end, she has studied the health of more than 14,000 Swedish twins for more than 25 years. On 5 August, she will tell the annual convention of the American Psychological Association in Washington DC what the study has taught her about how to reduce risk for the disease. Nature got a preview. What first motivated you to study Alzheimer's disease? Before...
  • Patterns: Treating Other Conditions May Stave Off Alzheimer’s, Study Finds

    04/19/2011 12:36:28 PM PDT · by neverdem · 5 replies
    NY Times ^ | April 15, 2011 | By RONI CARYN RABIN
    Older people suffering from mild memory and cognition problems may be less likely to progress to full-blown Alzheimer’s disease if they receive treatment for medical conditions like diabetes, high blood pressure and cholesterol, a new study has found. In 2004, researchers at Daping Hospital in Chongqing, China, began following 837 residents ages 55 and older who had mild cognitive impairment but not dementia. Of these, 414 had at least one medical condition that can impair blood flow to the brain. After five years, 298 of the participants had developed Alzheimer’s. Subjects who had had high blood pressure or other vascular...
  • Is Alzheimer's Disease Written in Blood?

    01/10/2011 3:26:31 PM PST · by neverdem · 4 replies
    ScienceNOW ^ | 6 January 2011 | Jennifer Couzin-Frankel
    Wherever it's buried in the body, a disease leaves traces in the blood—or so the thinking goes. But finding these biomarkers, which can help catch the disease early on, has been an exercise in futility, with one promising candidate after another losing its luster once it receives scrutiny. A team of chemists and other researchers now propose a new way to pick up biomarkers with a blood test: by screening for antibodies that the body makes in response to particular diseases. So far, the group has reported results for only a small number of Alzheimer's disease patients. But they are...
  • Blue-green algae tested for treating ALS (spirulina)

    12/21/2010 9:00:47 AM PST · by decimon · 7 replies
    University of South Florida (USF Health) ^ | December 21, 2010 | Unknown
    Ancient food source may offer neuroprotectionNutritional supplementation with Spirulina, a nutrient-rich, blue-green algae, appeared to provide neuroprotective support for dying motor neurons in a mouse model of amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, University of South Florida neuroscientists have found. Although more research is needed, they suggest that a spirulina-supplemented diet may provide clinical benefits for ALS patients. A spirulina dietary supplement was shown to delay the onset of motor symptoms and disease progression, reducing inflammatory markers and motor neuron death in a G93A mouse model of ALS. Spirulina, an ancient food source used by the...
  • 'Good' Cholesterol May Protect Against Alzheimer's

    12/13/2010 5:45:53 PM PST · by decimon · 21 replies
    Live Science ^ | December 13, 2010 | Rachael Rettner
    High levels of the so-called "good" cholesterol may lower the risk of developing Alzheimer's disease, according to a new study. In the study, those with high levels of high-density lipoprotein (HDL), the good kind of cholesterol, were 60 percent less likely to develop Alzheimer's disease than those with lower HDL levels. "The higher your HDL, the more protected you are from Alzheimer's disease, apparently," said study researcher Dr. Christiane Reitz, of Columbia University. The researchers found no evidence that high levels of "bad" cholesterol, known as low-density lipoprotein (LDL), affected a person's risk of Alzheimer's.
  • Insights Give Hope for New Attack on Alzheimer’s

    12/13/2010 11:48:12 PM PST · by neverdem · 49 replies · 3+ views
    NY Times ^ | December 13, 2010 | GINA KOLATA
    Alzheimer’s researchers are obsessed with a small, sticky protein fragment, beta amyloid, that clumps into barnaclelike balls in the brains of patients with this degenerative neurological disease. It is a normal protein. Everyone’s brain makes it. But the problem in Alzheimer’s is that it starts to accumulate into balls — plaques. The first sign the disease is developing — before there are any symptoms — is a buildup of amyloid. And for years, it seemed, the problem in Alzheimer’s was that brain cells were making too much of it. But now, a surprising new study has found that that view...
  • Scientists remove amyloid plaques from brains of live animals with Alzheimer's disease

    10/15/2009 7:52:05 AM PDT · by decimon · 24 replies · 951+ views
    New research in the FASEB Journal suggests that manipulation of the brain's own immune cells with IL-6 could lead to reversal of Alzheimer's disease pathologyA breakthrough discovery by scientists from the Mayo Clinic in Jacksonville, FL, may lead to a new treatment for Alzheimer's Disease that actually removes amyloid plaques—considered a hallmark of the disease—from patients' brains. This discovery, published online in The FASEB Journal (http://www.fasebj.org), is based on the unexpected finding that when the brain's immune cells (microglia) are activated by the interleukin-6 protein (IL-6), they actually remove plaques instead of causing them or making them worse. The research...
  • Positive And Negative Health Effects Of Caffeine

    06/29/2010 6:08:21 AM PDT · by GonzoII · 6 replies
    World Of Mysteries ^ | Sunday, June 27, 2010
    There is a good deal of debate about the health effects of caffeine, and whether these effects are primarily positive or negative. Caffeine, particularly in coffee, has been studied closely to determine where it may be of benefit, and where it may cause undesirable effects. Health benefits of caffeine Parkinson's disease Parkinson's is caused by the loss of brain cells that produce a chemical messenger called dopamine. According to a researcher from the Harvard School of Public Health in Boston, people who drink coffee or consume caffeine regularly have a lower risk of developing Parkinson's disease. The research put forth...
  • Alzheimer's memory problems originate with protein clumps floating in the brain, not amyloid plaques

    04/27/2010 1:21:52 PM PDT · by decimon · 10 replies · 546+ views
    Using a new mouse model of Alzheimer's disease, researchers at Mount Sinai School of Medicine have found that Alzheimer's pathology originates in Amyloid-Beta (Abeta) oligomers in the brain, rather than the amyloid plaques previously thought by many researchers to cause the disease. The study, which was supported by the "Oligomer Research Consortium" of the Cure Alzheimer Fund and a MERIT Award from the Veterans Administration, appears in the journal Annals of Neurology. "The buildup of amyloid plaques was described over 100 years ago and has received the bulk of the attention in Alzheimer's pathology," said lead author Sam Gandy, MD,...
  • Bacterial Product Isolated in Soil from Easter Island Rescues Learning, Memory in Alzheimer's...

    04/02/2010 1:18:10 PM PDT · by neverdem · 31 replies · 996+ views
    ScienceDaily ^ | Mar. 8, 2010 | NA
    Bacterial Product Isolated in Soil from Easter Island Rescues Learning, Memory in Alzheimer's Mouse Model Rapamycin, a drug that keeps the immune system from attacking transplanted organs, may have another exciting use: fighting Alzheimer's disease. The drug -- a bacterial product first isolated in soil from Easter Island -- rescued learning and memory deficits in a mouse model of Alzheimer's, a team from The University of Texas Health Science Center at San Antonio reported on Feb. 23. The study, in the Journal of Biological Chemistry, offers the first evidence that the drug is able to reverse Alzheimer's-like deficits in an...
  • New test takes guesswork out of diagnosing early-stage Alzheimer's disease

    03/25/2010 11:26:12 AM PDT · by decimon · 4 replies · 221+ views
    New research in the FASEB Journal reports that a novel enzyme-linked immunosorbent assay could be a critical diagnostic tool for the detection of A-Beta oligomers, proteins which cause Alzheimer’s diseaseA new test developed by Japanese scientists may revolutionize how and when physicians diagnose Alzheimer's disease. According to a research report published online in The FASEB Journal (http://www.fasebj.org), the new test measures proteins in the spinal fluid known to be one of the main causes of brain degeneration and memory impairment in Alzheimer's patients: high molecular weight A-Beta oligomers. This tool, once fully implemented, would allow physicians to diagnose and treat...
  • Hopes for Alzheimer’s Drug Are Dashed

    03/10/2010 3:03:00 PM PST · by neverdem · 3 replies · 249+ views
    NY Times via Gainesville Sun ^ | March 4, 2010 | ANDREW POLLACK
    It seemed somewhat unlikely, but in recent years an old Russian hay fever pill had become one of the world’s best hopes for treating the growing epidemic of Alzheimer’s disease. But those hopes were dashed on Wednesday when the drug failed in its first late-stage clinical trial, dealing a blow not only to patients with Alzheimer’s and their families but to the companies developing the treatment — a start-up in San Francisco called Medivation and the world’s largest drug company, Pfizer. The companies said in a statement that the drug, called Dimebon, had shown virtually no effect after six months...
  • Infection Defense May Spur Alzheimer’s

    03/09/2010 3:06:00 PM PST · by neverdem · 14 replies · 448+ views
    NY Times ^ | March 8, 2010 | GINA KOLATA
    For years, a prevailing theory has been that one of the chief villains in Alzheimer’s disease has no real function other than as a waste product that the brain never properly disposed of. The material, a protein called beta amyloid, or A-beta, piles up into tough plaques that destroy signals between nerves. When that happens, people lose their memory, their personality changes and they stop recognizing friends and family. But now researchers at Harvard suggest that the protein has a real and unexpected function — it may be part of the brain’s normal defenses against invading bacteria and other microbes....
  • New Israeli Research: How To Boost Memory and Avoid Memory Loss

    02/23/2010 2:19:14 AM PST · by Baruchg · 19 replies · 938+ views
    Israel National News ^ | February 23, 2010 | Baruch Gordon
    Those who live in industrialized countries have easy access to healthy food and nutritional supplements, but magnesium deficiencies are still common. That's a problem because new research from Tel Aviv University suggests that magnesium, a key nutrient for the functioning of memory, may be even more critical than previously thought for the neurons of children and healthy brain cells in adults. Dr. Inna Slutsky of TAU's Sackler School of Medicine published results of a 5-year probe which has significant implications for the use of over-the-counter magnesium supplements.
  • Easy amyloid refolding

    02/20/2010 10:54:33 AM PST · by neverdem · 14 replies · 453+ views
    Highlights in Chemical Biology ^ | 19 February 2010 | Frances Galvin
    Spontaneous refolding of amyloid fibres under mild conditions could provide insight into Alzheimer's disease claim scientists in the US. Amyloids are collections of twisted or misfolded proteins and often develop in the brains of people with a number of neurodegenerative diseases, including Alzheimer's and Parkinson's. They have been considered to be the most thermodynamically stable form of protein as very harsh conditions are required to disrupt them. But Igor Lednev and his team at the University of Albany have found amyloid fibres change from one polymorph to another with just mild changes in solution temperature and salinity. Lednev hopes this discovery will provide insight...
  • Eye test that spots Alzheimer's 20 years before symptoms: Middle-aged could be screened at...

    01/14/2010 9:27:15 PM PST · by neverdem · 8 replies · 866+ views
    dailymail.co.uk ^ | 15th January 2010 | Fiona Macrae
    Middle-aged could be screened at routine optician's visit A test that can detect Alzheimer's up to 20 years before any symptoms show is being developed by British scientists. The simple and inexpensive eye test could be part of routine examinations by high street opticians in as little as three years, allowing those in middle age to be screened. Dementia experts said it had the power to revolutionise the treatment of Alzheimer's by making it possible for drugs to be given in the earliest stages. The technique, being pioneered at University College London, could also speed up the development of medication...
  • Green tea chemical combined with another may hold promise for treatment of brain disorders

    12/03/2009 6:40:20 AM PST · by decimon · 13 replies · 774+ views
    Watertown, MA—Scientists at Boston Biomedical Research Institute (BBRI) and the University of Pennsylvania have found that combining two chemicals, one of which is the green tea component EGCG, can prevent and destroy a variety of protein structures known as amyloids. Amyloids are the primary culprits in fatal brain disorders such as Alzheimer's, Huntington's, and Parkinson's diseases. Their study, published in the current issue of Nature Chemical Biology (December 2009), may ultimately contribute to future therapies for these diseases. "These findings are significant because it is the first time a combination of specific chemicals has successfully destroyed diverse forms of amyloids...
  • Can you catch Alzheimer's Disease?

    10/28/2009 1:37:17 PM PDT · by hennie pennie · 23 replies · 965+ views
    The Dallas Disability Examiner ^ | October 26, 2009 | Steve Carter
    Alzheimer's caused by cold sore virus? In a connection that sounds borderline preposterous, links have been accumulating between Alzheimer's disease and cold sores....Cold sores are caused by the herpes simplex virus type 1, a type that should not be confused with herpes symplex virus type 2 which is the cause of genital herpes. A growing body of research, suggests that the HSV-1 may also be responsible for the majority of Alzheimer's cases.... "There's clearly a very strong connection," says British researcher, Ruth Itzhaki, Ph.D., speaking one afternoon in her office at the University of Manchester, in northwestern England. A neurobiologist,...
  • Caffeine reverses memory impairment in Alzheimer's mice

    07/06/2009 2:01:05 PM PDT · by ConservativeMind · 19 replies · 997+ views
    Physorg.com ^ | July 7, 2009 | University of South Florida Health
    Enlarge Caffeine treatment removed the beta amyloid plaques from the brains of the Alzheimer's mice. Credit: Photo courtesy of Florida Alzheimer's Disease Research Center Coffee drinkers may have another reason to pour that extra cup. When aged mice bred to develop symptoms of Alzheimer's disease were given caffeine - the equivalent of five cups of coffee a day - their memory impairment was reversed, report University of South Florida researchers at the Florida Alzheimer's Disease Research Center. Back-to-back studies published online today in the Journal of Alzheimer's Disease, show caffeine significantly decreased abnormal levels of the protein linked to...
  • Caffeine May Prevent and Help Reverse Alzheimer's Disease

    08/02/2009 6:31:50 PM PDT · by SmartInsight · 30 replies · 1,201+ views
    Natural News ^ | Aug. 2, 2009 | S. L. Baker
    In experiments with lab mice especially bred to develop symptoms of Alzheimer's disease, University of South Florida (USF) researchers at the Florida Alzheimer's Disease Research Center ADRC gave the aged animals the equivalent of the caffeine in five cups of coffee a day. The results? Their severe memory impairment was reversed. This study, along with other AD research by the same group of scientists, was just published in the Journal of Alzheimer's Disease. Both studies show that caffeine significantly decreased abnormal levels of beta amyloid (the protein linked to AD) in both the brains and blood of lab rodents who...
  • Drinking coffee reduces risk of Alzheimer's: study

    01/16/2009 9:46:11 AM PST · by Schnucki · 55 replies · 1,452+ views
    AFP ^ | January 15, 2008
    STOCKHOLM — Middle-aged people who drink moderate amounts of coffee significantly reduce their risk of developing Alzheimer's disease, a study by Finnish and Swedish researchers showed Thursday. "Middle-aged people who drank between three and five cups of coffee a day lowered their risk of developing dementia and Alzheimer's disease by between 60 and 65 percent later in life," said lead researcher on the project, Miia Kivipelto, a professor at the University of Kuopio in Finland and at the Karolinska Institute in Stockholm. The study, which was also conducted in cooperation with the National Public Health Institute in Helsinki and which...
  • Tracing amyloid in Alzheimer's

    10/15/2009 12:40:26 AM PDT · by neverdem · 26 replies · 1,414+ views
    Chemistry World ^ | 14 October 2009 | Phil Taylor
    A diagnostic compound that allows researchers to look into the brains of Alzheimer's patients will be used for the first time to gauge the effects of an experimental therapy for the disease. Called florbetaben, the diagnostic could also provide important insights into the role of beta amyloid, a protein that accumulates into plaques in the brains of patients with Alzheimer's disease and has been shown to be toxic to nerve cells. The compound is an 18F-radiolabelled tracer that binds specifically to deposits of beta amyloid, and can be measured using positron emission tomography (PET), a nuclear imaging technique which produces a three-dimensional image of...
  • A Connection Between Sleep and Alzheimer's?

    09/25/2009 6:26:22 PM PDT · by neverdem · 18 replies · 1,349+ views
    ScienceNOW Daily News ^ | 24 September 2009 | Greg Miller
    You shouldn't stay up all night worrying about it, but a new study has found a connection between a lack of sleep and a biomolecule thought to be important in the development of Alzheimer's disease. In both humans and mice, levels of a peptide called amyloid-β rise during waking hours and decline during sleep, researchers have found. They also report that sleep-deprived mice are more prone to developing deposits of amyloid-β, called plaques, like those found in the brains of Alzheimer's patients. Although far from proven, the finding suggests that sleep disorders could be a risk factor for Alzheimer's. On...
  • At the Bridge Table, Clues to a Lucid Old Age

    05/22/2009 8:06:24 PM PDT · by JoeProBono · 13 replies · 883+ views
    times. ^ | May 21, 2009 | BENEDICT CAREY
    LAGUNA WOODS, Calif. — The ladies in the card room are playing bridge, and at their age the game is no hobby. It is a way of life, a daily comfort and challenge, the last communal campfire before all goes dark. “We play for blood,” says Ruth Cummins, 92, before taking a sip of Red Bull at a recent game. “It’s what keeps us going,” adds Georgia Scott, 99. “It’s where our closest friends are.” In recent years scientists have become intensely interested in what could be called a super memory club — the fewer than one in 200 of...
  • News From The American Chemical Society, May 13, 2009

    06/13/2009 11:53:42 AM PDT · by neverdem · 5 replies · 632+ views
    News From The American Chemical Society, May 13, 200919 May 2009    Advance in detecting melamine-adulterated food Researchers in Indiana are reporting an advance toward faster, more sensitive tests for detecting melamine, the substance that killed at least 6 children and sickened 300,000 children in China who drank milk and infant formula adulterated with the substance. The improved tests may ease global concerns about food safety, the researchers say. Their report is scheduled for the May 27 issue of ACS' Journal of Agricultural and Food Chemistry, a bi-weekly publication. In the new study, Lisa Mauer and colleagues note that tests...
  • Attacking Alzheimer's disease

    05/27/2009 11:12:54 PM PDT · by neverdem · 9 replies · 631+ views
    Royal Society of Chemistry ^ | 06 May 2009 | Laura Howes
    Canadian scientists have been inspired by analytical chemistry to attack Alzheimer's disease from all sides. Chris Orvig from the University of British Columbia, Vancouver, and colleagues made multifunctional compounds to target amyloid plaque formation, a possible cause of Alzheimer's disease. Amyloid plaques are protein clusters with metal ions that accumulate between neurons in Alzheimer's patients' brains. Orvig designed his compounds to combat the protein misfolding and metal-peptide interactions involved in amyloid plaque production as well as the oxidative stress that occurs (a condition that damages cells, caused by excess free radicals). 'We aren't 100 per cent sure about the order...
  • A good egg

    05/27/2009 10:35:49 PM PDT · by neverdem · 6 replies · 765+ views
    Royal Society of Chemistry ^ | 27 May 2009 | Anna Roffey
    UK and Dutch scientists have mimicked an ancient Chinese culinary technique of preserving eggs to study how proteins cause disease. Erika Eiser from the University of Cambridge and colleagues looked at how proteins in egg whites altered during this preservation process. The Chinese method involves wrapping raw eggs in an alkaline paste of lime, clay, salt, ash and tea and storing these so-called century eggs for several months. Eiser modified the method by incubating a boiled egg in a strong alkaline sodium hydroxide-salt solution for up to 26 days. Hard boiled egg whites become a transparent gel in an alkaline...
  • 'Harmless' prion protein linked to Alzheimer's disease

    02/27/2009 9:42:29 PM PST · by neverdem · 17 replies · 1,512+ views
    Nature News ^ | 25 February 2009 | Heidi Ledford
    Non-infectious form of prion protein could cause brain degeneration. Prion proteins may react with amyloid-(beta) peptides inside the brain cells of Alzheimer's patients.Thomas Deerinck NCMIR/Science Photo Library Non-infectious prion proteins found in the brain may contribute to Alzheimer's disease, researchers have found. The surprising new results, reported this week in Nature1, show that normal prion proteins produced naturally in the brain interact with the amyloid-(beta) peptides that are hallmarks of Alzheimer's disease. Blocking this interaction in preparations made from mouse brains halted some neurological defects caused by the accumulation of amyloid-(beta) peptide. It was previously thought that only infectious prion...
  • Eat Less, Remember More?

    01/29/2009 12:37:00 AM PST · by neverdem · 28 replies · 1,340+ views
    ScienceNOW Daily News ^ | 27 January 2009 | Rachel Zelkowitz
    Did Grandma seem forgetful at the holiday parties last month? It could be time to put her on a diet. Sharply reducing calories improves memory in older adults, according to one of the first studies of dietary restriction and cognitive function in humans. Research on the benefits of an extremely low-calorie diet stretches back to the 1930s, when scientists found that rats lived up to twice as long when they nibbled less than control animals. Since then, some studies with rodents and nonhuman primates have shown that this spare diet, known as calorie restriction, improves some markers of diabetes and...
  • Old gastrointestinal drug slows aging, McGill researchers say

    01/06/2009 3:20:16 PM PST · by decimon · 22 replies · 1,248+ views
    McGill University ^ | Jan. 6, 2008 | Unknown
    Clioquinol inhibits action of the CLK1 aging gene, may alleviate Alzheimer'sRecent animal studies have shown that clioquinol – an 80-year old drug once used to treat diarrhea and other gastrointestinal disorders – can reverse the progression of Alzheimer's, Parkinson's and Huntington's diseases. Scientists, however, had a variety of theories to attempt to explain how a single compound could have such similar effects on three unrelated neurodegenerative disorders. Researchers at McGill University have discovered a dramatic possible new answer: According to Dr. Siegfried Hekimi and colleagues at McGill's Department of Biology, clioquinol acts directly on a protein called CLK-1, often informally...
  • Vitamin B3 reverses Alzheimers in mice (and probably humans)

    12/10/2008 8:09:07 AM PST · by djf · 22 replies · 1,734+ views
    NPR ^ | Nov 7, 2008 | multiple
    Talk of the Nation, November 7, 2008 · A new study published in the Journal of Neuroscience shows that mice treated with large doses of vitamin B3 performed better on memory tests. Kim Green, one of the authors of the study, explains whether this discovery could have any application for treating Alzheimer's in humans.
  • Folding@Home - Published Research on Alzheimer's Disease

    12/08/2008 12:10:04 PM PST · by texas booster · 44 replies · 2,410+ views
    Journal of Chemical Physics ^ | December 4 2008 | Vijay Pande
    ... We present a novel computational approach for describing the formation of oligomeric assemblies at experimental concentrations and timescales. We propose an extension to the Markovian state model approach, where one includes low concentration oligomeric states analytically. This allows simulation on long timescales (seconds timescale) and at arbitrarily low concentrations (e.g., the micromolar concentrations found in experiments), while still using an all-atom model for protein and solvent. As a proof of concept, we apply this methodology to the oligomerization of an Abeta peptide fragment (Abeta 21–43). Abeta oligomers are now widely recognized as the primary neurotoxic structures leading to Alzheimer's...
  • Gene Variant May Contribute to Alzheimer's Disease HealthDay Reporter

    06/25/2008 10:40:02 PM PDT · by neverdem · 1 replies · 184+ views
    HealthDay News ^ | June 25, 2008 | Randy Dotinga
    The finding could open the door to improved treatments. Researchers say they've discovered a gene that may make it easier for people to develop Alzheimer's disease, and it could become a target for drug treatments. "This new work not only provides a better understanding of the mechanism leading to the disease, but identifies a risk factor as an important target for therapy," said Philippe Marambaud, an assistant professor of pathology at the Albert Einstein College of Medicine in New York City and member of an international team of scientists that released its findings Wednesday. Alzheimer's disease, which causes senility and...
  • Doctors Say Medication Is Overused in Dementia

    06/24/2008 7:25:12 PM PDT · by neverdem · 19 replies · 119+ views
    NY Times ^ | June 24, 2008 | LAURIE TARKAN
    Ramona Lamascola thought she was losing her 88-year-old mother to dementia. Instead, she was losing her to overmedication. Last fall her mother, Theresa Lamascola, of the Bronx, suffering from anxiety and confusion, was put on the antipsychotic drug Risperdal. When she had trouble walking, her daughter took her to another doctor — the younger Ms. Lamascola’s own physician — who found that she had unrecognized hypothyroidism, a disorder that can contribute to dementia. Theresa Lamascola was moved to a nursing home to get these problems under control. But things only got worse. “My mother was screaming and out of it,...
  • Advance Towards Early Alzheimer's Diagnosis

    06/22/2008 3:46:59 PM PDT · by neverdem · 36 replies · 261+ views
    Medical News Today ^ | 20 Jun 2008 | NA
    The leader of the team that made the discovery, Professor Christopher Rowe of the Austin Hospital in Melbourne, says early diagnosis and treatment presents medical practitioners with the best opportunity to delay the onset of Alzheimer's. "While the discovery is at an experimental stage, this work places Australia at the forefront of neuro-imaging in Alzheimer's disease," Professor Rowe says. A 2004 Access Economics report calculated that if the average age of onset of Alzheimer's was raised by just five months, cumulative savings of A$1.3 billion would be realised by 2020 rising to A$6.6 billion by 2040. Alzheimer's disease is characterised...
  • Euthanasia Provider to Alzheimer's Patients: The Best Remedy is Death

    06/20/2008 4:17:03 PM PDT · by wagglebee · 38 replies · 391+ views
    LifeSiteNews ^ | 6/20/08 | Tim Waggoner
    SYDNEY, June 20, 2008 (LifeSiteNews.com) - Euthanasia provider and activist Dr. Philip Nitschke has released controversial statements that essentially instruct anyone who believes they are suffering from Alzheimer's disease to avoid obtaining a diagnosis in favour of seeking a doctor who can help them commit suicide as quickly as possible. These comments come on the heels of yesterday's New South Wales jury ruling that convicted two women for the "euthanasia" death of a 71-year old Sydney man, Graeme Wylie, in 2006. As reported by the news service, The Age, Shirley Justins, the wife of Wylie, was convicted of manslaughter for...