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Cholesterol drug cuts heart risks, spurs new debate on cost
The Seattle PI ^ | Sunday, March 19, 2017 | Cholesterol drug cuts heart risks, spurs new debate on cost Marilynn Marchione

Posted on 03/19/2017 8:30:36 PM PDT by steve86

Repatha cut by 20 percent the combined risk of having either a heart attack, stroke or a heart-related death. That happened to nearly 6 percent of people on Repatha versus more than 7 percent on the dummy drug. The benefit grew with longer use, and was 25 percent the second year, said Sabatine, who consults for Amgen and other drugmakers.

The drug cut by 15 percent a broader set of problems — the ones above plus hospitalization for chest pain or an artery-opening procedure. Nearly 10 percent of folks on Repatha had one versus more than 11 percent on the dummy drug

(Excerpt) Read more at seattlepi.com ...


TOPICS: Business/Economy; Culture/Society; News/Current Events
KEYWORDS: newclasslipiddrug; statin
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To: steve86

This is nothing like a statin. This is actually an antibody that targets the enzyme that degrades the protein that binds LDL to the liver cells. That results in more of this binding protein which in turn binds more LDL so the liver can take it out of circulation. It’s an interesting idea, and is especially promising for people who have a genetic predilection for high LDL.


21 posted on 03/19/2017 9:37:06 PM PDT by VanShuyten ("...that all the donkeys were dead. I know nothing as to the fate of the less valuable animals.")
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To: LesbianThespianGymnasticMidget

On atorvastatin since my quadruple bypass three years ago. Total cholesterol is around 110. Metoprolol keeps my heart rate in 50’s. Lisinopril helps keep my BP normal. Diet and exercise are biggest changes I’ve made.


22 posted on 03/19/2017 11:08:09 PM PDT by OrioleFan (Republicans believe every day is July 4th, Democrats believe every day is April 15th.)
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To: Terry Mross

bbb. Will check back next week


23 posted on 03/19/2017 11:26:17 PM PDT by thinden
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To: CyberAnt

Is it a capsule? Can you get the same effect by drinking earl grey tea?


24 posted on 03/20/2017 12:08:28 AM PDT by kalee
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To: be-baw
“ I ask because my cardiologist wants to double my Crestor dosage.”

You might want to check with the FDA

There have been rare post-marketing reports of cognitive impairment (such as memory loss, forgetfulness, amnesia, memory impairment, and confusion) associated with statin use.

more at https://www.fda.gov/Drugs/DrugSafety/DrugSafetyPodcasts/ucm294367.htm

and

Statins are typically very well tolerated. Two risks that patients may be aware of are muscle-related complaints and an increased risk of developing type 2 diabetes

more at https://www.fda.gov/ForConsumers/ConsumerUpdates/ucm293330.htm

81 page PDF from 201 here: https://www.lipid.org/sites/default/files/articles/statinsafety2014update.pdf

25 posted on 03/20/2017 1:20:34 AM PDT by spokeshave (In the Thatch Weave,..Trump's Wing Man is Truth)
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To: steve86

Cholesterol levels and heart attacks is a BS scam to begin with and the side effects of statins is far worse.


26 posted on 03/20/2017 2:09:12 AM PDT by maddog55 (America Rising)
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To: steve86

“Repatha cut by 20 percent the combined risk of having either a heart attack, stroke or a heart-related death. That happened to nearly 6 percent of people on Repatha versus more than 7 percent on the dummy drug.”

In other words, statitical noise elevated to medical benefit by snakeoil salesmen.


27 posted on 03/20/2017 2:37:51 AM PDT by miniTAX
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To: lepton

agreed - big pharma is a racket

my doc prescribed some statins 15 years ago. I nicely told him I ignore his reccomendation.

latest blood work

LDH -125
HDH - 45

real food and physical activity beat drugs -always


28 posted on 03/20/2017 3:04:56 AM PDT by vooch
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To: steve86

Well they can keep it. I looked it up, it hits 8 areas that always trigger drug side effects. Always look up meds for side effects. I have 5 Gastro issues, you think I want to add more to that? NO WAY!

http://www.rxlist.com/repatha-side-effects-drug-center.htm

What they need to work on is how to raise HDL especially for men, as that is the big problem. Hubby is lucky to hit 41, I hit 85. Which negates a lot of the other 2.


29 posted on 03/20/2017 4:41:08 AM PDT by GailA (Ret. SCPO wife: suck it up Buttercups it's President Donald Trump! DRAIN THE SWAMP)
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To: Terry Mross

Have you looked into K2 complex as your blood thinner, it actually dissolves the plaque in your arteries. And keeps the Calcium in your bones. I had to find a natural way to thin blood, as even a baby aspirin will set off the gastro problems. Only K2 Complex dissolves the plaque.


30 posted on 03/20/2017 4:45:52 AM PDT by GailA (Ret. SCPO wife: suck it up Buttercups it's President Donald Trump! DRAIN THE SWAMP)
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To: steve86

Small benefit demonstrated with small sample size. Statistical noise.

Looks like the typical shell game.


31 posted on 03/20/2017 4:59:07 AM PDT by UnwashedPeasant (I told you so)
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To: steve86

7% on the dummy drug and 6% on the new drug

What a joke


32 posted on 03/20/2017 5:05:47 AM PDT by uncbob
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To: CyberAnt

Bkmk


33 posted on 03/20/2017 5:35:07 AM PDT by Ignatz (Winner of a prestigious 1960 Y-chromosome award!)
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To: steve86

It’s an injection? No thank you.


34 posted on 03/20/2017 5:37:27 AM PDT by McGruff (#PlugTheLeaks)
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To: bravo whiskey

Red rice yeast is a statin.

” My HDL is crazy high too which elevates my total. “

Lowers your total


35 posted on 03/20/2017 5:39:07 AM PDT by AppyPappy (Don't mistake your dorm political discussions with the desires of the nation)
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To: spokeshave

“There have been rare post-marketing reports of cognitive impairment (such as memory loss, forgetfulness, amnesia, memory impairment, and confusion) associated with statin use.”

I was on statins and thought I was becomming senile.

Got off of them because of the muscle pain and my mental issues have cleared up.


36 posted on 03/20/2017 5:44:47 AM PDT by Gadsden1st
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To: Scram1

It’s the inflammation that gets you. If cholesterol is bad, why does the body make so much of it?


37 posted on 03/20/2017 5:55:29 AM PDT by Poison Pill
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To: lepton

A 20 percent cut in 6 percent of people taking it.. I agree, it’s placebo or random error rate. How about patient with a multi-generations history of cardiac related mortality? Sensationalized statistics to give people the false hope they will have this very minute outcome.


38 posted on 03/20/2017 6:44:21 AM PDT by momincombatboots (pathway to citizenship... Amnesty history repeats. Walling Illegals In wasn't the idea moron!)
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To: Gadsden1st
I was on statins and thought I was becomming senile.

Ha...you were lucky....i thought i had adzheimers

was 15 years ago...anyway...at one point I read the label and noticed the warning about muscle loss....so i stopped taking the statins....and slowly got better>

I passed the physical for truck drivers license at age 71...drove interstate for 2 years...and 6 months driving delivering propane.....the delivery hose is 150 ft long and weighs 1.75 lb per foot...it's necessary to pull the entire hose out and check for leaks every week...when i started could only pull about 30 ft out without stopping....by the time i quit could pull the entire 150 ft hose off the reel on gravel road without stopping.

now i control cholesterol, glucoese and BP with heavy weight lifting...just passed 365lb leg press...which might explain why i busted the clutch linkage on my 78 ford F100 truck twice. (its all manual)...not too shabby at age 75....now i drive part time for uber.

39 posted on 03/20/2017 6:49:45 AM PDT by spokeshave (In the Thatch Weave,..Trump's Wing Man is Truth)
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To: be-baw

Sounds like your primary is more informed...I’m told by Dr. Jonathan Wright, Tahoma Clinic, that it’s the RATIOS that matter, not the totals. You may want to do a little more research.


40 posted on 03/20/2017 6:51:03 AM PDT by goodnesswins (Say hello to President Trump)
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