Alcohol used to be MUCH more prevalent than it is today. There are records of rail road workers being paid in alcohol. Many "medicines" were nothing more than flavored alcohol.
We have been "drugging" ourselves for a loooong time.
I am not in favor of legalizing marijuana, but I do think it should be a state by state issue.
Having been born in Oklahoma I remember when the state was dry, lot of interstate commerce resulted from that. I also remember when Missouri had Blue Laws.