Obesity is Inflammatory Disease, Rat Study Shows

Sci-News ^ | 2013 December 05 | Sci-News

[CutePuppy]

Scientists led by Dr David Fairlie from the University of Queensland, Australia, have found abnormal amounts of an inflammatory protein called PAR2 in the fat tissues of overweight and obese rats and humans. PAR2 is also increased on the surfaces of human immune cells by common fatty acids in the diet. When obese rats on a diet high in sugar and fat were given a new oral drug that binds to PAR2, the inflammation-causing properties of this protein were blocked, as were other effects of the high-fat and high-sugar diet, including obesity itself.

"This important new finding links obesity and high fat, high sugar diets with changes in immune cells and inflammatory status, highlighting an emerging realization that obesity is an inflammatory disease," Dr Fairlie said. ..... < snip >

..... To make the discovery, the team discovered the first potent, selective and orally bioavailable small molecule antagonists of PAR2 and characterized their functional responses in inflammatory cellular and animal models.

They found that PAR2 expression is increased in vivo in adipose tissue from obese humans and rats, stimulated in vitro in human macrophages by the dietary fatty acid palmitic acid, and inhibited in vivo and in vitro by a PAR2 antagonist. This antagonist was then used as a tool to dissect roles for PAR2 activation in mediating metabolic dysfunction in human monocyte-derived macrophages (HMDM), human and rodent adipocytes, and diet-induced obesity in rats.

Oral treatment of diet-induced obese rats attenuated PAR2 signaling in adipose tissue and inhibited adipose inflammation, insulin resistance, diet-induced obesity and cardiovascular abnormalities.

This is the first report that a PAR2 antagonist improves obesity, glucose homeostasis and obesity-associated chronic inflammation in vivo. ..... < snip >

[goodnesswins]

If you’re obese..you’re likely eating the WRONG FOOD

[mouske]

“Crohns, RA, IBD, IBS and a number of other inflammatory and/or autoimmune diseases.”

...and probably ankylosing spondylitis (hoping).

[Jeff Chandler]

maybe the nicotine kept everybody slim?

I've heard that.

[fr_freak]

If it was sedentary lifestyles and plentiful food alone that caused the obesity epidemic, then it should have taken off in the 1950's.

My guess is not the abundance of food, so much as the nature of food now vs. 1950s. Now it is all processed crap. Few people actually cook real meals from raw food anymore.

[Gene Eric]

Or Atkins, or South Beach...

[Gene Eric]

>> the WRONG FOOD

Is crap considered food?

[Chickensoup]

Of course darn near everyone smoked, maybe the nicotine kept everybody slim?

______________

Cigarettes were the number one cause of slimness. Everyone got fat after ciggies were banned from polite society..

[RoosterRedux]

Yep. Fat just drops off.

That's how body builders get cut.

[RoosterRedux]

Back in the '50's, my dad worked in the garden every day for an hour or two. And my skinny mom cleaned the house and cooked.

Nowadays, every one does nothing...hence the blubber butt.

Of course Obama smokes a little crack with his pies...and then he and Reggie get some exercise (if you know what he means).

Hence, Obama got the "slims."

[ottbmare]

I am fat and swollen
stoopid prednasone
stoopid ben and jerrys
stoopid repeated surgeries each 4 years!

Prednisone alters carbohydrate metabolism as well as increasing appetite. The only way you can avoid gaining weight while you're on steroids is to stop eating junk carbs. Confine your carbohydrate intake to a few green vegetables. Eat protein--fish, poultry, meat. Eat good fats like olive oil, coconut oil, butter from grass-fed beef. No rice, potatoes, sugar, pasta, bread; certainly no sugar ever. You will lose water as well as fat.

[Bigg Red]

And if you can’t construct a proper sentence, you are functionally illiterate.

[Bigg Red]

maybe the nicotine kept everybody slim?

&&
I’ve heard that.

&&&
The children were not smoking!

[Ken H]

Is crap considered food?

When it's between two pieces bread, it's called forced feeding:)

[mlo]

"if your obese, you eat too much, it’s that simple."

But it's not that simple. That's the point.

[Smokin' Joe]

&&& The children were not smoking!

One of the benefits of 'second hand smoke'? (If not, the kids went outside and did something to get out of the smoke and got some exercise!)

[MediaMole]

The right kind of carbs are OK. Veggies, sweet potatoes, some regular potatoes, even rice. Avoid the quick sugar rush carbs and you will be OK.

[informavoracious]

There were lots of white collar dads who sat at a desk all day! Labor saving devices were readily available to women! We sprinkled sugar on our corn flakes, ate white bread, mashed potatoes, white rice, fatty pork chops covered in greasy gravy, fried chicken, butter-drenched vegetables, cake with sugary icing and full-fat ice cream and no one was fat.

[CutePuppy]

We sprinkled sugar on our corn flakes, ate white bread, mashed potatoes, white rice, fatty pork chops covered in greasy gravy, fried chicken, butter-drenched vegetables, cake with sugary icing and full-fat ice cream and no one was fat.

:~)

That so reminded me of the scene from the movie Cocoon (1985): "When we get where we're going, we'll never be sick, we won't get any older, and we won't ever die."

[wontbackdown]

Good idea, thanks. I also drink dry red wine about twice per week.

[Bigg Red]

Well, I guess, considering your handle, you want to go with the hypothesis that nicotine keeps you slim. :)