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CRISPR creates new species with single giant chromosome
MIT Technology Review ^ | 08/01/2018 | Antonio Regalado

Posted on 08/01/2018 5:09:32 PM PDT by aimhigh

For at least the last 10 million years every yeast cell of the sort used to make beer or bread has had 16 chromosomes. But now—thanks to CRISPR technology and some DNA tinkerers in China—there are living yeast with just one.

Genome organizer: We humans have our genes arranged on 46 chromosomes, yeast use 16, and there’s even a fern plant with 1260 of them. That’s just the way it is. And no one is quite sure why.

The big one: Do we really need so many chromosomes? That’s what Zhogjun Qin and colleagues at the Key Laboratory of Synthetic Biology in Shanghai wanted to know.

With CRISPR, the gene-editing tool, Qin’s team chopped out the button-like centromeres that hold each stringy chromosome together, and then started fusing them into one long chain. The result: organisms with eight, four, two, and even finally just one “single giant chromosome.”

(Excerpt) Read more at technologyreview.com ...


TOPICS: Miscellaneous; News/Current Events
KEYWORDS: chatforum; chromosome; crispr; dna; gmo; health; michaelmoore; science
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Hey, we don't know how this works, so let's tinker with it. What could go wrong?
1 posted on 08/01/2018 5:09:32 PM PDT by aimhigh
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To: aimhigh

There’s a fern with 1260 chromosomes!

I did not know that.

I thought the most genetically complex plant was the orchid.

On the other hand I was taught that one of the simplest plants was the cannabis plant, but I admit to bias.


2 posted on 08/01/2018 5:13:49 PM PDT by T-Bone Texan (I posit that there IS something left worth fighting for.)
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To: aimhigh

Yeast is yeast and west is west and never the twain shall meet...


3 posted on 08/01/2018 5:14:22 PM PDT by null and void (Equality is important, but quality is paramount.)
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To: aimhigh

I share your concerns, but.... like so many other elements of change in the new technologies that are emerging, it’s not a matter of liking it or disliking it, but accepting that it is out there, and competitors or antagonists will exploit it, whether we like it or not. So we need to master it and keep on top of what the Chinese, the Russians, the Indians, the Iranians, etc. are doing with it.


4 posted on 08/01/2018 5:14:33 PM PDT by Wally_Kalbacken
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To: aimhigh

What do you expect from commies who deny God’s existence even when the proof thereof is staring them in the face?


5 posted on 08/01/2018 5:15:23 PM PDT by Olog-hai ("No Republican, no matter how liberal, is going to woo a Democratic vote." -- Ronald Reagan, 1960)
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To: aimhigh

It isn’t nuclear war we should worry about its guy’s in clean labs.


6 posted on 08/01/2018 5:17:18 PM PDT by Rurudyne (Standup Philosopher)
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That’s just the way it is. And no one is quite sure why. …
If that is the way it is, there is a Being who made it that way. And if He did not feel the need to reveal why at this time, that is another test of faith.
The big one: Do we really need so many chromosomes? That’s what Zhogjun Qin and colleagues at the Key Laboratory of Synthetic Biology in Shanghai wanted to know. …
And why should the Author of DNA and chromosomes reveal why to those that deny His existence?

It clearly is not good enough for such people (loosely called) to see that things go awry in both Down and Turner Syndromes (one extra and one fewer chromosome respectively).

And while we are at it, let us speculate what would have happened if those building the Tower of Babel were permitted to complete it.
7 posted on 08/01/2018 5:19:57 PM PDT by Olog-hai ("No Republican, no matter how liberal, is going to woo a Democratic vote." -- Ronald Reagan, 1960)
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To: null and void

Boooooooooooooo!!!!!


8 posted on 08/01/2018 5:23:00 PM PDT by MortMan (The white board is a remarkable invention.)
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To: Olog-hai

A fall would have come in some other manner instead.

But it sure seems reckless to try to muck around with the chromosomes in the real world, and the science of the consequences may belatedly tell us at least some reasons for the partitioning. Probably something like: if it goes wrong, it will go wrong grandly.


9 posted on 08/01/2018 5:23:21 PM PDT by HiTech RedNeck (Tryin' hard to win the No-Bull Prize.)
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To: MortMan

Thank you, thank you, I’ll be here all week.

Try the veal.

Don’t bother asking the waitress out, she only has a single chromosome and doesn’t date outside her species...


10 posted on 08/01/2018 5:26:18 PM PDT by null and void (Equality is important, but quality is paramount.)
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To: aimhigh

This is not going to end well....


11 posted on 08/01/2018 5:26:39 PM PDT by PTBAA
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To: aimhigh

12 posted on 08/01/2018 5:27:44 PM PDT by BenLurkin (The above is not a statement of fact. It is either satire or opinion. Or both.)
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To: aimhigh

The demise of our species will be due to a “laboratory curiosity” gone wild.


13 posted on 08/01/2018 5:28:29 PM PDT by SpaceBar
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To: null and void

Re-engineering humanity sure would have a very bad backwards-compatibility problem!


14 posted on 08/01/2018 5:30:11 PM PDT by HiTech RedNeck (Tryin' hard to win the No-Bull Prize.)
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To: SpaceBar

All those low budget 50’s sci-fi movies were actually right.


15 posted on 08/01/2018 5:30:48 PM PDT by SpaceBar
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To: HiTech RedNeck

Not touching that one.


16 posted on 08/01/2018 5:31:29 PM PDT by null and void (Equality is important, but quality is paramount.)
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To: null and void

Well, speaking of it as a software engineer might speak.


17 posted on 08/01/2018 5:32:11 PM PDT by HiTech RedNeck (Tryin' hard to win the No-Bull Prize.)
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To: aimhigh
What could possibly go wrong?


18 posted on 08/01/2018 5:36:08 PM PDT by Petrosius
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To: T-Bone Texan

More chromosomes doesn’t necessarily mean more complex. Plants tend to go through whole genome duplications more so than animals.


19 posted on 08/01/2018 5:40:18 PM PDT by Moonman62 (Give a man a fish and he'll be a Democrat. Teach a man to fish and he'll be a responsible citizen.)
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To: aimhigh

What could go wrong?

...

Don’t you trust the Chinese to be safe?


20 posted on 08/01/2018 5:40:54 PM PDT by Moonman62 (Give a man a fish and he'll be a Democrat. Teach a man to fish and he'll be a responsible citizen.)
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