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Marijuana Compound a Novel Treatment for Alzheimer's?
Medscape Psychiatry and Mental Health ^ | 9/5/2014 | Pam Harrison

Posted on 09/05/2014 2:14:47 PM PDT by steve86

Extremely low levels of delta-9-tetrahydrocannabinol (THC), the active compound in marijuana, may offer a novel and viable treatment for Alzheimer's disease (AD), preliminary research suggests.

Investigators at the University of South Florida in Tampa found that THC both decreases the production of amyloid beta (Aβ) and inhibits its aggregation in cell cultures. In addition, it does so at extremely safe doses.

These observations have implications for a potentially new therapeutic approach to the treatment of Alzheimer's disease (AD), as researchers suggest.

"Our group believes that amyloid aggregation is the initiator of AD, so we wanted to see if THC can inhibit amyloid beta aggregation in vitro," study investigator Chuanhai Cao, PhD, a neuroscientist at the Byrd Alzheimer's Institute, College of Pharmacy, University of South Florida, told Medscape Medical News.

"And in our in vitro cell cultures, we discovered that THC inhibits amyloid beta production as well as aggregation at extremely low doses and that it enhances mitochondrial function as well. These observations suggest that THC has anti-Alzheimer's activity."

The study was published online August 27 in the Journal of Alzheimer’ Disease.


TOPICS: Culture/Society; US: Washington
KEYWORDS: alzheimers; cannabis; marijuana; medicalmarijuana; pot; thc; wod
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1 posted on 09/05/2014 2:14:47 PM PDT by steve86
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To: steve86

Online preview

http://iospress.metapress.com/content/8421pvx80144t354/?p=31e1c4ad299e41bca5743fe066d5c1c2&pi=1


2 posted on 09/05/2014 2:15:51 PM PDT by steve86 ( Acerbic by nature, not nurture)
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To: steve86

No no, this stuff makes one stark raving mad, man! Have you not seen that documentary, “Reefer Madness”?!?!?


3 posted on 09/05/2014 2:16:58 PM PDT by dware (3 prohibited topics in mixed company: politics, religion and operating systems...)
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To: steve86
My grandmother lived with us and she had Alzheimers. We would have tried it.

My very prim and proper aunt who had cancer smoked a little back in the 70's as a way to deal with her chemo...and it helped tremendously.

4 posted on 09/05/2014 2:20:10 PM PDT by RoosterRedux
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To: steve86

Do you have Alzheimer’s or are you just stoned? /S

(Note: Joking is separate from any therapeutic value, I hope it’s true, but I couldn’t resist)


5 posted on 09/05/2014 2:20:55 PM PDT by Pearls Before Swine
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To: steve86
Aggregation of amyloid beta (Aβ) is only one of the factors involved in Alzheimer's Disease but this finding is promising.

The medical marijuana community has been pushing this idea for some time.

Very low level of THC used in this study.

No evidence presented in this study that ordinary use of marijuana has therapeutic effect.

6 posted on 09/05/2014 2:21:04 PM PDT by steve86 ( Acerbic by nature, not nurture)
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To: RoosterRedux

I have a retail store 30 miles away and would not hesitant to purchase and use it for medical effect. Already have a vape “just in case”.


7 posted on 09/05/2014 2:23:13 PM PDT by steve86 ( Acerbic by nature, not nurture)
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To: steve86
THC both decreases the production of amyloid beta (Aβ) and inhibits its aggregation in cell cultures. In addition, it does so at extremely safe doses.

What is an "unsafe" dose?

8 posted on 09/05/2014 2:24:31 PM PDT by ConservingFreedom (A goverrnment strong enough to impose your standards is strong enough to ban them.)
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To: steve86

Because Marijuana has a great reputation for helping memory and mental clarity?


9 posted on 09/05/2014 2:24:44 PM PDT by nickcarraway
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To: ConservingFreedom

Yes, because, as President Obama said, Marijuana is the safest substance known to man, and only has beneficial effects.


10 posted on 09/05/2014 2:26:44 PM PDT by nickcarraway
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To: nickcarraway

Healthy people don’t have problems with amyloid beta production and the study is not relevant to them.


11 posted on 09/05/2014 2:26:53 PM PDT by steve86 ( Acerbic by nature, not nurture)
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To: steve86

>>No evidence presented in this study that ordinary use of marijuana has therapeutic effect.

Nobody needs a study for that. Use of it will relax the hell out of you, which can be very therapeutic.


12 posted on 09/05/2014 2:27:03 PM PDT by arbitrary.squid
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To: dware
“No,no, this stuff makes one stark raving mad, man! Have you not seen that documentary, “Reefer Madness”?!?!?”

I am old enough to remember that being shown in my grade school in all seriousness.

13 posted on 09/05/2014 2:27:43 PM PDT by CrazyIvan (I lost my phased plasma rifle in a tragic hovercraft accident.)
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To: dware

So, to ward off Alzheimer’s I just have to maintain a mild buzz for the rest of my life. Sounds good to me.


14 posted on 09/05/2014 2:28:01 PM PDT by glorgau
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To: steve86

WE are all chemical walking experiments after all.

Who knows what combo of stuff works for who?

Try Try again..

I look forward to home self-healing treatments of the future.

In the mean time, The Moochelle Diet is off the hospital menu.


15 posted on 09/05/2014 2:29:06 PM PDT by NormsRevenge (Semper Fi - Revolution is a'brewin!!!)
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To: arbitrary.squid
Use of it will relax the hell out of you, which can be very therapeutic.

I guess the Indica-dominant strains do that; the Sativa not so much.

16 posted on 09/05/2014 2:29:27 PM PDT by steve86 ( Acerbic by nature, not nurture)
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To: steve86

Guess what?

Also:

Taking a shot of Jack Daniels has a therapeutic effect-
Couple of glasses of MD 20/20
A few aspirins
snorting coke- or drinking Coca-Cola

LOL

This is just Rubbish- to please all of the dopers -
(while getting stoned... they think they are curing
themselves of Alzheimer’s!) lol


17 posted on 09/05/2014 2:32:30 PM PDT by mj1234
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To: steve86

I’ll have to start dosing my mother and see if it helps.


18 posted on 09/05/2014 2:32:46 PM PDT by TigersEye ("No man left behind" means something different to 0bama.)
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To: nickcarraway
Yes, because, as President Obama said, Marijuana is the safest substance known to man, and only has beneficial effects.

Why sure! Obama smoked the stuff, and look how well he is running everything now!

Then:

Now:

19 posted on 09/05/2014 2:34:21 PM PDT by DiogenesLamp (Partus Sequitur Patrem)
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To: steve86

C’mon don’t you know marijuana is the perfect substance that is a pnacea to all problems. President Obama should sign an executive order making it illegal to insult marijuana in any way.


20 posted on 09/05/2014 2:34:57 PM PDT by nickcarraway
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