[Dr. Sivana]

So ... is this bad protein found in beef, pork, chicken or tofu?

[neverdem]

Diabetes discovery: Protein pathway points to possible treatment A different version of the TXNIP story

Plant protein regulates diabetes treatment Not ready for prime time, but it could be a future drug delivery system.

FReepmail me if you want on or off the diabetes ping list.

N.B. Press releases at ScienceDaily usually link the abstract of the original citation after the reference to it with its DOI.

[bmwcyle]

PING

[Night Hides Not]

Is TXNIP development tied to ingestion of dihydrogen monoxide?

[jdege]

This sounds like they might have discovered how high blood sugar kills beta cells, but I don't anything about why diabetics end up with high blood sugar.

Another report: TXNIP Protein Pathway Discovery Could Point To Possible Diabetes Treatment

Shalev said that for some people, excessive demand on beta cells to produce insulin to counteract elevated blood sugar -- which is what's seen in type 2 diabetes, which accounts for more than 90 percent of all diabetes -- eventually stresses the beta cells, which then lose their ability to make enough insulin to meet demand. This leads to an increase in blood sugar and greater levels of TXNIP production - a vicious cycle that results in even less insulin production and more beta cell death.

Which makes me think that this may not be a path to a cure. Even if we can learn to keep high blood sugar from killing beta cells, in the face of insulin resistance, high blood sugars are still going to be causing plenty of other problems, and hyperinsulinemia causes lots of problems itself.

Seems to me the $64k question is what causes insulin resistance.