Unlike a real flight crew you can work shifts and switch among an unlimited number of pilots, copilots and weapons and ECM operators. You can even have specialist pilots for take off and landings or for air combat.
There was a contest sponsored by DARPA a couple of years ago, yes the ones who fostered internet technology, that gave a $million prize to whomever could produce an unmanned automobile through various obstacle courses. I knew right away that this was significant and profound. In the near future, "programmed" drones will be pulling eternal guard duty or "suicide" missions, completly unmanned and untended.
Imagine pushing a button from the other side of the world and a fully armed 4-wheel drive pulls out of a parking garage and goes a place of engagement. I will leave the details up to you.