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Prostate cancer drug so effective trial stopped
sfgate ^ | 6/2/12 | Victoria Colliver

Posted on 06/03/2012 12:12:44 AM PDT by LibWhacker

A new drug for advanced prostate cancer patients has proved so effective that researchers stopped the clinical trial early to give all patients a chance to receive the life-extending medication, according to a UCSF-led study released Saturday.

The hormone treatment, Johnson & Johnson's Zytiga, when added to a standard steroid therapy doubled the time it takes for the disease to progress in patients treated with the standard therapy alone, said the lead researcher, Dr. Charles Ryan, associate professor of clinical medicine at the UCSF Helen Diller Family Comprehensive Cancer Center.

(Excerpt) Read more at sfgate.com ...


TOPICS: News/Current Events
KEYWORDS: cancer; drug; prostate; zytiga

1 posted on 06/03/2012 12:13:11 AM PDT by LibWhacker
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To: LibWhacker

If this study is correct - fantastic!!!!


2 posted on 06/03/2012 12:15:47 AM PDT by svcw (If one living cell on another planet is life, why isn't it life in the womb?)
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To: LibWhacker

This sounds good. However, we have been bitten in the past by cutting testing short. I hope they closely monitor the use.


3 posted on 06/03/2012 12:49:37 AM PDT by Ingtar ("As the light begins to fade in the city on the hill")
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To: LibWhacker

So they ignored the whole point of a clinical trial.

‘We stopped the trial because the drug was working too well’ is always a red flag.

Apart from the problem of cherrypicking early (possibly idiosyncratic) results, what if the drug causes horrific side effects that don’t manifest in a truncated trial?


4 posted on 06/03/2012 12:55:37 AM PDT by agere_contra
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To: agere_contra

It’s just bad reporting, sensationalism. Drug trials go on forever in the form of data gathering and data management long after market approval.

The FDA still has to approve use on the market, based on the trial data.


5 posted on 06/03/2012 1:16:55 AM PDT by onona (So long Doc Watson, you were an inspiration.)
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To: agere_contra
Apart from the problem of cherrypicking early (possibly idiosyncratic) results, what if the drug causes horrific side effects that don’t manifest in a truncated trial?

This is a medication is one of last resort. It is not a cure but simply life prolonging. The qualification to get on it as of about last May was having literally months to live. My dad took it for about two months up till about his final 6-8 weeks. By them the chemo had taken it's toll on him. He was one it really didn't help but I possibly could have if he had been able to start it earlier. His Oncologist said he had seen good results with it in most of his other patients.

6 posted on 06/03/2012 1:34:25 AM PDT by cva66snipe (Two Choices left for U.S. One Nation Under GOD or One Nation Under Judgment? Which one say ye?)
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To: neverdem

Ping.


7 posted on 06/03/2012 1:37:55 AM PDT by oprahstheantichrist (The MSM is a demonic stronghold, PLEASE pray accordingly - 2 Corinthians 10:3-5)
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To: LibWhacker
Hmmmmm "...doubled the time it takes for the disease to progress..."

Does that mean it slowed by double or sped up by double?

8 posted on 06/03/2012 2:32:25 AM PDT by Red_Devil 232 (VietVet - USMC All Ready On The Right? All Ready On The Left? All Ready On The Firing Line!)
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To: agere_contra
>"what if the drug causes horrific side effects that don’t manifest in a truncated trial?"

Apparently you haven't watched TV in the last decade.

You call Kyles dad.

9 posted on 06/03/2012 3:32:09 AM PDT by rawcatslyentist ("Behold, I am against you, O arrogant one," Jeremiah 50:31)
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To: LibWhacker
While there was a significant delay in the development of radiograpic evidence of distant metastasis on bone imaging (which may or may not have been symptomatic), there was only a statistical trend toward improvement in overall survival. (Minimal difference compared to placebo, which didn't reach statistical significance). This has to be weighed against the cost of $5000 per month for the drug.
10 posted on 06/03/2012 3:51:08 AM PDT by SC DOC
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To: svcw

Yawn...
Relax. It will still be 15 years before it’s on the shelf.

Same thing happened with a drug that treats colon cancer. 90% effective. Don’t believe me? It’s called DFMO.

Yet people die from colon cancer every day. Thank FDA for that.

I am sure that most doctors hope they can “cure” their patients. But big pharma doesn’t make as much money “curing” a disease as they do “treating” a disease. When your insurance runs out, you’re toast.


11 posted on 06/03/2012 3:58:25 AM PDT by djf ("There are more old drunkards than old doctors." - Benjamin Franklin)
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To: djf

DFMO caused hearing loss so doctors didn’t want to use it.

It wasn’t the FDA, it was the clinicians. They are restarting the trials with longer, lower doses. My dad died of colon cancer.

The problem is that the press screams “Miracle cure!” when they have no clue how the trials are conducted. It may have worked with a person or two but not everyone. DFMO’s effects turned out to be modest.


12 posted on 06/03/2012 4:52:28 AM PDT by netmilsmom (Romney scares me. Obama is the freaking nightmare that is so bad you are afraid to go back to sleep)
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To: agere_contra

It’s an accepted and legitimate part of doing clinical trials — if the principle investigator can keep his meddling mitts off the data and if he bothered to recruit a sufficient number of study subjects to begin with, which unfortunately, is not the case in many instances.


13 posted on 06/03/2012 4:56:11 AM PDT by LibWhacker
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To: Red_Devil 232
Hmmmmm "...doubled the time it takes for the disease to progress..." Does that mean it slowed by double or sped up by double?

Here's a helpful anology: You're waiting in line at a Wal Mart checkout. There are two old ladies with change purses out, and 3 fat ladies with food stamps and an assortment of old gift cards in their hands. The prognosis is that it will serve to double the time it takes you to progress in the line.

14 posted on 06/03/2012 5:01:11 AM PDT by trebb ("If a man will not work, he should not eat" From 2 Thes 3)
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To: Red_Devil 232

I take it to mean that it doubles the time it takes to progress from one stage of the disease to the next. Or from stage one to end stage. Or something similar.

Which is a good thing, IF the effect is real and not imagined. Often it’s the latter, imagined by an overly enthusiastic principle investigator who has stars in his eyes and has been meddling with the data and abusing his poor statistician since the day he hired him, if he ever even bothered to hire one.


15 posted on 06/03/2012 5:08:27 AM PDT by LibWhacker
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To: netmilsmom

A good friend of mine died from it also.

OK, so here’s your choicea.
Die.
Lose (not even proven yet) a bit of your hearing.

Need I ask?

Same deal with the EDTA Chelation studies. Started around 2001. Supposed to be a seven or ten year study, whatever.

Latest I hear is it’s still going on, any release of initial results are being delayed yada yada yada even though EDTA has been KNOWN to be an effective treatment for some forms of heart problems since like NINETEEN TWENTY OR SO...!!!


16 posted on 06/03/2012 5:12:51 AM PDT by djf ("There are more old drunkards than old doctors." - Benjamin Franklin)
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To: djf

>>Lose (not even proven yet) a bit of your hearing.<<

No, everyone who took it lost their hearing.
And it only had modest success.

Seriously, we were fighting when this was going on. It was a false hope by the press.


17 posted on 06/03/2012 5:33:27 AM PDT by netmilsmom (Romney scares me. Obama is the freaking nightmare that is so bad you are afraid to go back to sleep)
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To: LibWhacker; All
Four Clinical Studies Prove Cayenne Pepper Cures Prostate Cancer
18 posted on 06/03/2012 6:22:57 AM PDT by PeaceBeWithYou (De Oppresso Liber! (50 million and counting in Afghanistan and Iraq))
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To: djf
LOLOL! My choices are DIE, or spend the rest of my life walking around saying "What?"

Easy choice, and it should be mine to make...

19 posted on 06/03/2012 6:29:16 AM PDT by who knows what evil? (G-d saved more animals than people on the ark...www.siameserescue.org.)
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To: LibWhacker

Fantastic....!!!

But I do hope it is too late for Chavez.


20 posted on 06/03/2012 6:31:27 AM PDT by Gatún(CraigIsaMangoTreeLawyer)
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To: agere_contra

THAT trial has stopped due to efficacy. If you read the article, the drug was approved last year. This study looked at the use of zytiga in conjunction with a steroid therapy for men with metastasized prostate cancer who haven’t had chemo treatment.

The combination proved so successful stopping the trial was the ethical thing to do. You don’t watch people die just to gather a bit more data. There will be other trials, designed differently, to make the case for this treatment.

Also, J&J couldn’t stop that trial without consulting the FDA. There was no “cherry picking”. Johnson & Johnson wouldn’t risk billions of dollars on trying to trick the FDA that their drug works.


21 posted on 06/03/2012 6:57:24 AM PDT by brewer1516
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To: djf

“Relax. It will still be 15 years before it’s on the shelf.”

Seriously, did ANYONE actually read the article? Sheesh!

And what I gather from your comments about evil “Big Pharma” I see you make similar judgments about things equally uninformed.


22 posted on 06/03/2012 7:03:20 AM PDT by brewer1516
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To: rawcatslyentist

What do you call Kyle’s Dad? Flipper!


23 posted on 06/03/2012 2:25:53 PM PDT by Museum Twenty (To see myself as others see me? Sounds like a terrible fate! I take great comfort in self-delusion.)
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To: trebb

To further the analogy:

When all five decide to pay by Check, that’s the Gov’t getting involved.


24 posted on 06/03/2012 2:28:07 PM PDT by Museum Twenty (To see myself as others see me? Sounds like a terrible fate! I take great comfort in self-delusion.)
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To: brewer1516

You know, if you say things like “You don’t watch people die just to gather a bit more data,” you’ll never be a Czar in the current administration.
Just sayin’.


25 posted on 06/03/2012 2:31:51 PM PDT by Museum Twenty (To see myself as others see me? Sounds like a terrible fate! I take great comfort in self-delusion.)
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To: neverdem

ping


26 posted on 06/03/2012 3:00:22 PM PDT by GOPJ ( "A Dog In Every Pot" - freeper ETL)
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