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Stinky Frogs an Antibiotic Treasure Trove
Scientific Computing ^ | 1/27/12

Posted on 01/27/2012 10:06:42 AM PST by null and void

Courtesy of the American Chemical Society

Some of the nastiest smelling creatures on Earth have skin that produces the greatest known variety of anti-bacterial substances that hold promise for becoming new weapons in the battle against antibiotic-resistant infections, scientists are reporting. Their research on amphibians so smelly (like rotten fish, for instance) that scientists term them “odorous frogs” appears in ACS’ Journal of Proteome Research and is titled  “Extremely Abundant Antimicrobial Peptides Existed in the Skins of Nine Kinds of Chinese Odorous Frogs.”

Yun Zhang, Wen-Hui Lee and Xinwang Yang explain that scientists long have recognized frogs’ skin as a rich potential source of new antibiotics. Frogs live in warm, wet places where bacteria thrive and have adapted skin that secretes chemicals, known as peptides, to protect themselves from infections. Zhang’s group wanted to identify the specific antimicrobial peptides (AMPs), and the most potent to give scientists clues for developing new antibiotics.

They identified more than 700 of these substances from nine species of odorous frogs and concluded that the AMPs account for almost one-third of all AMPs found in the world, the greatest known diversity of these germ-killing chemicals. Interestingly, some of the AMPs have a dual action, killing bacteria directly and also activating the immune system to assist in the battle.

The authors acknowledge funding from the National Basic Research Program of China and The National Natural Science Foundation of China.


TOPICS: Culture/Society
KEYWORDS: frog
A new antibiotic could keep you from croaking...
1 posted on 01/27/2012 10:06:46 AM PST by null and void
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To: null and void

Stinky Frog...
I’m thinking of changing my freeper name...


2 posted on 01/27/2012 10:11:58 AM PST by Repeal The 17th (We have met the enemy and he is us.)
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To: Repeal The 17th; frog in a pot

frog in a pot will be jealous...


3 posted on 01/27/2012 10:14:03 AM PST by null and void (Day 1102 of America's ObamaVacation from reality [Heroes aren't made, Frank, they're cornered...])
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To: null and void

As a three time mrsa survivor, this is good news.


4 posted on 01/27/2012 10:15:07 AM PST by goseminoles
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To: null and void

5 posted on 01/27/2012 10:19:22 AM PST by BlueLancer (Secede?! Y'all better just be thankful we don't invade ...)
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To: null and void; smokingfrog; frog in a pot

and don’t forget smoking frog


6 posted on 01/27/2012 10:21:15 AM PST by Repeal The 17th (We have met the enemy and he is us.)
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To: null and void
Maybe they should investigate all stinky substances for antibiotic properties.
7 posted on 01/27/2012 10:30:02 AM PST by DannyTN
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To: BlueLancer

“Milton: We use only the finest baby frogs, dew picked and flown from Iraq, cleansed in finest quality spring water, lightly killed, and then sealed in a succulent Swiss quintuple smooth treble cream milk chocolate envelope and lovingly frosted with glucose.

Praline: That’s as maybe, it’s still a frog.

Milton: What else?

Praline: Well don’t you even take the bones out?

Milton: If we took the bones out it wouldn’t be crunchy would it? “


8 posted on 01/27/2012 10:32:32 AM PST by WayneS (Comments now include 25% MORE sarcasm for no additional charge...)
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To: null and void

Is this another article on the French lack of hygiene ?


9 posted on 01/27/2012 10:38:50 AM PST by Timocrat (Ingnorantia non excusat)
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To: null and void

Did someone call for the French?


10 posted on 01/27/2012 11:38:01 AM PST by Doulos1 (Bitter Clinger Forever!)
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To: null and void

Stinky Frog?
Is than anything like Crunchy Frog?


11 posted on 01/27/2012 11:41:58 AM PST by BuffaloJack (Defeat Obama. End Obama's War On Freedom.)
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To: Repeal The 17th; FReepers; null and void; Lady Jag
Sick of not getting the REAL news?

There's a solution...


12 posted on 01/27/2012 11:51:51 AM PST by smokingfrog ( sleep with one eye open (<o> ---)
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To: smokingfrog



13 posted on 01/27/2012 1:28:13 PM PST by Lady Jag (Laws are spider webs through which the big flies pass and the little ones get caught)
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To: null and void; Repeal The 17th
frog in a pot will be jealous...

I'm cool with it, I buy my underarm deodorant by the pallet at Sam's Club.

(Just between the three of us, having watched our nation's politics for the past 40 years, I believe we are all frogs in a pot.)

14 posted on 01/27/2012 2:15:31 PM PST by frog in a pot
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To: frog in a pot

Feels more like a Jacuzzi...


15 posted on 01/27/2012 2:43:15 PM PST by null and void (Day 1102 of America's ObamaVacation from reality [Heroes aren't made, Frank, they're cornered...])
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