Posted on 08/24/2009 12:21:00 PM PDT by Berlin_Freeper
L.A. County coroner's officials found lethal levels of the powerful anesthetic propofol after examining Michael Jackson's body, according to a search warrant affidavit unsealed today in Houston.
According to the search warrant, Jackson's doctor, Conrad Murray, told LAPD detectives that he had been treating Jackson for insomnia for about six weeks. He had been giving Jackson 50 milligrams of propofol every night using an intravenous line, according to the court records.
But Murray told detectives that he feared Jackson was forming an addiction and began trying to wean the pop star off the drugs. He lowered the dosage to 25 milligrams and mixed it with two other sedatives, lorazepam and midazolam. On June 23, two days before Jackson's death, he administered two medications and withheld the propofol.
On the morning Jackson died, Murray tried to induce sleep without using propofol, according to the affidavit. He said he gave Jackson valium at 1:30 a.m. When that didn't work, he said he injected lorazepam intravenously at 2 a.m. At 3 a.m., when Jackson was still awake, Murray administered midazolam.
Over the next few hours, Murray said he gave Jackson various drugs. Then at 10:40 a.m., Murray administered 25 milligrams of propofol after Jackson repeatedly demanded the drug, according to the court record.
(Excerpt) Read more at latimesblogs.latimes.com ...
How about a warm glass of milk??
If Jackson didn’t take uppers, he wouldn’t need downers.
As long as he’s pushin daisies instead of molesting kids, I don’t care.
Benadryl works too! MJ’s concience got the best of him. Along with his fall from stardom. Time to drug it up.
You know you’re in trouble when you need general anesthesia to fall asleep at night. I’m surprised he hung on for so long.
That $600,000 contract sure looked good to Murray when he signed it.
“How about a warm glass of milk??”
Or even some Jesus Juice.
Well, he finally put Jackson to sleep, alright...
How about a warm glass of milk??
####
Or a constructive life, honest and well led, in service to God and one’s family.
Should then, be able to sleep like a baby....
That’s why he was known as the King of Propofol.
I would have thought that Michael would have figured out the dosage after experimenting on eight year-old boys and such ...
LOL.
I was just thinking the same thing.
Jeesh
Versed is a sedative, anxiety, and anesthesia medication that is used before or during surgeries and medical procedures
“If Jackson didn’t take uppers, he wouldn’t need downers”
Unless I missed something, none of the meds talked about are classified as “uppers”. Indeed, that is the reason that theses combinations can prove so lethal.
“Murray has already acknowledged obtaining and administering propofol to Jackson the morning that he died. In an interview with police, Murray told them that he left Jackson alone under the influence of the medication to make telephone calls to his Houston office and family members.
When he returned, he discovered Jackson was not breathing.”
Negligence x2.
One of the folks I know at the skeet range is a anesthesiologist and said this stuff is bad news if administered by a non-specialist, especially if resuscitation equipment is not present.
Wow...amazing glimpse into how celebrities can be drugged up legally. Imagine an average citizen having a doctor that will administer drugs through an IV at your beck and call.
That is not a lot of propofol. That is not a fatal dose or even near fatal. If the Coroners report said he had an overdose of Propofol, the 25mgs is not an accurate statement.
No, but that wasn't the poster's point. The point was that, if Jackson were not getting high ("uppers"), he would not need those heavy dosages of anesthetics ("downers") to go to sleep.
I, however, plead ignorance on such details. I do know that something is seriously wrong if you are taking a general anesthetic to go to sleep at night.
If only Michael Jackson could afford good health care.
And with the cocktail of drugs supposedly given for insomnia all not working, I think that is an indication of just how buried in drug addiction Jackson had fallen.
What a sad statement. One who was once on top of the world and had everything, made a bunch of really bad choices (as is so sadly common in the industry), and died nothing more than a has-been druggie.
And worse - what did that so-called family of his actually do to help him? They are all a bunch of enablers who had more to gain by his death than by his continued life in the sewer.
Perhaps it was when mixed with lorazepam and midazolam and valium.
Much of the investigation has focused on propofol — a drug typically administered by anesthesiologists during surgery — and whether Murray’s decision to give it to Jackson as a sleep aid outside a hospital setting reaches a level of negligence required for an involuntary manslaughter charge.
Here's part of the warning section from the prescribing information:
WARNINGS
For general anesthesia or monitored anesthesia care (MAC) sedation, DIPRIVAN Injectable Emulsion should be administered only by persons trained in the administration of general anesthesia and not involved in the conduct of the surgical/diagnostic procedure. Patients should be continuously monitored, and facilities for maintenance of a patent airway, artificial ventilation, and oxygen enrichment and circulatory resuscitation must be immediately available.
He was using the drug outside of its indicated use and in a way SPECIFICALLY warned about by the manufacturer. This guy could do hard time...a poster boy for practicing awful celebrity medicine (that is, give the celebs anything they ask for).
We could take a full % point off the share of GDP spent on healthcare now that Jackson is no more!
Well, I can’t imagine Jackson needing such a powerful drug as sleep medication if he wasn’t taking uppers to get through the day. It just doesn’t make sense otherwise. We’ll see what the full autopsy reports reveal.
How about some Ovaltine?
What about that dosage in conjunction with all the other downers he gave Jackson? Death cocktail?
Not really. The LD50 (= lethal dose to 50% of the rats taking it) is 500mg/kg. This would be 25000 mg for a 50kg person. It is actually a very safe anesthetic as it sequesters to the fat tissue very quickly and thus the effect is not long. There is something wrong with the story Jacksons Dr. is telling.
I suspect that an IV bottle was hung and the pump for the IV was programed wrong and he had a whole bottle bolused (given quickly) without anyone watching him. You could achieve a fatal dose this way. If you bolused a bottle (1000 mg) you could achieve a very high level in the blood stream that could cause respiratory arrest. Although the total mg would not be = to the LD50 it could reach this level in the blood stream and thus cause death.
Yes that is contributory but the coroners report indicated a fatal dose of propofol. If that is accurate there was a hell of lot more propfol given than the Dr. indicated.
DING DING DING, WE HAVE THE WINNING ANSWER!
Thanks, I’m only experienced with Scotch.
Or a shot of bourbon.
One of the indications of the drug is euphoria. I bet with a whole bag of the stuff, Jackson thought he was in a room full of little boys.
Oddly enough they both work on the same areas of the brain except Scotch is not near as potent but it does last longer. I recommend Scotch highly, it is cheaper and tastes good. Your anesthesiats advice about equipment to resuscitate is 100% correct. Anytime anesthesia is administered you MUST HAVE this gear. STICK TO SCOTCH but fine old Cognac should be considered! :)
Should have used Seroquel. Works wonders and you don’t wake up doped; you do wake up which is a plus.
A. Boys' underwear, half off!
Obamacare would have saved Michael Jackson...
He should have just tried over-the-counter melatonin.
As little Ralphie Peters would say,
“S*n*fab*tch!”
Any chance we could have Murray sent to the White House?
Excellent points! Thank you!
Yeah, where was his family?
“STICK TO SCOTCH”
Well, since the term “scotch” should only be used for whiskey distilled in Scotland, and Scotland is now a terrorist state, might I suggest some Kentucky bourbon? Knob Creek is my favorite. Or at least some Irish whiskey like Jameson’s or Bushmill’s? No more johnny walker for me.
So, he was the "King of Prop"! ((ducking))
My understanding is that the family attempted intervention and he had them locked out by his security.
Death by decimal point. Happens all the time.
Thank God this quack is black or we would have had race riots all across America !
I have a friend who is an anesthesiologist.
He jokingly told me that if MJ had hired him, he would still be alive today.
An anesthesiologist is the only person who can give these drugs safely- not a cardiologist.
He also told me that if you mix ketamine with less of the propofol, patients do not get into trouble with respiratory issues.
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