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Cure for radiation sickness found?
Ynet ^ | Ronen Bergman

Posted on 07/19/2009 5:11:19 PM PDT by Michel12

Medication that can protect humans against nuclear radiation has been developed by Jewish-American scientists in cooperation with a researcher and investors from Israel. The full story behind the dramatic discovery will be published in Yedioth Ahronoth's weekend edition.

The ground-breaking medication, developed by Professor Andrei Gudkov – Chief Scientific Officer at Cleveland BioLabs - may have far-reaching implications on the balance of power in the world, as states capable of providing their citizens with protection against radiation will enjoy a significant strategic advantage vis-à-vis their rivals.

For Israel, the discovery marks a particularly dramatic development that could deeply affect the main issue on the defense establishment's agenda: Protection against a nuclear attack by Iran or against "dirty bomb" attacks by terror groups.

Gudkov's discovery may also have immense implications for cancer patients by enabling doctors to better protect patients against radiation. Should the new medication enable cancer patients to be treated with more powerful radiation, our ability to fight the disease could greatly improve.

The process that led up to the medical innovation dates back to 2003, when Professor Gudkov came up with the idea of using protein produced in bacteria found in the intestine to protect cells from radiation.

Gudkov recounted an experiment he held with two groups of mice.

"We exposed both groups to lethal radioactive radiation," he said. "All the mice in the control group died within a short period of time. A few days later, when I approached the cage with the mice that received the protein, I could see that they're ok, that they're alive. They survived. It's hard to describe the joy all of us felt. We realized that finally, after so many years and so many experiments and frustrations, we made a breakthrough that may save the lives of millions."

Prof. Gudkov published the findings of the protein experiment in Science, the world's leading scientific journal; however, the discovery of the medication was kept secret until now, while Gudkov and his associated waited for the results of two series of critical tests examining the medication's effectiveness and safety.

The first series of tests included experiments on more than 650 monkeys. Each test featured two groups of monkeys exposed to radiation, but only one group was given the medication. The radiation dosage was equal to the highest dosage sustained by humans as result of the Chernobyl mishap.

The experiment's results were dramatic: 70% of the monkeys that did not receive the cure died, while the ones that survived suffered from the various maladies associated with lethal nuclear radiation. However, the group that did receive the anti-radiation shot saw almost all monkeys survive, most of them without any side-effects. The tests showed that injecting the medication between 24 hours before the exposure to 72 hours following the exposure achieves similar results.

Another test on humans, who were given the drug without being exposed to radiation, showed that the medication does not have side-effects and is safe. Prof. Gudkov's company now needs to expand the safety tests, a process expected to be completed by mid-2010 via a shortened test track approved for bio-defense drugs. Should experiments continue at the current rate, the medication is estimated to be approved for use by the FDA within a year or two.

The company's subcontractor in Europe is already prepared to embark on mass production. Meanwhile, emergency regulations in Israel allow the government to purchase drugs on short notice, even if they are still in the process of being approved. Notably, the medication in question is not a vaccine, but rather, a preventative drug administered via one or several shots.

The medication works by suppressing the "suicide mechanism" of cells hit by radiation, while enabling them to recover from the radiation-induced damages that prompted them to activate the suicide mechanism in the first place.

Prof. Gudkov heads a group of Jewish-American scientists and has cooperated with an Israeli researcher and Israeli investors. A large part of the revolutionary medication's development process was funded by the US Defense and Health departments, which thus far earmarked $40 million to the project. About two weeks ago, the US Defense Department announced that in light of the successful tests, it will continue to fund the project.

The Israeli scientist involved in the research, Dr. Elena Feinstein, made Aliyah to Israel in 1985 and for many years served as a cancer researcher at the Weizmann Institute of Science. Dr. Feinstein met Prof. Gudkov while they worked together in Moscow and was among the founders of the company, serving as its deputy director for some time.

Today, Feinstein works for an Israel company engaged in cancer research and continues to cooperate with Gudkov. Referring to the innovative medication, she says: "Both its effectiveness and safety had been proven. It is stable, safe, and easy to inject."

Both Feinstein and Gudkov stress that the innovative drug does not provide 100% protection against radioactive damage. However, should the discovery announced by the scientists meet all the required tests and permits, it may change the 21st Century.


TOPICS: Israel; News/Current Events; War on Terror
KEYWORDS: cure; radiation
Could be a game changer!
1 posted on 07/19/2009 5:11:20 PM PDT by Michel12
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To: Michel12

My money is on this being overblown hype.


2 posted on 07/19/2009 5:14:52 PM PDT by ruination
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To: Michel12

A game changer for mostly politicians, as if they’d hand that out to citizens.


3 posted on 07/19/2009 5:17:08 PM PDT by wastedyears (The Tree is thirsty and the hogs are hungry.)
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To: ruination

http://www.chattershmatter.com/2008/04/11/experimental-drug-protects-mice-and-monkeys-from-radiation/


4 posted on 07/19/2009 5:17:16 PM PDT by Michel12
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To: Michel12

If this unnamed protein suppresses apoptosis, then recipients of the, what, vaccine, who have diagnosed or undiagnosed cancers are going to experience rapid metastasis.

It’s still quite an advancement, so this is should not discredit the discovery. But, it should give certain people pause.


5 posted on 07/19/2009 5:17:41 PM PDT by RegulatorCountry
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To: Michel12

If a nuclear bomb detonates on a city, I was always taught that it would be uninhabitable for hundreds of years. How is it that Hiroshima and Nagasaki are thriving cities today?


6 posted on 07/19/2009 5:18:18 PM PDT by Hot Tabasco (Who's your Long Legged MacDaddy?)
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To: RegulatorCountry

That was my first thought.


7 posted on 07/19/2009 5:20:14 PM PDT by Gondring (Paul Revere would have been flamed as a naysayer troll and told to go back to Boston.)
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To: Michel12
http://www.istockanalyst.com/article/viewiStockNews/articleid/3357448

The drug developed by Professor Andrei Gudkov may affect the future balance of world powers, the paper said, and will offer cancer sufferers better protection as they undergo radiation treatment.

Now that may be a game changer,
in radiation therapy patients

8 posted on 07/19/2009 5:21:22 PM PDT by HangnJudge
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To: Michel12
"Could be a game changer!"

NASA is going to want some for the Mars mission!!!

9 posted on 07/19/2009 5:21:37 PM PDT by Errant
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To: RegulatorCountry
You have more on it here http://www.scientificamerican.com/article.cfm?id=new-drug-protects-against-radiation-damage
Previous studies have found that cancerous cells use nuclear factor kappa-beta--a transcription factor, or protein that turns on or off a gene's protein-making ability--to outlive normal cells and grow out of control. But healthy cells in the gut switch on the same transcription factor when they interact with benign and beneficial bacteria that reside there. Specifically, the protein flagellin in some of the microorganisms' whiplike tails (which they use for propulsion) binds with a receptor on the gut cell and triggers the production of the transcription factor. So, in an effort to steel healthy cells against radiation damage, Gudkov, chairman of the cell stress biology department at Roswell Park Cancer Institute in Buffalo, N.Y., and his colleagues purified a batch of flagellin and injected it into mice 30 minutes before exposing them to lethal doses of radiation. The injection not only protected the mice's cells but also toughened them against the effects of free radicals (molecules that can damage DNA or genetic material inside them) as well as beefed up the animal's immune systems. Mice without the injection died after the radiation treatments. "Never before has a single agent been capable of doing all three things together," Gudkov says.
10 posted on 07/19/2009 5:22:48 PM PDT by Michel12
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To: Hot Tabasco
If a nuclear bomb detonates on a city, I was always taught that it would be uninhabitable for hundreds of years. How is it that Hiroshima and Nagasaki are thriving cities today?

That's nothing.
We blew up over 1000 nukes just outside of Las Vegas.


11 posted on 07/19/2009 5:23:50 PM PDT by Bon mots
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To: Michel12
But can this therapy cure of from Delta rays?


12 posted on 07/19/2009 5:25:25 PM PDT by LiberConservative (I think Liberals are idiots and I VOTE!)
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To: Michel12
There certainly is no conflict of interest here, is there.

My career is in cancer research, and I do consulting for biotechs, so I know how this little corner of the world works. My sense is that this will all be but a memory in 5-10 years. Probably not a fond memory, except possibly for company executives.
13 posted on 07/19/2009 5:25:53 PM PDT by ruination
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To: Michel12

I hope this is true for Israel’s sake..... I’ll keep watching


14 posted on 07/19/2009 5:27:50 PM PDT by bareford101
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To: ruination

On the other hand, there is a lot of good science that comes from industry. Plus, university researchers have just as many conflicts of interest as those working in industry; probably more so.


15 posted on 07/19/2009 5:30:37 PM PDT by Kirkwood
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To: Michel12
I wonder if the announcement is intended to dissuade Iran from nuking. Obamacare jokes Obama jokes
16 posted on 07/19/2009 5:32:02 PM PDT by tbw2 (Freeper sci-fi - "Humanity's Edge" - on amazon.com)
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To: bareford101

This bears indirectly on that promise of God that the Jews would be a blessing to all of mankind.


17 posted on 07/19/2009 5:32:50 PM PDT by Buddygirl
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To: Michel12
The process that led up to the medical innovation dates back to 2003, when Professor Gudkov came up with the idea of using protein produced in bacteria found in the intestine to protect cells from radiation.

Hmmm... Maybe it is a varient on this

http://www.pnas.org/content/101/8/2452.abstract

Acute injury to the intestinal mucosa is a major dose-limiting complication of abdominal radiation therapy. We studied the role of the transcription factor NF-κB in protection against radiation-induced apoptosis in the intestinal epithelium in vivo. We use mice in which NF-κB signaling through IκB-kinase (IKK)-β is selectively ablated in intestinal epithelial cells to show that failure to activate epithelial cell NF-κB in vivo results in a significant increase in radiation-induced epithelial cell apoptosis. Furthermore, bacterial lipopolysaccharide, which is normally a radioprotective agent, is radiosensitizing in IKKβ-deficient intestinal epithelial cells. Increased apoptosis in IKKβ-deficient intestinal epithelial cells was accompanied by increased expression and activation of the tumor suppressor p53 and decreased expression of antiapoptotic Bcl-2 family proteins. These results demonstrate the physiological importance of the NF-κB system in protection against radiation-induced death in the intestinal epithelium in vivo and identify IKKβ as a key molecular target for radioprotection in the intestine. Selective preactivation of NF-κB through IKKβ in intestinal epithelial cells could provide a therapeutic modality that allows higher doses of radiation to be tolerated during cancer radiotherapy.

18 posted on 07/19/2009 5:37:43 PM PDT by HangnJudge
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To: Hot Tabasco

“If a nuclear bomb detonates on a city, I was always taught” that it would be uninhabitable for hundreds of years. How is it that Hiroshima and Nagasaki are thriving cities today?”

We cleaned it up for them.


19 posted on 07/19/2009 5:39:12 PM PDT by Cheetahcat (Zero the Wright kind of Racist! We are in a state of War with Democrats)
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To: RegulatorCountry

That was my initial thought as well. The “Cell Suicide Mechanism” is natures way of preventing damaged or abnormal cells from reproducing.


20 posted on 07/19/2009 5:40:15 PM PDT by Blackhawk (God said it, I believe it, That settles it.)
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To: HangnJudge
And Subsequently...

http://www.stormingmedia.us/42/4243/A424344.html

Abstract: The major goal of the program is identification of novel radioprotectants of Mycoplasma origin. The program consisted of two branches; screening of Mycoplasma strains for anti-apoptotic factors; and testing of predicted candidates for radioprotective activity. Both approaches were successfully implemented and yielded positive results. First, we have found and are currently characterizing a strong anti-apoptotic activity in the lysates of M. arginini. Second, an extremely potent radioprotectant, named CBLB601, structurally related to Mycoplasma lipopeptides was discovered. We have optimized CBLB601 administration regime for reaching maximal radioprotection as well as embarked upon characterization of its toxicological and pharmacological profiles. CBLB601 showed remarkable efficacy, being capable of protecting 100% of treated mice from supralethal 10Gy total body irradiation dose with evident rescuing lymphoid organs. Initial structure-function analysis of CBLB601 led to the understanding that radioprotection is conferred by stimulation of TLR2/TLR6 but not TLR2/TLR1 dimers.

21 posted on 07/19/2009 5:41:37 PM PDT by HangnJudge
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To: HangnJudge

And this patent application...

http://www.google.com/patents?hl=en&lr=&vid=USPATAPP11421964&id=l56iAAAAEBAJ&oi=fnd&dq=radioprotection+bacterial+lipopolysaccharide+Andrei+Gudkov+


22 posted on 07/19/2009 5:43:42 PM PDT by HangnJudge
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To: Michel12
Cure for radiation sickness found?

Now the only thing missing is a cure to combat the effects of the bomb blast. If somebody could develop such a thing, nuclear bombs could be rendered useless.
23 posted on 07/19/2009 5:45:25 PM PDT by adorno (Where is Branch 4?)
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To: Kirkwood
I agree that there is some level of conflict of interest across the board in scientific research. Academics need to publish and get grant funding and biotechs and pharma need investor money. I'm just saying this case particularly doesn't smell right to me.

In the first place, why would you want to prevent apoptosis in cells that have been genetically damaged by radiation? This makes *no* sense. Apoptosis is how the body protects itself from tumorigenesis. In any case, even if this protein did help people survive radiation exposure, you'd just be left with a huge jump in things like leukemia. Not exactly a game changer.

The whole thing reads like an amateurish PR piece designed to fool the unwitting public.

If it works, fantastic, but I seriously doubt it will do anything more than benefit its proponents bank accounts.
24 posted on 07/19/2009 5:48:46 PM PDT by ruination
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To: Michel12
Two points:

1) does the medication have to be introduced to the patient within the -24 to +72 hour time frame? Can it be introduced earlier and still be effective? If so, how much earlier?

2) wouldn't an enemy of Israel attempt to strike immediately knowing this miracle medication would be available in the near future?

25 posted on 07/19/2009 5:55:20 PM PDT by immadashell
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To: Hot Tabasco
If a nuclear bomb detonates on a city, I was always taught that it would be uninhabitable for hundreds of years. How is it that Hiroshima and Nagasaki are thriving cities today?

People can point to radioactive isotopes that have very long half lives, as a way of overhyping how radiation makes things uninhabitable forever.

But they are missing something basic. It is the isotopes with very short half lives, that disappear quickly, which are the most dangerous. They put out lots of radiation in a short time. An isotope that lasts a very long time, puts out only a tiny amount of radiation over the same amount of time. The only exception to this rule is when an isotope mimics a key mineral in a sensitive part of the body, like radioactive iodine hurting the thyroid. Or radioactive calcium hurting bone marrow. That's why they give iodine after radiation leak, to try to saturate thyroid with good iodine so its less prone to absorbing the radioactive iodine.
26 posted on 07/19/2009 6:06:11 PM PDT by Mount Athos (A Giant luxury mega-mansion for Gore, a Government Green EcoShack made of poo for you)
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To: Mount Athos

Thank you for the explanation


27 posted on 07/19/2009 6:09:44 PM PDT by Hot Tabasco (Who's your Long Legged MacDaddy?)
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To: AdmSmith; Berosus; bigheadfred; Convert from ECUSA; dervish; Ernest_at_the_Beach; Fred Nerks; ...
For Israel, the discovery marks a particularly dramatic development that could deeply affect the main issue on the defense establishment's agenda: Protection against a nuclear attack by Iran or against "dirty bomb" attacks by terror groups.

28 posted on 07/19/2009 6:24:02 PM PDT by SunkenCiv (https://secure.freerepublic.com/donate/__Since Jan 3, 2004__Profile updated Monday, January 12, 2009)
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To: Buddygirl

As a believer, I agree with you!!


29 posted on 07/19/2009 6:50:30 PM PDT by bareford101
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To: adorno

.............Now the only thing missing is a cure to combat the effects of the bomb blast. If somebody could develop such a thing, nuclear bombs could be rendered useless.............

“Now fellow survivors, this is the EIB network. If you can hear me, you are probably only under 50 feet of concrete debris!

Now, crawl out of there, and report immediately to your local Barack H. Omama National Medical Clinic (BHONMC.gov) for immediate treatment. However, we must warn you that if you have a bloody T shirt, or facial lesions, you will need to receive further diagnosis and treatment approval from the nearest doctor within 50 miles of your current position!

On MapQuest enter your position, and your intended destination!

BBBTTTZZZZZZZTTTTT! Oh sorry, the net is down!

Good luck, and have a nice life!


30 posted on 07/19/2009 7:06:28 PM PDT by aShepard ("OK Class: repeat after me: "BUSH BAD- OBAMA SAVIOR OF MANKIND")
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To: adorno

.............Now the only thing missing is a cure to combat the effects of the bomb blast. If somebody could develop such a thing, nuclear bombs could be rendered useless.............

“Now fellow survivors, this is the EIB network. If you can hear me, you are probably only under 50 feet of concrete debris!

Now, crawl out of there, and report immediately to your local Barack H. Omama National Medical Clinic (BHONMC.gov) for immediate treatment. However, we must warn you that if you have a bloody T shirt, or facial lesions, you will need to receive further diagnosis and treatment approval from the nearest doctor within 50 miles of your current position!

On MapQuest enter your position, and your intended destination!

BBBTTTZZZZZZZTTTTT! Oh sorry, the net is down!

Good luck, and have a nice life!


31 posted on 07/19/2009 7:06:43 PM PDT by aShepard ("OK Class: repeat after me: "BUSH BAD- OBAMA SAVIOR OF MANKIND")
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To: Buddygirl

That particular promise of God that the Jews would be a blessing directly refers to the Birth of Christ who was born and raised as a practicing Jew.

The Blessing refers to the Word of God protected through the Old testament scribes and priests and the fulfillment by Christ in the new Testament which was foretold in the old testament.

Christ is THE blessing while the Jewish nation was the vessel that the blessing came through.


32 posted on 07/19/2009 8:23:38 PM PDT by dglang
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To: dennisw; Cachelot; Nix 2; veronica; Catspaw; knighthawk; Alouette; Optimist; weikel; Lent; GregB; ..
Middle East and terrorism, occasional political and Jewish issues Ping List. High Volume

If you’d like to be on or off, please FR mail me.

..................

33 posted on 07/20/2009 4:57:14 AM PDT by SJackson (the number-one job facing the middle class...a three-letter word: jobs. J-O-B-S. Jobs)
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To: ruination

Okay, help this layman out with this: If this protective protein attaches to all cells in the body, how could this help out in radiation therapy, unless the protective protein attaches to all BUT the cancer cells? Otherwise, wouldn’t the cancer cells be protected too?


34 posted on 07/20/2009 5:18:18 AM PDT by AFreeBird
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To: wastedyears

The Israeli government would probably administer it to everyone, both Jewish and Pali, but the Palis would probably refuse it, believing it was some sort of sex hormone meant to destroy the morality of their youth. Then, when people started dying, they’d say that the sex hormone conspiracy theory was invented by Mossad to keep Palis from getting the radiation cure. And so it would go.


35 posted on 07/20/2009 5:32:07 AM PDT by Eleutheria5 (www.publishedauthors.net/benmaxwell/index.html. Donate to members.tripod.com/tva_israel/HOME.HTM)
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To: wastedyears

The Israeli government would probably administer it to everyone, both Jewish and Pali, but the Palis would probably refuse it, believing it was some sort of sex hormone meant to destroy the morality of their youth. Then, when people started dying, they’d say that the sex hormone conspiracy theory was invented by Mossad to keep Palis from getting the radiation cure. And so it would go.


36 posted on 07/20/2009 5:32:09 AM PDT by Eleutheria5 (www.publishedauthors.net/benmaxwell/index.html. Donate to members.tripod.com/tva_israel/HOME.HTM)
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To: Eleutheria5

Then they could roll back in and retake their land.


37 posted on 07/20/2009 9:14:53 AM PDT by wastedyears (The Tree is thirsty and the hogs are hungry.)
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To: Michel12

Israel should keep that for its own people, except for any other nations that may uncompromisingly support Israel. At this point in time, Israel does not get proper support from “allies.”


38 posted on 07/20/2009 3:47:03 PM PDT by familyop (cbt. engr. (cbt), NG, '89-' 96, Duncan Hunter or no-vote)
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To: AFreeBird

The effect of the protein would most likely be widespread and effect both normal and neoplastic cells. Even if you could prevent the protein from protecting clearly bad (pre-tumor) cells, the approach doesn’t seem like a good idea, since the whole function of apoptosis in response to DNA damage by radiation is to protect the body from having mutant and therefore potentially tumor-forming cells around. Then again, if the effect is transient maybe the mutant cells will eventually die off.


39 posted on 07/20/2009 4:23:29 PM PDT by ruination
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