Posted on 07/19/2009 5:11:19 PM PDT by Michel12
Medication that can protect humans against nuclear radiation has been developed by Jewish-American scientists in cooperation with a researcher and investors from Israel. The full story behind the dramatic discovery will be published in Yedioth Ahronoth's weekend edition.
The ground-breaking medication, developed by Professor Andrei Gudkov Chief Scientific Officer at Cleveland BioLabs - may have far-reaching implications on the balance of power in the world, as states capable of providing their citizens with protection against radiation will enjoy a significant strategic advantage vis-à-vis their rivals.
For Israel, the discovery marks a particularly dramatic development that could deeply affect the main issue on the defense establishment's agenda: Protection against a nuclear attack by Iran or against "dirty bomb" attacks by terror groups.
Gudkov's discovery may also have immense implications for cancer patients by enabling doctors to better protect patients against radiation. Should the new medication enable cancer patients to be treated with more powerful radiation, our ability to fight the disease could greatly improve.
The process that led up to the medical innovation dates back to 2003, when Professor Gudkov came up with the idea of using protein produced in bacteria found in the intestine to protect cells from radiation.
Gudkov recounted an experiment he held with two groups of mice.
"We exposed both groups to lethal radioactive radiation," he said. "All the mice in the control group died within a short period of time. A few days later, when I approached the cage with the mice that received the protein, I could see that they're ok, that they're alive. They survived. It's hard to describe the joy all of us felt. We realized that finally, after so many years and so many experiments and frustrations, we made a breakthrough that may save the lives of millions."
Prof. Gudkov published the findings of the protein experiment in Science, the world's leading scientific journal; however, the discovery of the medication was kept secret until now, while Gudkov and his associated waited for the results of two series of critical tests examining the medication's effectiveness and safety.
The first series of tests included experiments on more than 650 monkeys. Each test featured two groups of monkeys exposed to radiation, but only one group was given the medication. The radiation dosage was equal to the highest dosage sustained by humans as result of the Chernobyl mishap.
The experiment's results were dramatic: 70% of the monkeys that did not receive the cure died, while the ones that survived suffered from the various maladies associated with lethal nuclear radiation. However, the group that did receive the anti-radiation shot saw almost all monkeys survive, most of them without any side-effects. The tests showed that injecting the medication between 24 hours before the exposure to 72 hours following the exposure achieves similar results.
Another test on humans, who were given the drug without being exposed to radiation, showed that the medication does not have side-effects and is safe. Prof. Gudkov's company now needs to expand the safety tests, a process expected to be completed by mid-2010 via a shortened test track approved for bio-defense drugs. Should experiments continue at the current rate, the medication is estimated to be approved for use by the FDA within a year or two.
The company's subcontractor in Europe is already prepared to embark on mass production. Meanwhile, emergency regulations in Israel allow the government to purchase drugs on short notice, even if they are still in the process of being approved. Notably, the medication in question is not a vaccine, but rather, a preventative drug administered via one or several shots.
The medication works by suppressing the "suicide mechanism" of cells hit by radiation, while enabling them to recover from the radiation-induced damages that prompted them to activate the suicide mechanism in the first place.
Prof. Gudkov heads a group of Jewish-American scientists and has cooperated with an Israeli researcher and Israeli investors. A large part of the revolutionary medication's development process was funded by the US Defense and Health departments, which thus far earmarked $40 million to the project. About two weeks ago, the US Defense Department announced that in light of the successful tests, it will continue to fund the project.
The Israeli scientist involved in the research, Dr. Elena Feinstein, made Aliyah to Israel in 1985 and for many years served as a cancer researcher at the Weizmann Institute of Science. Dr. Feinstein met Prof. Gudkov while they worked together in Moscow and was among the founders of the company, serving as its deputy director for some time.
Today, Feinstein works for an Israel company engaged in cancer research and continues to cooperate with Gudkov. Referring to the innovative medication, she says: "Both its effectiveness and safety had been proven. It is stable, safe, and easy to inject."
Both Feinstein and Gudkov stress that the innovative drug does not provide 100% protection against radioactive damage. However, should the discovery announced by the scientists meet all the required tests and permits, it may change the 21st Century.
My money is on this being overblown hype.
A game changer for mostly politicians, as if they’d hand that out to citizens.
If this unnamed protein suppresses apoptosis, then recipients of the, what, vaccine, who have diagnosed or undiagnosed cancers are going to experience rapid metastasis.
It’s still quite an advancement, so this is should not discredit the discovery. But, it should give certain people pause.
If a nuclear bomb detonates on a city, I was always taught that it would be uninhabitable for hundreds of years. How is it that Hiroshima and Nagasaki are thriving cities today?
That was my first thought.
The drug developed by Professor Andrei Gudkov may affect the future balance of world powers, the paper said, and will offer cancer sufferers better protection as they undergo radiation treatment.
Now that may be a game changer,
in radiation therapy patients
NASA is going to want some for the Mars mission!!!
That's nothing.
We blew up over 1000 nukes just outside of Las Vegas.
I hope this is true for Israel’s sake..... I’ll keep watching
On the other hand, there is a lot of good science that comes from industry. Plus, university researchers have just as many conflicts of interest as those working in industry; probably more so.
This bears indirectly on that promise of God that the Jews would be a blessing to all of mankind.
Hmmm... Maybe it is a varient on this
http://www.pnas.org/content/101/8/2452.abstract
Acute injury to the intestinal mucosa is a major dose-limiting complication of abdominal radiation therapy. We studied the role of the transcription factor NF-κB in protection against radiation-induced apoptosis in the intestinal epithelium in vivo. We use mice in which NF-κB signaling through IκB-kinase (IKK)-β is selectively ablated in intestinal epithelial cells to show that failure to activate epithelial cell NF-κB in vivo results in a significant increase in radiation-induced epithelial cell apoptosis. Furthermore, bacterial lipopolysaccharide, which is normally a radioprotective agent, is radiosensitizing in IKKβ-deficient intestinal epithelial cells. Increased apoptosis in IKKβ-deficient intestinal epithelial cells was accompanied by increased expression and activation of the tumor suppressor p53 and decreased expression of antiapoptotic Bcl-2 family proteins. These results demonstrate the physiological importance of the NF-κB system in protection against radiation-induced death in the intestinal epithelium in vivo and identify IKKβ as a key molecular target for radioprotection in the intestine. Selective preactivation of NF-κB through IKKβ in intestinal epithelial cells could provide a therapeutic modality that allows higher doses of radiation to be tolerated during cancer radiotherapy.
“If a nuclear bomb detonates on a city, I was always taught” that it would be uninhabitable for hundreds of years. How is it that Hiroshima and Nagasaki are thriving cities today?”
We cleaned it up for them.
That was my initial thought as well. The “Cell Suicide Mechanism” is natures way of preventing damaged or abnormal cells from reproducing.
http://www.stormingmedia.us/42/4243/A424344.html
Abstract: The major goal of the program is identification of novel radioprotectants of Mycoplasma origin. The program consisted of two branches; screening of Mycoplasma strains for anti-apoptotic factors; and testing of predicted candidates for radioprotective activity. Both approaches were successfully implemented and yielded positive results. First, we have found and are currently characterizing a strong anti-apoptotic activity in the lysates of M. arginini. Second, an extremely potent radioprotectant, named CBLB601, structurally related to Mycoplasma lipopeptides was discovered. We have optimized CBLB601 administration regime for reaching maximal radioprotection as well as embarked upon characterization of its toxicological and pharmacological profiles. CBLB601 showed remarkable efficacy, being capable of protecting 100% of treated mice from supralethal 10Gy total body irradiation dose with evident rescuing lymphoid organs. Initial structure-function analysis of CBLB601 led to the understanding that radioprotection is conferred by stimulation of TLR2/TLR6 but not TLR2/TLR1 dimers.
And this patent application...
1) does the medication have to be introduced to the patient within the -24 to +72 hour time frame? Can it be introduced earlier and still be effective? If so, how much earlier?
2) wouldn't an enemy of Israel attempt to strike immediately knowing this miracle medication would be available in the near future?
Thank you for the explanation
For Israel, the discovery marks a particularly dramatic development that could deeply affect the main issue on the defense establishment's agenda: Protection against a nuclear attack by Iran or against "dirty bomb" attacks by terror groups.
As a believer, I agree with you!!
.............Now the only thing missing is a cure to combat the effects of the bomb blast. If somebody could develop such a thing, nuclear bombs could be rendered useless.............
“Now fellow survivors, this is the EIB network. If you can hear me, you are probably only under 50 feet of concrete debris!
Now, crawl out of there, and report immediately to your local Barack H. Omama National Medical Clinic (BHONMC.gov) for immediate treatment. However, we must warn you that if you have a bloody T shirt, or facial lesions, you will need to receive further diagnosis and treatment approval from the nearest doctor within 50 miles of your current position!
On MapQuest enter your position, and your intended destination!
BBBTTTZZZZZZZTTTTT! Oh sorry, the net is down!
Good luck, and have a nice life!
.............Now the only thing missing is a cure to combat the effects of the bomb blast. If somebody could develop such a thing, nuclear bombs could be rendered useless.............
“Now fellow survivors, this is the EIB network. If you can hear me, you are probably only under 50 feet of concrete debris!
Now, crawl out of there, and report immediately to your local Barack H. Omama National Medical Clinic (BHONMC.gov) for immediate treatment. However, we must warn you that if you have a bloody T shirt, or facial lesions, you will need to receive further diagnosis and treatment approval from the nearest doctor within 50 miles of your current position!
On MapQuest enter your position, and your intended destination!
BBBTTTZZZZZZZTTTTT! Oh sorry, the net is down!
Good luck, and have a nice life!
That particular promise of God that the Jews would be a blessing directly refers to the Birth of Christ who was born and raised as a practicing Jew.
The Blessing refers to the Word of God protected through the Old testament scribes and priests and the fulfillment by Christ in the new Testament which was foretold in the old testament.
Christ is THE blessing while the Jewish nation was the vessel that the blessing came through.
If youd like to be on or off, please FR mail me.
..................
Okay, help this layman out with this: If this protective protein attaches to all cells in the body, how could this help out in radiation therapy, unless the protective protein attaches to all BUT the cancer cells? Otherwise, wouldn’t the cancer cells be protected too?
The Israeli government would probably administer it to everyone, both Jewish and Pali, but the Palis would probably refuse it, believing it was some sort of sex hormone meant to destroy the morality of their youth. Then, when people started dying, they’d say that the sex hormone conspiracy theory was invented by Mossad to keep Palis from getting the radiation cure. And so it would go.
The Israeli government would probably administer it to everyone, both Jewish and Pali, but the Palis would probably refuse it, believing it was some sort of sex hormone meant to destroy the morality of their youth. Then, when people started dying, they’d say that the sex hormone conspiracy theory was invented by Mossad to keep Palis from getting the radiation cure. And so it would go.
Then they could roll back in and retake their land.
Israel should keep that for its own people, except for any other nations that may uncompromisingly support Israel. At this point in time, Israel does not get proper support from “allies.”
The effect of the protein would most likely be widespread and effect both normal and neoplastic cells. Even if you could prevent the protein from protecting clearly bad (pre-tumor) cells, the approach doesn’t seem like a good idea, since the whole function of apoptosis in response to DNA damage by radiation is to protect the body from having mutant and therefore potentially tumor-forming cells around. Then again, if the effect is transient maybe the mutant cells will eventually die off.
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