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Potential Alzheimer's, Parkinson's Cure Found In Century-old Drug
ScienceDaily ^ | Aug. 18, 2008

Posted on 07/09/2009 8:02:25 AM PDT by MetaThought

ScienceDaily (Aug. 18, 2008) — A new study conducted by researchers at Children's Hospital & Research Center Oakland shows that a century-old drug, methylene blue, may be able to slow or even cure Alzheimer's and Parkinson's disease. Used at a very low concentration – about the equivalent of a few raindrops in four Olympic-sized swimming pools of water – the drug slows cellular aging and enhances mitochondrial function, potentially allowing those with the diseases to live longer, healthier lives.

A paper on the methylene blue study, conducted by Hani Atamna, PhD, and a his team at Children's, was published in the March 2008 issue of the Federation of American Societies for Experimental Biology (FASEB) Journal. Dr. Atamna's research found that methylene blue can prevent or slow the decline of mitochondrial function, specifically an important enzyme called complex IV. Because mitochondria are the principal suppliers of energy to all animal and human cells, their healthy function is critical.

(Excerpt) Read more at sciencedaily.com ...


TOPICS: News/Current Events
KEYWORDS: alzheimers; methyleneblue; parkinsons; parkinsonsdisease
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The actual paper is at http://www.fasebj.org/cgi/content/abstract/22/3/703

I know of several people who are trying this stuff, and reporting good results.

1 posted on 07/09/2009 8:02:25 AM PDT by MetaThought
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To: MetaThought

The article said — A new study conducted by researchers at Children’s Hospital & Research Center Oakland shows that a century-old drug, methylene blue, may be able to slow or even cure Alzheimer’s and Parkinson’s disease.

Well, now..,. if I put methylene blue in my coffee, I should be doing *real good* then... LOL...


2 posted on 07/09/2009 8:05:03 AM PDT by Star Traveler (The God of Abraham, Isaac and Jacob is a Zionist and Jerusalem is the apple of His eye.)
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To: MetaThought

That’s great! I hate to say it, but there is so much money involved companies and organizations will probably try to cover it up.


3 posted on 07/09/2009 8:05:45 AM PDT by I Hate Obama (Don't Blame Me I Voted For Paris Hilton)
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To: justiceseeker93; freekitty

PING


4 posted on 07/09/2009 8:06:46 AM PDT by ExTexasRedhead
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To: MetaThought
Is this the same stuff I use in my fish tank to cure ick?
5 posted on 07/09/2009 8:07:06 AM PDT by DYngbld (I have read the back of the Book and we WIN!!!!)
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To: MetaThought

ARe they participating in a study, or is it available for anyone to try? I have a step father who is suffering from Alzheimers, and I am very interested in this. If you could give me any info you have I would appreciate it. Thanks


6 posted on 07/09/2009 8:07:15 AM PDT by ga medic
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To: MetaThought
a few raindrops in four Olympic-sized swimming pools of water

Are raindrops a different size than other water drops? And is this a homeopathic medicine?

If this works, the Embryonic Stem Cell people won't be happy.

7 posted on 07/09/2009 8:08:16 AM PDT by ClearCase_guy (I don't believe anything anyone says about anything anymore.)
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To: I Hate Obama

It would be hard to cover something up that’s cheap and easily available.

You should find this stuff at your neighborhood aquarium store.


8 posted on 07/09/2009 8:09:15 AM PDT by MetaThought
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To: DYngbld

LOL! I have childhood memories of trying to cure ick in my Mollies and Swordtails with methylene blue.

Lost a lot of Mollies, IIRC ;-)


9 posted on 07/09/2009 8:09:24 AM PDT by Blueflag (Res ipsa loquitur)
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To: DYngbld

>>> Is this the same stuff I use in my fish tank to cure ick?

It is a coloring dye used to stain micro-organisms on laboratory slides.

Very poisonous.


10 posted on 07/09/2009 8:10:11 AM PDT by Safrguns
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To: MetaThought

Unless they mix it with extract of infant, I don’t think that Michael J. Fox will be interested.


11 posted on 07/09/2009 8:10:48 AM PDT by Redcloak ("Oh, bother!" said Pooh, as he chambered his last round.)
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To: MetaThought

Used in a somewhat higher concentration - say, a couple of milliliters in a jug of cheap wine - an imbiber will find themselves pissing Kelly green the next morning. This principle was applied at my fraternity house every October for the incoming freshmen to general hilarity.


12 posted on 07/09/2009 8:10:55 AM PDT by RonF
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To: MetaThought

Really? Let’s give some to 0bama. He needs it for his speeches.


13 posted on 07/09/2009 8:12:57 AM PDT by I Hate Obama (Don't Blame Me I Voted For Paris Hilton)
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To: DYngbld

Believe so.

I was working in a really crappy part of Africa, possibly got malaria (got sick, not sure what), and they used this to knock it out, along with some other drugs.

Turns your pee blue and the whites of your eyes blue.

I looked like an extra from “Dune.”


14 posted on 07/09/2009 8:14:00 AM PDT by Jewbacca (The residents of Iroquois territory may not determine whether Jews may live in Jerusalem.)
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To: Safrguns
" Used at a very low concentration – about the equivalent of a few raindrops in four Olympic-sized swimming pools of water."

I don't know how they determine the dose for "people"?..

sw

15 posted on 07/09/2009 8:14:22 AM PDT by spectre (Spectre's wife ) (Who will lead us?)
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To: MetaThought

Isn’t methylene blue the dye we used to inject into the blood stream in cardiology research labs? I can’t remember for sure. (I would think I’ve got Alzheimers myself except that I’ve always been this way.)


16 posted on 07/09/2009 8:14:38 AM PDT by Savage Beast ("Liberalism" is a psychosis. Quos Deus vult perdere, prius dementat.)
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To: RonF

Correct. See my post 15. 14?


17 posted on 07/09/2009 8:15:24 AM PDT by Jewbacca (The residents of Iroquois territory may not determine whether Jews may live in Jerusalem.)
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To: Savage Beast

Put a couple CC’s of it in a coke and give to someone then stand by and watch as they urinate brilliant blue!!!


18 posted on 07/09/2009 8:18:27 AM PDT by Concho ( No Birth Certificate-No Census!)
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To: All

Methylene Blue is cheap and easily available at aquarium stores.

One thing that’s still unknown is the exact dosage.
Various people suggest dosages of 60mcg & 1mg
(1 drop of the aquarium solution = 1mg)

It should to be taken 3 times a day.


19 posted on 07/09/2009 8:19:28 AM PDT by MetaThought
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To: Savage Beast

>>> Isn’t methylene blue the dye we used to inject into the blood stream in cardiology research labs?

My source says no... because it doesn’t show up on xray.

(my brother-in-law is visiting and is with me now.. he is an eye surgeon.)


20 posted on 07/09/2009 8:22:16 AM PDT by Safrguns
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To: Safrguns

bttt


21 posted on 07/09/2009 8:23:42 AM PDT by ConservativeMan55
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To: Concho

>>> Put a couple CC’s of it in a coke and give to someone then stand by and watch as they urinate brilliant blue!!!

will also make them very sick


22 posted on 07/09/2009 8:23:43 AM PDT by Safrguns
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To: RonF

The Use of Methylene Blue, by I.P. Greene.


23 posted on 07/09/2009 8:24:48 AM PDT by patton (Obama has replaced "Res Publica" with "Quod licet Jovi non licet bovi.")
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To: Jewbacca

That kind of sounds like high doses of silver. I wonder if there is any connection because I have seen positive results in using colloidal silver for a few things that needed healing.


24 posted on 07/09/2009 8:28:31 AM PDT by outinyellowdogcountry
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To: MetaThought

Awesome. Thanks for posting this.


25 posted on 07/09/2009 8:29:25 AM PDT by mysterio
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To: MetaThought

“UK scientists have developed a drug which may halt the progression of Alzheimer’s disease.

Trials of the drug, known as Rember, in 321 patients showed an 81% difference in rate of mental decline compared with those not taking the treatment.

The Aberdeen University researchers said the drug targeted the build-up of a specific protein in the brain.

Alzheimer’s experts were optimistic about the results, but said larger trials were now needed. “ BBC News 28 July 2008

Presenting the results at the International Conference on Alzheimer’s Disease, Professor Claude Wischik said the drug may be on the market by 2012.

Fact is that this isn’t really news. The study you refer to is part if ongoing research. Time will tell. But as with all medicines, this will not be a panacea


26 posted on 07/09/2009 8:29:35 AM PDT by the long march
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To: Star Traveler

Blue sclera green pee -— you may scare the neighbors


27 posted on 07/09/2009 8:30:14 AM PDT by the long march
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To: I Hate Obama
Really? Let’s give some to 0bama. He needs it for his speeches.

Eh? Why do you think his lips are blue?

28 posted on 07/09/2009 8:33:33 AM PDT by null and void (We are now in day 170 of our national holiday from reality.)
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To: outinyellowdogcountry

I have no idea.

The blue pee went away in a couple of days; the blue eyes lasted a week or so.

It’s commonly used for malaria and other parasites.

I was sick as a dog (very high fever) and I believe the MB gave me a very sour stomach -— but that could have been the parasites.


29 posted on 07/09/2009 8:33:45 AM PDT by Jewbacca (The residents of Iroquois territory may not determine whether Jews may live in Jerusalem.)
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To: the long march

LOL..., I’ll be sure to keep the door closed...


30 posted on 07/09/2009 8:33:52 AM PDT by Star Traveler (The God of Abraham, Isaac and Jacob is a Zionist and Jerusalem is the apple of His eye.)
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To: Star Traveler
Well, now..,. if I put methylene blue in my coffee, I should be doing *real good* then... LOL...

Now, if I could only remember where the coffeepot is......

31 posted on 07/09/2009 8:34:18 AM PDT by exit82 (Sarah Palin is President No. 45. Get behind her, GOP, or get out of the way.)
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To: ClearCase_guy

The article says a few rain drops in a swim pool . I don’t know if that is what the nurtritionist study says BUT the research going in the UK is using the following dosages

“Patients with mild to moderate Alzheimer’s disease were given either 30, 60 or 100mg of the drug or a placebo.

The 60mg dose produced the most pronounced effect - over 50 weeks there was a seven-point difference on a scale used to measure severity of dementia” BBC News 28July 2008


32 posted on 07/09/2009 8:34:32 AM PDT by the long march
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To: patton

Excellent.


33 posted on 07/09/2009 8:35:02 AM PDT by null and void (We are now in day 170 of our national holiday from reality.)
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To: Safrguns

methhylene blue is NOT the same as methyl blue


34 posted on 07/09/2009 8:35:30 AM PDT by the long march
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To: MetaThought

Further along in the article it says: “But because high concentrations of methylene blue were known to damage the brain, no one thought to experiment with low concentrations.”

Who said, “It is the dose that makes the poison”? How are the mega dose lab rat testing scare mongering liberals going to handle this?


35 posted on 07/09/2009 8:35:35 AM PDT by FreedomNotSafety
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To: the long march; DJ MacWoW; Darksheare; Darkchylde
Blue sclera green pee -— you may scare the neighbors

Some neighbor are used to odd goings on...

36 posted on 07/09/2009 8:36:40 AM PDT by null and void (We are now in day 170 of our national holiday from reality.)
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To: the long march; All

I believe the theory is that the article mixed up mg and mcg.

The researchers might actually be referring to mcg.

Seeing good effects at 60mcg ...


37 posted on 07/09/2009 8:37:28 AM PDT by MetaThought
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To: Jewbacca

You are the winner. This was used as a standard treatment for malaria ( cost and effectiveness) until WWII when those treated in the PTO complained about those very side effects. It is making a come back as a treatment however because it is so very effective.


38 posted on 07/09/2009 8:38:32 AM PDT by the long march
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To: null and void; Darksheare

The cows don’t notice. Well except for cowdini who keeps escaping.


39 posted on 07/09/2009 8:38:45 AM PDT by DJ MacWoW (Make yourselves sheep and the wolves will eat you. Ben Franklin)
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To: Concho

Actual you pee green ( dye is blue your urine should be straw to yellow -— yellow and blue together make GREEN)


40 posted on 07/09/2009 8:39:38 AM PDT by the long march
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To: DJ MacWoW

I wonder why....


41 posted on 07/09/2009 8:40:21 AM PDT by null and void (We are now in day 170 of our national holiday from reality.)
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To: the long march
Blue sclera green pee -— you may scare the neighbors

Naw, it'll just go with all the rainbows and unicorns crapping skittles on their lawn since The One assumed power.

42 posted on 07/09/2009 8:41:17 AM PDT by OB1kNOb (It is impossible to convince someone of facts or truth if they don't want to believe it.)
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To: Safrguns

Methylene blue is used in endoscopic polypectomy as an adjunct to saline or epinephrine, and is used for injection into the submucosa around the polyp to be removed. This allows the submucosal tissue plane to be identified after the polyp is removed, which is useful in determining if more tissue needs to be removed, or if there has been a high risk for perforation. Methylene blue is also used as a dye in chromoendoscopy, and is sprayed onto the mucosa of the gastrointestinal tract in order to identify dysplasia, or pre-cancerous lesions. Intravenously injected methylene blue is readily released into the urine and thus can be used to test the urinary tract for leaks or fistulas.

In surgeries such as sentinel lymph node dissections, methylene blue can be used to visually trace the lymphatic drainage of pertinent tissues. Similarly, methylene blue is added to bone cement in orthopedic operations to provide easy discrimination between native bone and cement. Additionally, methylene blue accelerates the hardening of bone cement, increasing the speed at which bone cement can be effectively applied.

Guess your “source “ is wrong. Xray is NOT the only manner in which one uses a dye in medicine. In fact dyes are mostly not used for x-rays since those are looking at hard ( or hardening) masses


43 posted on 07/09/2009 8:44:07 AM PDT by the long march
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To: Safrguns

Not necessarily. while it is an MAOI most people will never ingest enough to trigger any of the sertonin toxcity.


44 posted on 07/09/2009 8:45:03 AM PDT by the long march
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To: RonF
an imbiber will find themselves pissing Kelly green the next morning

Not advisable when you're getting ready to take a piss test as part of your clearance in the Air Force.

45 posted on 07/09/2009 8:46:38 AM PDT by Tennessee_Bob (Save the Hispaniolan Solenodon!)
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To: MetaThought

The was from 2008. Anything more recent?


46 posted on 07/09/2009 8:47:37 AM PDT by nikos1121
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To: the long march

This was mid-1980s. Israeli equivalent of peace corp do-goodery in the hinderlands.

They used it with quinine and probably 3 other things; I known one was some sort of sulfa, as I could also smell sulfer when I sweated.

Of course, they weren’t sure what I had and basically just poisoned me just shy of dying to make sure they killed whatever slithered inside me.

Equatorial medicine at its best.


47 posted on 07/09/2009 8:47:41 AM PDT by Jewbacca (The residents of Iroquois territory may not determine whether Jews may live in Jerusalem.)
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To: MetaThought

Wow, what a break though, this is great news!


48 posted on 07/09/2009 8:48:17 AM PDT by Dustbunny ("Government does not solve problems; it subsidizes them. " Ronald Reagan)
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To: the long march

“Actual you pee green ( dye is blue your urine should be straw to yellow -— yellow and blue together make GREEN)”

I pissed blue, but I was also on IV liquids.

Perhaps it was blue-green.

You also sweat blue.


49 posted on 07/09/2009 8:50:28 AM PDT by Jewbacca (The residents of Iroquois territory may not determine whether Jews may live in Jerusalem.)
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To: I Hate Obama

Some of that happened in Canada when it was showed that Capscacin was shown to reduce swelling in islet cells in the pancreas, curing diabetes type one in rats.

That news, and both researchers, left the face of the earth somehow.

The worst thing that could happen to the health care economy is a cure for Type 1 and Type 2 diabetes. Cash cow.

Until recently, those islet cells were thought to be dead. It’s not turning out to be the case.


50 posted on 07/09/2009 8:51:44 AM PDT by RinaseaofDs
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