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Stem cells 'able to reverse symtoms of multiple sclerosis'
telegraph.co.uk ^ | 23 Apr 2009 | Kate Devlin

Posted on 06/10/2009 12:42:49 PM PDT by neverdem

Scientists have been able to reverse the symptoms of multiple sclerosis using stem cells from patients' own body fat.

Some have been left free from seizures and better able to walk after the treatment.

Researchers said that the results suggest that the "very simple" injection of their own cells can stimulate the regrowth of tissue damaged by the progression of the disease.

The preliminary findings add to the growing evidence that stem cells could be used to treat the crippling neurological disease, which affects about 85,000 people in Britain.

Last year experts suggested that stem cell therapy could be a "cure" for MS within the next 15 years.

Patients' symptoms were still improving up to a year after the treatment, the new study shows.

One, a 50-year-old man, who had suffered more than 600 painful seizures in the three years before treatment has not had a single one since the infusion of his own cells.

Another patient's ability to walk, run and even cycle are still improving 10 months after the therapy.

MS is caused by the destruction of myelin, a fatty protective sheath surrounding the body's central nervous system.

Sufferers typical experience fatigue, difficulty walking or speaking and pain and there is currently no known cure.

Dr Boris Minev, from the University of California, said: "All three patients in our study showed dramatic improvement in their condition.

"While obviously no conclusions in terms of therapeutic efficacy can be drawn from these reports, this first clinical use of fat stem cells for treatment of MS supports further investigations into this very simple and easily-implementable treatment methodology".

He added: "None of the presently available MS treatments selectively inhibit the immune attack against the nervous system, nor do they stimulate regeneration of previously damaged tissue. We've shown that [the] cells may fill..."

(Excerpt) Read more at telegraph.co.uk ...


TOPICS: Culture/Society; News/Current Events; Testing
KEYWORDS: adultstemcells; health; ms; multiplesclerosis; stemcells
Non-expanded adipose stromal vascular fraction cell therapy for multiple sclerosis

FReebie

1 posted on 06/10/2009 12:42:49 PM PDT by neverdem
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To: neverdem
"from patients' own body fat"

I wanted to emphasize that these weren't form embryonic stem cells.

2 posted on 06/10/2009 12:45:53 PM PDT by In veno, veritas (Please identify my Ad Hominem attacks. I should be debating ideas.)
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To: neverdem

It’s a good thing we didn’t divert significant amounts of funding into Embryonic Stem Cell Research. Oh, wait ...


3 posted on 06/10/2009 12:46:14 PM PDT by NonValueAdded ("I've conquered my goddam willpower." Don Marquis)
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To: neverdem

Rules for Lefty Journalists:

If a criminal politician is a Democrat, never print the (D), but always figure a way to work the word “Republican” into the story....

If an effective treatment uses Adult Stem Cells, never print the word “Adult”, but always try to work the word “Embryonic” into the story...


4 posted on 06/10/2009 12:46:21 PM PDT by gridlock (L'Etat, c'est Barack...)
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To: neverdem

This is another example how adult stem cells are solving the problems which is why embryonic stem research shouldn’t be allowed.


5 posted on 06/10/2009 12:47:58 PM PDT by lilylangtree (Veni, Vidi, Vici)
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To: gridlock

There is another tactic under developement where a sample of bone marrow is augmented/enhanced, the old bone marrow nuked, and the new marrow inserted.


6 posted on 06/10/2009 12:49:21 PM PDT by ak267
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To: lilylangtree

Not only are adult cells solving problems, but I have heard scary things about use of embryonic cells (outside of the ethical problems.)


7 posted on 06/10/2009 12:49:22 PM PDT by conservative cat (America, you have been PWNED!)
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To: neverdem

There’s a private outfit down in San Diego that does this. They have a Japanese partner...they use liposuction to extract bulk fat, then they purify the adipocytes, etc. and magnify them in some kind of MEM solution.

And then the therapeutic subFraction is re-injected back into the same person later, thereby avoiding compatibility problems.

No kids are harmed, and there are no teratoma-type complications of course.


8 posted on 06/10/2009 12:55:23 PM PDT by gaijin
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To: In veno, veritas
I wanted to emphasize that these weren't form embryonic stem cells.

Minor point. That will be glossed over. The spin in the near future is that it was a benefit from embryonic stem cell research.

9 posted on 06/10/2009 12:56:26 PM PDT by Always Right (Obama: more arrogant than Bill Clinton, more naive than Jimmy Carter, and more liberal than LBJ.)
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To: lilylangtree
This is another example how adult stem cells are solving the problems

Yes, that is the Politically Incorrect thing, and that is why they avoid it like the plague. They are committed that Embryonic Stem cells will cure everything when Adult Stem cells are proving to be the boon the Liberals sought.

Once Embryonic Stem cells were declared the de-facto politically correct thing to say; the MSM was committed and must obfuscate anything else on the matter.

The Truth will out.

10 posted on 06/10/2009 12:57:13 PM PDT by sr4402
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To: gaijin

Just visited the original article —there’s a HUGE error in it. The photo they feature shows a totipotent cell being extracted from a (probably 3 day old) EMBRYO.

That’s wrong.

This procedure doesn’t involve kids, or babies, or fertilized eggs, or anything like that —verrrrry deceptive.

Good post, but THAT PHOTO IS WRONG.


11 posted on 06/10/2009 12:58:40 PM PDT by gaijin
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To: neverdem

You CAN’T cure diseases without killing babies. The debate is OVER.


12 posted on 06/10/2009 12:59:37 PM PDT by Arthur McGowan
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To: Arthur McGowan

yes you can.........using adult stem cells....happens every day.


13 posted on 06/10/2009 1:01:35 PM PDT by tioga
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To: gaijin

A much better photo would feature some middle-aged fat guy (or woman), with some sucker thing, sucked into his abdomen, under a surgical cape, and he/she would be smiling, giving a thumbs-up.

I cannot BELIEVE that they made such a huge error by accident —no freaking way.

The original article is by a DISHONEST JOURNALIST.

What in hell is a fertilized egg doing in the article? If used it should say, “This l’il thang here makes a PERSON, or IS a person, who earns a driver’s licence, then gets fat 40 years later, and then undergoes LIPOSUCTION”.

IDIOTS.


14 posted on 06/10/2009 1:02:24 PM PDT by gaijin
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To: neverdem

Interesting bookmark.


15 posted on 06/10/2009 1:03:47 PM PDT by LuxMaker (The Constitution is a mere thing of wax in the hands of the judiciary, Thomas J 1819)
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To: tioga

I think he was using parody —like when there’s a story about a gun death in a country that bans guns, and we all pile on saying, “That’s impossible, it must have been a knife..!!”


16 posted on 06/10/2009 1:03:59 PM PDT by gaijin
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To: gaijin

the /sarcasm tag works great.......I hate to let those things stand for the lurkers to get confused.


17 posted on 06/10/2009 1:05:44 PM PDT by tioga
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To: In veno, veritas

Have embryonic stem cells done anything YET, compared to the “miracles” of adult stem cells?


18 posted on 06/10/2009 1:06:35 PM PDT by NoGrayZone (All aboard the 1st Annual Free Republic National Tea Party Convention 9/10-9/12. Be there!!!)
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To: tioga

Arthur McGowan was not being serious. He was satirizing the left.


19 posted on 06/10/2009 1:06:37 PM PDT by LuxMaker (The Constitution is a mere thing of wax in the hands of the judiciary, Thomas J 1819)
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To: NoGrayZone

Yes, lined the pockets of the abortion doctors.


20 posted on 06/10/2009 1:07:58 PM PDT by LuxMaker (The Constitution is a mere thing of wax in the hands of the judiciary, Thomas J 1819)
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To: Arthur McGowan
"You CAN’T cure diseases be a humanist without killing babies." They MUST die.
21 posted on 06/10/2009 1:09:53 PM PDT by NoGrayZone (All aboard the 1st Annual Free Republic National Tea Party Convention 9/10-9/12. Be there!!!)
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To: tioga
Um, you didn't get the sarcasm there?
22 posted on 06/10/2009 1:11:37 PM PDT by NoGrayZone (All aboard the 1st Annual Free Republic National Tea Party Convention 9/10-9/12. Be there!!!)
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To: LuxMaker

Ooooo, most excellent reply!


23 posted on 06/10/2009 1:12:34 PM PDT by NoGrayZone (All aboard the 1st Annual Free Republic National Tea Party Convention 9/10-9/12. Be there!!!)
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To: NoGrayZone
Have embryonic stem cells done anything YET
It has generated lots of taxpayer dollars for no good reason.
24 posted on 06/10/2009 1:14:48 PM PDT by FlashBack ('0'bama: "Katrina on a Global Level")
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To: neverdem

Big Bump!


25 posted on 06/10/2009 1:16:34 PM PDT by AmericanVictory (Should we be more like them or they more like we used to be?)
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To: neverdem; cgk; rdb3

You’ll have to donate some of your fat rdb3!


26 posted on 06/10/2009 1:21:14 PM PDT by Incorrigible (If I lead, follow me; If I pause, push me; If I retreat, kill me.)
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To: lilylangtree

One would think that if it may help in any manner, all research should be allowed.


27 posted on 06/10/2009 1:24:41 PM PDT by stuartcr (Everything happens as God wants it to...otherwise, things would be different.)
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To: NoGrayZone
When they were discussing the issue, scientist didn't plan on any achievements from embryonic stem cells for a number of years. In the meantime, I think there is general agreement that embryonic stem cells have become obsolete.
28 posted on 06/10/2009 1:43:58 PM PDT by In veno, veritas (Please identify my Ad Hominem attacks. I should be debating ideas.)
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To: In veno, veritas
"In the meantime, I think there is general agreement that embryonic stem cells have become obsolete."

If that were true, why hasn't it stopped?

29 posted on 06/10/2009 1:48:38 PM PDT by NoGrayZone (All aboard the 1st Annual Free Republic National Tea Party Convention 9/10-9/12. Be there!!!)
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To: Incorrigible
You’ll have to donate some of your fat rdb3!

I'm not fat...

Okay, I'll admit it. My wife did it. It was good chicken, too. Then the gumbo. So what can I do?

Amazing << Hear this. Feel this, and tell me that this isn't music.

Oh, dear...


30 posted on 06/10/2009 2:30:41 PM PDT by rdb3 (The mouth is the exhaust pipe of the heart.)
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To: NoGrayZone
I would say that there are two reasons: first a general agreement (which is what I think exists) is not absolute; second, there is still money flowing to embryonic research.
31 posted on 06/10/2009 2:58:52 PM PDT by In veno, veritas (Please identify my Ad Hominem attacks. I should be debating ideas.)
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To: In veno, veritas

I knew there was a reason for me to hold off on that low calorie diet. (I have MS)


32 posted on 06/10/2009 3:28:56 PM PDT by lastchance (Hug your babies.)
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To: neverdem

Notice this little sleight of hand or in this case words:

“Meanwhile scientists are claiming a major breakthrough in generating safer stem cells from adult cells.

Scientists usually use a virus to make the switch but this makes the resulting stem cells incredibly dangerous for use in humans as they can cause cancer.”

Safer cells from adult stem cells? Resulting stem cells?
Two different things combined to confuse adult and embryonic cells in a typically dishonest effort.


33 posted on 06/10/2009 3:39:14 PM PDT by count-your-change (You don't have be brilliant, not being stupid is enough.)
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To: gaijin
The original article is by a DISHONEST JOURNALIST.

That's not necessarily so, IMHO. I believe editors call the shots on the title and how they decorate stories with pictures, illustrations, etc. I see that with the same syndicated column having different titles at various sources.

34 posted on 06/10/2009 4:08:35 PM PDT by neverdem (Xin loi minh oi)
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To: tioga

You don’t have much of a sense of humor, do you?


35 posted on 06/10/2009 5:14:14 PM PDT by Arthur McGowan
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To: Coleus; Peach; airborne; Asphalt; Dr. Scarpetta; I'm ALL Right!; StAnDeliver; ovrtaxt; ...
Stem cell special!

The miracle stem cell cures made in Britain (Stem cell jingoism for the biologically ignorant!)

Patients' own stem cells to be used to patch up holes in bones

Protein in stem cells 'linked to cancer'

FReepmail me if you want on or off my health and science ping list.

36 posted on 06/10/2009 5:50:34 PM PDT by neverdem (Xin loi minh oi)
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To: neverdem

ES stem cells and autologous stem cells are the same in the same manner that lighting and the lightning but are:

It’s like calling applying the term truck to a smart car. In fact, it’s even more bizarre an error, as one is seen as completely innocuous, and the other goes to the core of where life begins, and provokes a very emotional reaction from all kids of people.

I have not really made up my mind, as I work in this kind of regenerative therapy, but the difference is just completely huge.


37 posted on 06/10/2009 5:51:14 PM PDT by gaijin
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To: NoGrayZone
Have embryonic stem cells done anything YET, compared to the “miracles” of adult stem cells?

Why yes. They have made the proponents of fetal stem cell extraction from abortions feel fuzzy all over.
38 posted on 06/10/2009 5:57:32 PM PDT by Liberty Valance (Keep a simple manner for a happy life :o)
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To: NonValueAdded

as well as cut funding to the only stem cell treatment that works...adult stem cells.


39 posted on 06/10/2009 5:59:11 PM PDT by Scotswife
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To: count-your-change
Scientists usually use a virus to make the switch but this makes the resulting stem cells incredibly dangerous for use in humans as they can cause cancer.”

Safer cells from adult stem cells? Resulting stem cells? Two different things combined to confuse adult and embryonic cells in a typically dishonest effort

Look Ma, no virions.

Generation of Human Induced Pluripotent Stem Cells by Direct Delivery of Reprogramming Proteins

They used four reprogramming proteins (Oct4, Sox2, Klf4, and c-Myc) fused with a cell-penetrating peptide (CPP). If you check the articles you find linked along the keyword ipsc, you'll find one linked to the original article from Public Library of Medicine. No virus there either. IIRC, I posted an article about it within the last year.

40 posted on 06/10/2009 6:25:07 PM PDT by neverdem (Xin loi minh oi)
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To: Coleus; nickcarraway; narses; Mr. Silverback; Canticle_of_Deborah; TenthAmendmentChampion; ...
Pro-Life PING

Please FreepMail me if you want on or off my Pro-Life Ping List.

41 posted on 06/10/2009 6:39:02 PM PDT by cpforlife.org (A Catholic Respect Life Curriculum is available FREE at KnightsForLife.org)
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To: neverdem
Thanks Doc!

The LIN28 protein article was especially interesting, the ingredient for cure and destruction in one little molecule. Cancer and stem cells.....both fast growing cells, one with determined growth and the other out of control growth.
42 posted on 06/10/2009 9:10:18 PM PDT by BIGLOOK (Government needs a Keelhauling now and then.)
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To: neverdem; Coleus

They never say “adult” stem cells in these headlines, do they?


43 posted on 06/10/2009 9:32:15 PM PDT by Salvation (With God all things are possible.)
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To: neverdem; Joya

Joya ping


44 posted on 06/10/2009 9:32:34 PM PDT by Quix (POL Ldrs quotes fm1900 2 presnt: http://www.freerepublic.com/focus/religion/2130557/posts?page=81#81)
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To: lastchance
I knew there was a reason for me to hold off on that low calorie diet. (I have MS)

Me too ... since my left leg stopped working, I've been unable to run anymore, or bike. I hope the fat that accumulates before this treatment becomes mainstream can all be taken out and used for the treatment! Heck scratch that ... I'd be happy to get back to running and biking once the treatment kicks in, and lose it the old-fashioned way.

45 posted on 06/10/2009 11:05:45 PM PDT by lkco
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To: Salvation; Coleus; Peach; airborne; Asphalt; Dr. Scarpetta; I'm ALL Right!; StAnDeliver; ovrtaxt; ..
They never say “adult” stem cells in these headlines, do they?

Never say never in medicine. IIRC, I got 142 hits on YahooNews with "adult stem cells" with the quotation marks. Granted, most were news releases for banking umbilical cord blood. The link was in the first ten hits. I wonder if those umbilical cord blood stem cells are as primitive as a fertilized egg, i.e. a zygote, or the pair after the first mitosis.

When Stem Cell Research Gets Personal (Part 2) Interview With Bioethicist on Umbilical Cord Cell Banking

If the couple cannot afford it, they could consider putting some “friendly pressure” on their health insurance company to cover, at least, some of the cost. I think that it is important to get health insurance companies to understand that their investment in umbilical cord blood stem cell storage is to their financial advantage in the long run. Why? Because, as more and more cures come about in this field, on average, more and more of their clients would benefit from them -- say, for instance, an injured teenager whose cord cells were saved, and who will now heal better and faster because of them, thus reducing his hospital stay and treatment sessions, thus reducing health care insurance costs.

They have "Stem Cells for Dummies."

What is a Stem Cell’s Potency?

A stem cell’s “potency” refers to its capacity for differentiation, that is, for developing into particular kinds of human cells, e.g. liver, kidney, blood, etc. Different types of stem cells have different scopes to their potency: e.g., totipotent, pluripotent, multipotent or unipotent. A totipotent cell is capable of differentiating into every tissue in the human body, including extra-embryonic support tissues necessary for human gestation (e.g., placenta, umbilical cord, amniotic sac); a single-celled embryo, also called a zygote, possesses the capacity of totipotency; also, the individual cells of an embryo’s body, called blastomeres, in the first few days of the embryo’s life are totipotent; if a blastomere splits off from the embryo’s body, it has the capacity for complete human development, which is how we get identical twins. A pluripotent cell is capable of differentiating into almost all the tissues of the human body, but not the extra-embryonic support tissues; embryonic stem cells are pluripotent. Stem cells can also be multipotent (capable of differentiating into the cells of a cell group type, e.g., blood cells) and unipotent (unable to differentiate into any other cell type than itself).

What are the Differences between Embryonic and Adult Stem Cells?

Embryonic stem cells (ESCs) are undifferentiated, self-renewing, pluripotent cells. They are harvested from the bodies of embryos at approximately day five of human development. At day five the embryo’s body takes the shape of a hollow sphere (the embryo at this time is called a “blastocyst”). The blastocyst has an outer cell layer and an inner cell mass (picture a basketball with a small group of marbles clumped together on the inside). The cells of the inner cell mass will eventually differentiate into the varied tissues of the person’s body; and the outer cell layer will develop into the placenta and other support tissues. But it is important to understand that at this point, both the outer cell layer and inner cell mass constitute the embryo’s body. The inner cell mass can be understood to be the embryo’s internal organs. These cells are what we call embryonic stem cells and have the capacity of pluripotency; they are coveted by ESC researchers precisely because of their pluripotency. Just as harvesting all the internal organs of an adult would kill the adult, harvesting the stem cells of an embryo kills the embryo.

Adult stem cells (ASCs) also have the capacities of self-proliferation and differentiation, but are not derived from the bodies of embryos. They are ‘adult’ not because they’re found only in adults, but because the tissue in which they’re found is differentiated tissue (as opposed to the undifferentiated tissue of an embryo’s body). Thus ASCs can be found in newborn tissue. In fact, some of the most clinically valuable ASCs are found in umbilical cord blood. Although some ASCs have been found with the capacity of pluripotency, most are only capable of differentiating into the tissue type or related group type of the tissue in which they’re found.

Thank you, NYer!

46 posted on 06/10/2009 11:09:31 PM PDT by neverdem (Xin loi minh oi)
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To: lkco

Somedays it is as if my entire body is possessed by a petulant three year old. Do you want to go for a walk? NO!! Do you want to play a game? No!! Do you want to help me do this? NO!!. Fine, I guess we will just lie down and take a nap till you can learn to behave.


47 posted on 06/11/2009 9:35:31 AM PDT by lastchance (Hug your babies.)
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