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Study: No link between measles vaccine and autism
AP via YAHOO! ^ | 9-3-08 | LAURAN NEERGAARD

Posted on 09/03/2008 5:38:58 PM PDT by Pharmboy

New research further debunks any link between measles vaccine and autism, work that comes as the nation is experiencing a surge in measles cases fueled by children left unvaccinated.

Years of research with the measles, mumps and rubella vaccine, better known as MMR, have concluded that it doesn't cause autism. Still, some parents' fears persist, in part because of one 1998 British study that linked the vaccine with a subgroup of autistic children who also have serious gastrointestinal problems. That study reported that measles virus was lingering in the children's bowels.

Only now have researchers rigorously retested that finding, taking samples of youngsters' intestines to hunt for signs of virus with the most modern genetic technology. There is no evidence that MMR plays any role, the international team — which included researchers who first raised the issue — reported Wednesday.

"Although in fact there was evidence that this vaccine was safe in the bulk of the population, it had not been previously assessed with respect to kids with autism and GI complaints," said Dr. W. Ian Lipkin of Columbia University College of Physicians and Surgeons, who led the work published in PLoS One, the online journal of the Public Library of Science.

"We are confident there is no link between MMR and autism," Lipkin said.

Added co-author Dr. Larry Pickering of the Centers for Disease Control and Prevention: "I feel very certain that it is a safe vaccine."

(Excerpt) Read more at news.yahoo.com ...


TOPICS: Culture/Society; Extended News; News/Current Events
KEYWORDS: autism; evidencenotrumor; health; healthcare; measles; medicine; vaccines
Don Imus, call your office.
1 posted on 09/03/2008 5:39:01 PM PDT by Pharmboy
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To: neverdem; NonValueAdded; Coleus; blam; SunkenCiv; Clemenza; weegee; wagglebee; sinkspur; Eschoir; ..

Health ping...


2 posted on 09/03/2008 5:40:57 PM PDT by Pharmboy (Democrats lie because they must.)
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To: Pharmboy

Now you’ve done it! The anti-vaccine, anti-virus, whackos will be out in force.


3 posted on 09/03/2008 5:46:13 PM PDT by count-your-change (you don't have to be brilliant, not being stupid is enough.)
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To: count-your-change

Aren’t they all at the Ron Paul convention??


4 posted on 09/03/2008 5:48:27 PM PDT by Pharmboy (Democrats lie because they must.)
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To: Pharmboy

OK, what is Sarah Palin accused of doing this time?


5 posted on 09/03/2008 6:00:24 PM PDT by crazyhorse691 (McCain will screw the conservatives, but, Obama will screw the whole country.)
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To: Pharmboy

No,
Who funded the study?


6 posted on 09/03/2008 6:01:47 PM PDT by porter_knorr
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To: Pharmboy

Maybe a Mercola bash.


7 posted on 09/03/2008 6:06:24 PM PDT by count-your-change (you don't have to be brilliant, not being stupid is enough.)
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To: porter_knorr
Added co-author Dr. Larry Pickering of the Centers for Disease Control and Prevention: "I feel very certain that it is a safe vaccine."

CDC folks cannot take any outside money--from you, from me, or from Merck.

8 posted on 09/03/2008 6:08:05 PM PDT by Pharmboy (Democrats lie because they must.)
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To: Pharmboy

Mmm hmmm, and Dr. W. Ian Lipkin who specializes in immunology - no bias there?


9 posted on 09/03/2008 6:11:55 PM PDT by porter_knorr
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To: Pharmboy

it’s almost pointless to bring it up. The Trail Lawyers created the argument and the conspiracy theorists on both sides take off with it because it ‘seems’ like it might be true.

Dalkon Shield. Breast Implants. Vaccines. Just add it to the list of multi-billion dollar deep pockets trial lawyers need to keep their industry flush.


10 posted on 09/03/2008 6:16:01 PM PDT by bpjam (Obama is Black. Stop Asking Questions, Dammit!!!)
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To: porter_knorr
Mmm hmmm, and Dr. W. Ian Lipkin who specializes in immunology - no bias there?

Please explain more. It's very hard to follow your logic. Yes--he's an immunologist. Are you implying that immunologists are incapable of being unbiased scientists?

11 posted on 09/03/2008 6:20:45 PM PDT by Pharmboy (Democrats lie because they must.)
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To: Pharmboy

thanks, bfl


12 posted on 09/03/2008 6:26:59 PM PDT by neverdem (I'm praying for a Divine Intervention.)
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To: Pharmboy

I’d like to know where most of his funding comes from.
No, with his biography, I don’t believe he’s unbiased.


13 posted on 09/03/2008 6:33:24 PM PDT by porter_knorr
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To: porter_knorr
Here's his bio. You are showing more ignorance with each post. You are making accusations about a dedicated, highly accomplished scientist. I'm afraid it is YOU who is biased (and you may not be a total idiot, but you sure sound like one).

Department of Epidemiology, Columbia University

Ian Lipkin M.D. Professor

wil2001@columbia.edu

Telephone: 342-9033
Fax: 851-5395

Research interests

Background: W. Ian Lipkin, MD, is Professor of Epidemiology in the Mailman School of Public Health, and Director of both the Laboratory for Immunopathogenesis and Infectious Diseases, and the Center for Developmental Neuroscience. Through June 2002 Dr. Lipkin also holds academic positions at University of California Irvine where he is the Louise Turner Arnold Chair of Neuroscience, Director of the Emerging Diseases Laboratory and Professor in the Departments of Neurology, Anatomy and Neurobiology, and Microbiology and Molecular Genetics. He is internationally recognized as an authority on the use of molecular biological methods for pathogen discovery and the role of immune and microbial factors in neurologic and neuropsychiatric diseases.

Dr. Lipkin received a BA from Sarah Lawrence College in 1974, where he studied cultural anthropology, philosophy, and literature; and an MD from Rush Medical College in 1978. His postgraduate training included Clerkship at the Queen Square Institute of Neurology in London, UK (1977-78); Internship in Medicine at the University of Pittsburgh (1978-79); Residency in Internal Medicine at the University of Washington (1979-81), Residency in Neurology at the University of California, San Francisco (UCSF, 1981-84), and Fellowship in Neurovirology and Molecular Neurobiology at The Scripps Research Institute in La Jolla (TSRI, 1984-1990). His honors include National Multiple Sclerosis Society Postdoctoral Fellowship, 1984-1987, Clinical Investigator Development Award, National Institutes of Health, National Institute of Neurological and Communicative Disorders and Stroke, 1987-1992, NARSAD Young Investigator, 1991, Pew Scholar, 1991, Visiting Professor, Japanese Human Science Foundation, 1999, Visiting Bruenn Professor, Columbia College of Physicians and Surgeons, 2000, Louise Turner Arnold Chair in the Neurosciences, 2000, Foundation Lecturer, American Society of Microbiology, 2001, Ellison Medical Foundation Senior Scholar in Global Infectious Diseases, 2001.

While a Resident in Neurology, Dr. Lipkin established the first clinic for investigating neurologic manifestations of HIV infection. In 1983, he identified AIDS-associated inflammatory neuropathy and demonstrated that this crippling syndrome could be treated with plasmapheresis. In 1988 as a fellow with Dr. Michael Oldstone at TSRI he demonstrated that early life viral infection can cause behavioral and neurotransmitter disturbances without obvious evidence of brain infection or injury. The observation that cryptic infection can influence brain function is increasingly recognized as important in the context of neuropsychiatric diseases such as autism and schizophrenia; and it may also play a role in neurodegenerative disorders. To address such questions, Dr. Lipkin created molecular methods for rapidly detecting unknown viruses in clinical materials. The first application of these methods resulted in identification of Borna disease virus, a new type of virus that had eluded classical methods for virus purification. Since isolating the first genes of this virus in 1990, Dr. Lipkin cloned its genome and defined its replication strategy and the molecular basis for neurotropism and behavioral syndromes associated with acute and persistent brain infection. An international multi-center program coordinated by Dr. Lipkin is assessing the role of Borna disease virus in human neuropsychiatric diseases using methods patented by Lipkin, Briese and colleagues. Dr. Lipkin is the leader of the team that established the method of domain specific differential display and subsequently identified the West Nile virus in the brains of encephalitis victims in New York State in the fall of 1999.

14 posted on 09/03/2008 6:49:50 PM PDT by Pharmboy (Democrats lie because they must.)
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To: Pharmboy

Your personal attacks do nothing for your argument.


15 posted on 09/03/2008 6:59:19 PM PDT by porter_knorr
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To: porter_knorr
I did not attack you. You have some nerve to accuse this guy of bias with NOTHING to back it up. I said you may NOT be an idiot, but you sure sound like one.

YOU were the one who started with personal attacks, and if you cannot make any points based on data, than shut up and do not make baseless claims. You sound like a liberal.

16 posted on 09/03/2008 7:07:10 PM PDT by Pharmboy (Democrats lie because they must.)
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To: porter_knorr

I’d like to know where your funding comes from and what bias’ you have.
Who are you relying on for information and on what do you base your comments?


17 posted on 09/03/2008 7:11:50 PM PDT by count-your-change (you don't have to be brilliant, not being stupid is enough.)
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To: Pharmboy

Little hot under the collar for someone disagreeing with you how come? I thought we could disagree??

I work in the field with medical research, and if you don’t know there are biases, and studies that have a desired outcome, perhaps it’s not I that is ignorant.

No, surprisingly the liberals are normally the one who think we need the government to take care of us and our children. I’m shocked that you think otherwise.

Now, you have insulted me at least three times, I didn’t insult you once I merely disagreed with you.


18 posted on 09/03/2008 7:14:23 PM PDT by porter_knorr
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To: porter_knorr
I will type slowly so maybe you'll get it. You didn't disagree with me or anyone else; you accused a renowned scientist of bias--twice--without furnishing any proof or even mild backup. That's just what libs do. I was merely pointing out that anyone who does that is ignorant or biased. If the shoe fits...
19 posted on 09/03/2008 7:19:53 PM PDT by Pharmboy (Democrats lie because they must.)
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To: Pharmboy

Does putting people down continually usually make you more right? Or do people just tire of your insults

I didn’t accuse HIM of bias, I asked Where does his funding come from - it’s a legitimate question. For you to be so upset makes me wonder why?


20 posted on 09/03/2008 7:24:05 PM PDT by porter_knorr
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To: porter_knorr
From your last post:

I didn’t accuse HIM of bias,

From your post 13:

No, with his biography, I don’t believe he’s unbiased.

You seem confused. If you're in the health field, God help us all...have a good night and good bye.

21 posted on 09/03/2008 7:29:11 PM PDT by Pharmboy (Democrats lie because they must.)
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Comment #22 Removed by Moderator

To: Pharmboy

I don’t believe he is unbiased.
I would prefer to know more about his funding.

You don’t have any answers except to hurl insults.
Good night yourself.


23 posted on 09/03/2008 7:37:58 PM PDT by porter_knorr
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To: Pharmboy

I listened to the testimony given before congress, and while I cannot address the safety of vaccination, what I did note was a disturbing consensus: that even if there is a problem, vaccination is far better than not vaccinating.

That is, a willingness to play a numbers game. A acceptable risk to a minority, to protect the majority. And that I find disturbing.

This is because, by general agreement, if the Measles/Mumps/Rubella shot is given as three different injections, the odds of harm are thought to be much less than as a combined injection. This is because it is far less traumatic to the immune system, an astoundingly complex system, to have to respond to a single infection instead of three at the same time.

But in this testimony, it was admitted that it was extremely difficult to get even a single vaccination to all children, and the public health system cannot imagine how it could successfully administer three such injections, without missing a huge number of children.

Ironically, the end result may be a mirror image of our school systems. That is, like parents who home school or send their children to private schools, parents with concern about MMR vaccinations will arrange with their private doctor or as a group to have them given as separate vaccinations over a period of time. But the vast majority will still have their children in public school, and get the MMR.

I will leave whether MMR presents a tangible risk of autism to be discerned in the future, but I note that the Japanese have just discovered that by discontinuing a vaccination for tuberculosis, they reduced their high incidence of diabetes by 50%:

http://myturl.com/0pceJ

There is still a very great deal we do not know about the human immune system, and how even a lack of disease might be more harmful to us than the disease itself.


24 posted on 09/03/2008 7:40:17 PM PDT by yefragetuwrabrumuy
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Comment #25 Removed by Moderator

Comment #26 Removed by Moderator

To: Morgana

Which disease are you speaking of? (the one that’s worse than the cure)

And I bet there’s a whole lot of parents with autistic children that would disagree with you. But you don’t make comments like that without hoping to stir the pot a bit.


27 posted on 09/03/2008 7:51:46 PM PDT by porter_knorr
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To: yefragetuwrabrumuy
Would that diabetes t.b. study citation be from a certain Dr. Classen, a family medicine M.D.?
28 posted on 09/03/2008 9:00:28 PM PDT by count-your-change (you don't have to be brilliant, not being stupid is enough.)
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To: Pharmboy

Thanks PB.


29 posted on 09/03/2008 11:02:44 PM PDT by SunkenCiv (https://secure.freerepublic.com/donate/_______Profile hasn't been updated since Friday, May 30, 2008)
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Comment #30 Removed by Moderator

To: Morgana

Yes—there are indeed terrible twos; but the issues with autism are real (but there is NO evidence that vaccines are the culprits, and much evidence AGAINST any association). We have more autism today than 20 years ago for one simple reason: we have broadened the diagnostic factors. We now have “autistic spectrum disorder” as a diagnosis, whereas before we called these more mildly affected kids “emotionally disturbed.”


31 posted on 09/04/2008 7:38:52 AM PDT by Pharmboy (Democrats lie because they must.)
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To: count-your-change

I was unaware of any controversy surrounding Dr. Classen, but I note the source I used cited him. Since there is a problem, I would withdraw that supporting point from my original argument, but my basic point remains: that we will probably move to a situation where the majority of parents will accept whatever risk is inherent in vaccination, and the minority will be able to get three separate vaccinations for their children.

While this doesn’t address whether or not there are risks associated with a multiple disease vaccination, it does provide some alternative to parents who are disturbed by the possibility, yet still accomplishes the goal of the most students being vaccinated, even if a tiny minority are harmed in any way.

This should not be discouraged by the health authorities, as their mission is to get universal vaccination, which is not dependent on how that is done.

I would note that there are some individuals who are firm believers that the process of universality is more important than the goal. This actually works against the mission of universal vaccination.

They hold similar beliefs that having socialized medicine as a system is far more important than actually providing quality health care. This is an inherent flaw in their belief system that tends to inhibit any mission oriented goal they attempt. In this case, it is most definitely the ends that matter, not the means to those ends.


32 posted on 09/04/2008 8:21:36 AM PDT by yefragetuwrabrumuy
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To: yefragetuwrabrumuy
Dr. Classen, as a web search reveals, worked for NIH for a time but has never actually practiced medicine. He started his own company that has received some patents but has done little else.
Classen’s studies are the only ones that support his contention that the timing of immunization has anything to do with diabetes. A large number of studies show the opposite and some are cited here:

“Current Evidence - No Link Between Vaccination and Type 1 Diabetes Mellitus
Web site: December 1999
Prescriber Update No.19:25-27

Medsafe Editorial Team

On the basis of a postulated infectious mechanism for the development of type 1 (insulin dependent) diabetes mellitus, several studies have investigated the possibility of an association with vaccination. To date support has not been obtained for associations between type 1 diabetes mellitus and BCG, MMR, pertussis or Haemophilus influenzae type b vaccines.

Postulated autoimmune mechanism for suggested link with vaccines
No difference in rate of BCG vaccination between cases and controls
No association with MMR, pertussis or H. Influenzae type b
References

Postulated autoimmune mechanism for suggested link with vaccines
Several researchers have postulated that type 1 (insulin dependent) diabetes mellitus may develop secondary to an abnormal immune response to some viral infections. The possibility that childhood vaccination may also be associated either negatively or positively has also been considered. The steady increase in the incidence of type 1 diabetes mellitus in children in several countries1,2 has lent some credence to the possibility of a positive association. Studies in diabetic mice have found that Bacille Calmette-Guérin (BCG) vaccine has interrupted the development of diabetes mellitus.3 However, most studies in humans published to date have not supported the postulated negative association with BCG vaccine or the positive association with other vaccines, but rather have found evidence for no association.

No difference in rate of BCG vaccination between cases and controls
Classen and Classen4 studied the incidence of diabetes and the immunisation schedule in a number of developed countries and found that the countries with the lowest rates of diabetes were those with pertussis vaccine in the vaccination programme and in which infants received BCG vaccine before 2 months of age. However, 2 of the areas where neither pertussis nor BCG were part of the schedule had among the lowest annual incidence rates (Lazio and Lombardi regions of Italy with 6.5 and 6.8 cases/100,000, respectively). Further, the study did not include Finland which has the highest incidence of type 1 diabetes in children under 15 years (35.3/100,000 for 1987-89)5 and where BCG has been given at birth for several decades.1

A study6 conducted in Québec found no difference in the overall rate of BCG vaccination in children with type 1 diabetes mellitus compared with the control group in either of 2 case series. However, in one case series, BCG vaccination did appear to delay the onset of diabetes (12.2 ± 3.5 years for vaccinated compared with 9.2 ± 4.5 years for nonvaccinated) and vaccination at birth reduced the incidence.

No association with MMR, pertussis or H. Influenzae type b
Other studies have not found an association between childhood diabetes and measles, mumps and rubella (MMR),7 pertussis,8 or Haemophilus influenzae type b9 vaccines. In the study of MMR vaccine, IgG class mumps antibodies were lower in the case group with diabetes than in the controls, but the significance of this difference in antibody levels was unknown. One study10 observed a protective effect from measles vaccination and an increase in risk of type 1 diabetes with increasing load of infections.

A review by the Cochrane Collaboration Vaccines Field5 concluded that “the papers that explored the relation between vaccination and type 1 diabetes mellitus either did not find evidence of the causal link or found evidence against such a link.” Another recent review3 was in support of this conclusion. Further studies investigating this possible association are currently being conducted.11

References
Gardner SG, Bingley PJ, Sawtell PA, et al. Rising incidence of insulin dependent diabetes in children aged under 5 years in the Oxford region: time trend analysis. BMJ 1997;315:713-7.
Dokheel TM, for the Pittsburgh Diabetes Epidemiology Research Group. An epidemic of childhood diabetes in the United States? Diabetes Care 1993;16:1606-11.
Hiltunen M, Lönnrot M, Hyöty H. Immunisation and type 1 diabetes mellitus. Drug Safety 1999;20:207-12.
Classen DC, Classen JB. The timing of pediatric immunisation and the risk of insulin-dependent diabetes mellitus. Infectious Dis Clin Practice 1997;6:449-54.
Jefferson T, Demicheli V. No evidence that vaccines cause insulin dependent diabetes mellitus. J Epidemiol Community Health 1998;52:674-5.
Parent M-E, Siemiatycki J, Menzies R. Bacille Calmette-Guérin vaccination and incidence of IDDM in Montreal, Canada. Diabetes Care 1997;20:767-72.
Hyöty H, Hiltunen M, Reunanen A, et al. Decline of mumps antibodies in Type 1 (insulin-dependent) diabetic children and a plateau in the rising incidence of Type 1 diabetes after introduction of the mumps-measles-rubella vaccine in Finland. Diabetologia 1993;36:1303-8.
Heijbel H, Chen RT, Dahlquist G. Cumulative incidence of childhood-onset IDDM is unaffected by pertussis immunization. Diabetes Care 1997;20:173-5.
Karvonen M, Cepaitis Z, Tuomiehto J. Association between type 1 diabetes and Haemophilus influenzae type b vaccination: birth cohort study. BMJ 1999;318:1169-72.
Blom L, Nyström L, Dahlquist G. The Swedish childhood diabetes study. Diabetologia 1991;34:176-81.
T Jefferson. Vaccination and its adverse effects: real or perceived. BMJ 1998;317:159-60.”

33 posted on 09/04/2008 9:47:44 AM PDT by count-your-change (you don't have to be brilliant, not being stupid is enough.)
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To: Pharmboy; Incorrigible
Lack of Association between Measles Virus Vaccine and Autism with Enteropathy: A Case-Control Study
34 posted on 09/04/2008 9:57:43 AM PDT by neverdem (I'm praying for a Divine Intervention.)
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To: porter_knorr
Who funded the study?

"Funding: This work was supported by CDC grant U50 CCU522351 to AAP and by National Institutes of Health awards AI57158 (Northeast Biodefense Center-Lipkin), HL083850, and NS47537. Role of Study Sponsors: Members of the funding organization (AAP) and its sponsor (CDC) participated along with experts in virology and neurovirology, autism pathogenesis, and vaccine design and safety; representatives of the autism advocacy community; and study collaborators in an Oversight Committee that reviewed and agreed to all aspects of study design prior to data collection. The final decision to submit for publication was the responsibility of all study collaborators."

The story said: "...the work published in PLoS One, the online journal of the Public Library of Science." All articles from the Public Library of Science are free, open access to the public. I linked the article in comment# 34.

35 posted on 09/04/2008 10:29:28 AM PDT by neverdem (I'm praying for a Divine Intervention.)
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