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New approach will finally kill herpes
The Times of India ^ | 4 Jul 2008, 0254 hrs IST | REUTERS

Posted on 07/04/2008 9:57:35 AM PDT by CarrotAndStick

WASHINGTON: US researchers reported that they may have found a way to flush out herpes viruses from hiding — offering a potential way to cure pesky and painful conditions from cold sores to shingles.

They discovered that a mysterious gene carried by the herpes simplex-1 virus — the one that causes cold sores — allows the virus to lay low in the nerves it infects.

It does so via microRNAs, little pieces of genetic material that regulate the activity of many viruses, the researchers report in the journal Nature.

It may be possible to "wake up" the virus and then kill it with standard antiviral drugs such as acyclovir, said Jennifer Lin Umbach of Duke University in North Carolina, who worked on the study. "We are trying to go into animal trials," Umbach said.

The Duke team is discussing a potential collaboration with Regulus Therapeutics LLC, a joint venture between Alnylam Pharmaceuticals, Inc and Isis Pharmaceuticals, Inc that specializes in microRNAs. Herpes viruses cause permanent infections. They head straight to nerve cells, where they stay latent for the life of an animal or person, often causing periodic outbreaks.

Herpes simplex 1 or HSV-1 causes cold sores, HSV-2 causes genital herpes, while varicella causes chicken pox and returns in middle or old age as herpes zoster to cause shingles.


TOPICS: News/Current Events; Technical
KEYWORDS: health; healthcare; herpes; medical; pathogen; virus
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1 posted on 07/04/2008 9:57:36 AM PDT by CarrotAndStick
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To: CarrotAndStick

Or, stop having sex outside of marriage.


2 posted on 07/04/2008 10:01:22 AM PDT by donna (I am confident that we can create a Kingdom right here on Earth. - Barack Hussein Obama)
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To: CarrotAndStick

Good news for Bill Clinton.


3 posted on 07/04/2008 10:01:36 AM PDT by mkjessup (Jimmy Carter is the Skidmark in the panties of American history.)
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To: donna
Or, stop having sex outside of marriage.

Or learn how to read articles before posting.

4 posted on 07/04/2008 10:02:56 AM PDT by Gondring (I'll give up my right to die when hell freezes over my dead body!)
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To: mkjessup

Bill Clinton and every Media/Hollywood slut will be excited for this news..... but they’ll still have to worry about HIV/AIDS for awhile longer......


5 posted on 07/04/2008 10:06:53 AM PDT by Enchante (OBAMA: "That's not the fraudulent birth certificate I knew!")
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To: donna

I have had shingles before & it is incredibly painful. Shingles has nothing to do with having sex outside of marriage.


6 posted on 07/04/2008 10:08:02 AM PDT by alicewonders (I'm a conservative, and I'm hated by the GOP & the Dems - I must be doing something right!)
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To: Gondring

I hit a nerve, LOL.


7 posted on 07/04/2008 10:08:05 AM PDT by donna ("Don't let the sound of your own wheels drive you crazy.")
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To: alicewonders

Do you really think I said it does?


8 posted on 07/04/2008 10:09:19 AM PDT by donna ("Don't let the sound of your own wheels drive you crazy.")
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To: donna
My mom had shingles. She suffered terribly for almost a decade and is left with horrible scarring.

I had a friend who developed a terrible case of cold sores. They went up her nose, into her sinuses and ended up in her eye.

I also knew a man who's wife brought herpes into the marriage. Should he suffer for the rest of his life because of a lying woman?

Not every ill person did something to deserve it.

9 posted on 07/04/2008 10:10:53 AM PDT by Marie (Why is it that some people believe everything that happens is the will of G-d - except Israel?)
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To: donna

I don’t mean to attack you, but you made a blanket statement. I understand what you are talking about, but a lot of people have the misconception that all herpes is sexually transmitted, and that just isn’t true.


10 posted on 07/04/2008 10:13:02 AM PDT by alicewonders (I'm a conservative, and I'm hated by the GOP & the Dems - I must be doing something right!)
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To: Marie
Should he suffer for the rest of his life because of a lying woman?

No, but he will, won't he - because his wife had sex outside of marriage.

Not every ill person did something to deserve it.

Can we apply some logic here.

I never said anything about shingles because shingles is not caused by sex outside of marriage.

I did not insult you or you mother.

11 posted on 07/04/2008 10:17:19 AM PDT by donna ("Don't let the sound of your own wheels drive you crazy.")
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To: donna
Or, stop having sex outside of marriage.

You've obviously never had shingles... I wouldn't wish it on Michael Moore or Jimmy Carter! 5 years later, I still suffer from the after-effects of it (neuropathy). And I went through the pain of shingles for nearly 6 months.

And you don't get it through sex. If you've had chicken pox, you COULD wind up with shingles. It's the same virus. When chicken pox goes away, the virus goes dormant in the fibers surrounding the nerves in your body. At some point that virus could "wake up," and when it does, congratulations, you've got shingles. Interestingly enough, it's highly contagious, but one can't catch shingles. In the early stages, there are blisters, and the fluid is filled with the virus. And those who haven't had chicken pox can catch it (chicken pox, not shingles) from you.

It's about the most intense pain I've ever experienced, and nothing, short of heavy doses of narcotic pain killers help much.

Mark

12 posted on 07/04/2008 10:17:28 AM PDT by MarkL (Al Gore: The Greenhouse Gasbag! (heard on Bob Brinker's Money Talk))
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To: MarkL

I did not say shingles is caused by sex outside of marriage because it is not.

It is not logical to believe I said anything untrue.


13 posted on 07/04/2008 10:19:06 AM PDT by donna ("Don't let the sound of your own wheels drive you crazy.")
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To: donna
oh, donna.
14 posted on 07/04/2008 10:22:35 AM PDT by Zuben Elgenubi
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To: alicewonders
I don’t mean to attack you, but you made a blanket statement.

Yes you did. I did not make a blanket statement because the article, which I read, clearly states:

"while varicella causes chicken pox and returns in middle or old age as herpes zoster to cause shingles."

It can't be any clearer than that.

15 posted on 07/04/2008 10:23:25 AM PDT by donna ("Don't let the sound of your own wheels drive you crazy.")
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To: donna
Can we apply some logic here.

I never said anything about shingles because shingles is not caused by sex outside of marriage.

I did not insult you or you mother.

The article refers to a possible cure for 3 different types of the herpes virus: Only 1 of the 3 is spread by sexual contact. The other 2 are spread by causal contact. So, in addition to genital herpes, they're talking about finding a possible cure for herpes simplex 1, which causes cold sores, and for chicken pox, which can later return as shingles. If they're able to cure chicken pox, thereby killing the herpes virus that causes it, there will be no outbreaks of shingles.

You're the one that brought up sex, even though only a fraction (1/3) of the diseases mentioned here is spread through sexual contact, and through no fault of their own. So of course you've pissed a bunch of people off. Don't be surprised if you get flamed for this sort of overgeneralized response.

Mark

16 posted on 07/04/2008 10:25:37 AM PDT by MarkL (Al Gore: The Greenhouse Gasbag! (heard on Bob Brinker's Money Talk))
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To: donna
I hit a nerve, LOL.

Yes...FReepers who don't read articles and then make inane irrelevant comments like yours are a pet peeve of mine, because they make people think that FR is full of ignorant fools.

17 posted on 07/04/2008 10:25:57 AM PDT by Gondring (I'll give up my right to die when hell freezes over my dead body!)
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To: Zuben Elgenubi

You know, Ritchie Valens died in that plane crash. Maybe I caused it.


18 posted on 07/04/2008 10:27:18 AM PDT by donna ("Don't let the sound of your own wheels drive you crazy.")
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To: Gondring

You’re a name calling example to the liberals of the world.


19 posted on 07/04/2008 10:28:10 AM PDT by donna ("Don't let the sound of your own wheels drive you crazy.")
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To: donna

You give him the herpes that affected his eyesight in the airplane???


20 posted on 07/04/2008 10:28:42 AM PDT by Zuben Elgenubi
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To: MarkL

Study: 1 in 4 adults in NYC have herpes virus
http://www.freerepublic.com/focus/f-news/2028481/posts


21 posted on 07/04/2008 10:29:01 AM PDT by donna ("Don't let the sound of your own wheels drive you crazy.")
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To: Zuben Elgenubi

Never heard such a thing - you must have inside information.


22 posted on 07/04/2008 10:30:25 AM PDT by donna ("Don't let the sound of your own wheels drive you crazy.")
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To: donna

23 posted on 07/04/2008 10:32:07 AM PDT by Zuben Elgenubi
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To: CarrotAndStick

This article doesn’t say anything new.


24 posted on 07/04/2008 10:33:08 AM PDT by peggybac (Tolerance is the virtue of believing in nothing)
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To: MarkL

“Tell Victor that Ramon-—the fella he met about a week ago?—tell him that Ramon went to the clinic today, and I found out that I have, um, herpes simplex 10, and I think Victor should go check himself out with his physician to make sure everything is fine before things start falling off the man.”


25 posted on 07/04/2008 10:35:20 AM PDT by Dr. Bogus Pachysandra ("Don't touch that thing")
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To: donna
Forget trying to defend yourself. You made an open ended statement that most reasonable people would interpret as " All herpes virus are sexually transmitted, you get what you deserve." Insinuating the whole punishment from God, I'm better than you, etc.

Basically, the comment of an ass.

26 posted on 07/04/2008 10:35:31 AM PDT by muleskinner
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To: Enchante

HPV, too.


27 posted on 07/04/2008 10:40:34 AM PDT by Gondring (I'll give up my right to die when hell freezes over my dead body!)
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To: muleskinner

Donna went to chow down on alfalfa.


28 posted on 07/04/2008 10:43:32 AM PDT by philetus (Keep doing what you always do and you'll keep getting what you always get.)
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To: donna
Okay, so you're not ignorant.

Then you looked like a fool KNOWINGLY, I suppose?

It's not name calling...it's a description of your behavior and your post, which made it seem like you hadn't read the article and were totally ignorant of the topic.

The vast majority of cases of people contracting herpes is non-sexual. Sharing water bottles, kissing, etc., are risky behaviors. Many who contract Type 1 or get chicken pox also contract Type 2, which is usually genital...but there's not a clear line.

I've cared for children who had contracted genital herpes at birth (from their mothers).

I have a friend who contracted genital herpes when she was raped by a creep who had it.

But in fact, the article explicitly stated more than once that the virus in question for this discovery was Herpes-1, not 2. So your comment was ridiculous, as "stop having sex outside of marriage" would not at all provide the relief that this research might lead to.

29 posted on 07/04/2008 10:46:33 AM PDT by Gondring (I'll give up my right to die when hell freezes over my dead body!)
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To: CarrotAndStick

Good. Maybe we won’t have to watch those stupid TV ads anymore of the clueless herpes couples gazing fondly into each other’s eyes.


30 posted on 07/04/2008 10:47:21 AM PDT by Palladin (Obama is a politician, not a statesman.)
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To: muleskinner
"Reasonable people" on FR are supposed to be conservatives. That means responding with their intellect, not their emotions.

Clearly, you value political correctness and if one thing is taken as an insult you can tear the flesh from the bones of any who offend with your insults.

The article spelled out the 3-types. As Rush says, "Word mean things". I shouldn't need to restate the content each time I post. If you have a question, ask.

31 posted on 07/04/2008 10:48:42 AM PDT by donna ("Don't let the sound of your own wheels drive you crazy.")
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To: donna

donna, you ignorant slut.


¨To: CarrotAndStick

Or, stop having sex outside of marriage.

2 posted on Fri 04 Jul 2008 11:01:22 AM MDT by donna¨


That was the entirety of your ´response´ to the article.

You implied that anyone - with any form - of that virus was somehow a ´sinner´, or at least otherwise not worthy of your acceptance or sympathy...

The innocent victim of a straying spouse is as guilty to you as the adulterer?

The same as the child of the innocent wife?

Posts #29 and #30 are worth having you educated on this.


32 posted on 07/04/2008 10:49:09 AM PDT by MtnScout
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To: Zuben Elgenubi

Red x.


33 posted on 07/04/2008 10:51:44 AM PDT by donna ("Don't let the sound of your own wheels drive you crazy.")
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To: alicewonders

I also had shingles - worst pain I ever had - it had me down for a month- Gondring posts without knowing anything about the subject- some people are so stupid.

Oil of Oregano and DMSO plus massive amounts of vitamins was the only thing that really helped. The Doctors gave me very expensive meds that did nothing. If Gondring gets shingles we will not have to suffer such dumb posts.


34 posted on 07/04/2008 10:52:06 AM PDT by EdArt (free to be)
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To: donna

I also had shingles - worst pain I ever had - it had me down for a month- you posted without knowing anything about the subject- some people are so stupid.

Oil of Oregano and DMSO plus massive amounts of vitamins was the only thing that really helped. The Doctors gave me very expensive meds that did nothing. If you were to get shingles you would never make such a dumb post.


35 posted on 07/04/2008 10:54:53 AM PDT by EdArt (free to be)
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To: donna
Study: 1 in 4 adults in NYC have herpes virus

Didn't bother to read that article either, I see. It says in the article, first line, genital herpes.

Oh wait...you read it, but ignored what you read, I suppose. </sarc>

Note that most Americans have HSV-1.

36 posted on 07/04/2008 10:55:56 AM PDT by Gondring (I'll give up my right to die when hell freezes over my dead body!)
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To: MarkL
I had chicken pox when I was 28. A little present from a family at church. My 3 sons also caught it. Fortunately, I was doing all my work from home, so I didn't miss any time from work.

The aftermath for me has been patches that flare up on my little fingers and web of my hands. It happens when the stress at work cranks up. The red, swollen patches sting. Eventually, all the skin dies and sheds. I would welcome a fix for the problem.

37 posted on 07/04/2008 10:56:04 AM PDT by Myrddin
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To: philetus

...with crow.


38 posted on 07/04/2008 10:57:10 AM PDT by Gondring (I'll give up my right to die when hell freezes over my dead body!)
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To: Gondring
The vast majority of cases of people contracting herpes is non-sexual.

That's not true. You are spreading misinformation.

Study: 1 in 4 adults in NYC have herpes virus http://www.freerepublic.com/focus/f-news/2028481/posts

39 posted on 07/04/2008 10:59:01 AM PDT by donna ("Don't let the sound of your own wheels drive you crazy.")
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To: EdArt

HUH?!?!


40 posted on 07/04/2008 10:59:37 AM PDT by Gondring (I'll give up my right to die when hell freezes over my dead body!)
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To: EdArt; donna
First of all, if you're going to mention me, it's common courtesy to ping me. Secondly, what in the heck are you accusing me of? Are you sure you don't mean donna?!?
41 posted on 07/04/2008 11:01:30 AM PDT by Gondring (I'll give up my right to die when hell freezes over my dead body!)
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To: donna

So “1 in 4” is greater than “more than half”?

Wow, your math skills are less than impressive.

Most herpes infections are NOT genital herpes. More than half of Americans have become infected with a herpes virus. Hundreds of millions of children pick up the virus before they’re even adults.


42 posted on 07/04/2008 11:04:14 AM PDT by Gondring (I'll give up my right to die when hell freezes over my dead body!)
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To: donna

“Or, stop having sex outside of marriage.”

So you are against kissing as well?

How about sharing a glass with someone else?

Geez, you are dense. Sex outside of marriage is not the only way to get it.


43 posted on 07/04/2008 11:05:19 AM PDT by webstersII
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To: Gondring

People don’t die from cold sores. About a million people have shingles.


44 posted on 07/04/2008 11:05:58 AM PDT by donna ("Don't let the sound of your own wheels drive you crazy.")
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To: alicewonders

“but a lot of people have the misconception that all herpes is sexually transmitted, and that just isn’t true.”

Don’t confuse some people with the facts!


45 posted on 07/04/2008 11:08:01 AM PDT by A Strict Constructionist (We have become an oligarchy not a Republic.)
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To: Gondring; EdArt

EdArt obviously meant to attack me. Now you want to tear the flesh off his bones, too?

Why don’t you just ask him politely?


46 posted on 07/04/2008 11:08:16 AM PDT by donna ("Don't let the sound of your own wheels drive you crazy.")
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To: CarrotAndStick

Herpes infections of one kind or another are almost universal. They become painful and/or dangerous to a small number of people, for whom an effective treatment will be a great thing.
For now, it seems that the amino acid lysine will suppress most herpes outbreaks. Arginine has the opposite effect, causing herpes to replicate faster.


47 posted on 07/04/2008 11:17:48 AM PDT by devere
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To: donna
Study: 1 in 4 adults in NYC have herpes virus

Well, then this "cure" would be a good thing for them too, wouldn't it? What's the percentage of people in NYC who have had chicken pox?

Just continue your brainless braying attempts at moralizing: There's an old saying, when you're in a hole, the first thing to do is stop digging. You've managed to quickly go from annoying to PITA, and I'm done with anything you've got to "contribute."

Mark

48 posted on 07/04/2008 11:18:38 AM PDT by MarkL (Al Gore: The Greenhouse Gasbag! (heard on Bob Brinker's Money Talk))
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To: Gondring
Most herpes infections are NOT genital herpes. More than half of Americans have become infected with a herpes virus. Hundreds of millions of children pick up the virus before they’re even adults.

I told her that I was "done with her," until I read the incredibly stupid post of her's with the 1/4 of NYC has herpes, and then she goes back to that with the genital herpes... Somebody ask her if she's had chicken pox... If so, then DONNA'S GOT HERPES!!! She doesn't seem to understand that there are a number of different strains of herpes, only one of which is primarily transmitted by sexual contact, though there CAN be a number of ways to transmit the herpes virus which are unexpected: For instance HS1 can be transmitted sexually, and HS2 can be transmitted non-sexually, if the person has had oral sex with someone infected.

Mark

49 posted on 07/04/2008 11:27:53 AM PDT by MarkL (Al Gore: The Greenhouse Gasbag! (heard on Bob Brinker's Money Talk))
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To: MarkL; donna; CarrotAndStick
Everybody run...the homecoming queen has a gun... an agenda...

Myth: If you are in a monogamous relationship and get genital herpes, your partner must be cheating on you.

Fact: You or your partner may have contracted the virus from a sexual partner a long time ago, or, you or your partner may have had genital herpes all along without knowing it. Genital herpes outbreaks can occur with very mild symptoms that go unnoticed. So, the fact is, he or she may not have “cheated on you”.

FAQ

50 posted on 07/04/2008 11:29:22 AM PDT by MtnScout
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